Results 61 to 70 of about 778,717 (328)

A Survey on Optimal Transport for Machine Learning: Theory and Applications

IEEE Access
Optimal Transport (OT) theory has seen increasing attention from the computer science community due to its potency and relevance in modeling and machine learning (ML).
Luiz Manella Pereira, M. Hadi Amini
doaj   +1 more source

Properties of CAD/CAM 3D Printing Dental Materials and Their Clinical Applications in Orthodontics: Where Are We Now?

Applied Sciences, 2022
In the last years, both medicine and dentistry have come across a revolution represented by the introduction of more and more digital technologies for both diagnostic and therapeutic purposes.
Andrea Scribante, Simone Gallo, Maurizio Pascadopoli, Pietro Canzi, Stefania Marconi, Mona A. Montasser, Davide Bressani, Paola Gandini, Maria Francesca Sfondrini   +8 more
doaj   +1 more source

A cellular system to study responses to a collision between the transcription complex and a protein‐bound nick in the DNA template

FEBS Letters, EarlyView.
We present the cellular transcription‐coupled Flp‐nick system allowing the introduction of a Top1‐mimicking cleavage complex (Flpcc) at a Flp recognition target site within a controllable LacZ gene. LacZ transcription leads to the collision of RNA polymerase II (RNAPII) with Flpcc, and this causes RNAPII stalling, ubiquitination, and degradation.
Petra Herring, Morten Roedgaard, Camilla Myrup Holst, Helene Christensen, Birgitta R. Knudsen, Lotte Bjergbaek, Anni Hangaard Andersen   +6 more
wiley   +1 more source

Quantum Genetics, Quantum Automata and Quantum Computation [PDF]

, 2004
The concepts of quantum automata and quantum computation are studied in the context of quantum genetics and genetic networks with nonlinear dynamics. In a previous publication (Baianu,1971a) the formal concept of quantum automaton was introduced and its ...
Baianu, Professor I. C.
core  

Analyzing user-generated online content for drug discovery: Development and use of MedCrawler [PDF]

, 2016
Motivation: Ethnopharmacology, or the scientific validation of traditional medicine, is a respected starting point in drug discovery. Home remedies and traditional use of plants are still widespread, also in Western societies. Instead of perusing ancient
Helfenstein, Andreas, Tammela, Päivi
core   +1 more source

Automation of Knowledge Work in Medicine and Health care: Future and Challenges

International Journal of Body, Mind and Culture, 2017
Increment of computing speed, machine learning and human interface, have extended capabilities of artificial intelligence applications to an important stage. It is predicted that use of artificial intelligence (AI) to automate knowledge-based occupations
Farzan Majidfar
doaj  

STAT3 expression is reduced in cardiac pericytes in HFpEF and its loss reduces cellular adhesion and induces pericyte senescence

FEBS Letters, EarlyView.
Heart failure with preserved ejection fraction (HFpEF) accounts for half of the heart failure cases. It is characterised by microvascular dysfunction, associated with reduced pericyte coverage and diminished STAT3 expression in pericytes. Loss of STAT3 impairs pericyte adhesion, promotes senescence, and activates a pro‐fibrotic gene program.
Leah Rebecca Vanicek, Ariane Fischer, Mariano Ruz Jurado, Anita Tamiato, Tara Procida‐Kowalski, Jochen Wilhelm, Dennis Hecker, Maximilian Merten, Felicitas Escher, Badder Kattih, Valentina Puntmann, David John, Marcel H. Schulz, Eike Nagel, Stefanie Dimmeler, Guillermo Luxán   +15 more
wiley   +1 more source

Indexing large genome collections on a PC

, 2014
Motivation: The availability of thousands of invidual genomes of one species should boost rapid progress in personalized medicine or understanding of the interaction between genotype and phenotype, to name a few applications.
Danek, Agnieszka, Deorowicz, Sebastian, Grabowski, Szymon   +2 more
core   +3 more sources

Ion channel function of polycystin‐2/polycystin‐1 heteromer revealed by structure‐guided mutagenesis

FEBS Letters, EarlyView.
Mutations in polycystin‐1 (PC1) or polycystin‐2 (PC2) cause autosomal‐dominant polycystic kidney disease (ADPKD). We generated a novel gain‐of‐function PC2/PC1 heteromeric ion channel by mutating pore‐blocking residues. Moreover, we demonstrated that PC2 will preferentially assemble with PC1 to form heteromeric complexes when PC1 is co‐expressed ...
Tobias Staudner, Juthamas Khamseekaew, M. Gregor Madej, Linda Geiges, Bardha Azemi, Christine Ziegler, Christoph Korbmacher, Alexandr V. Ilyaskin   +7 more
wiley   +1 more source

AN EXPERT SYSTEM FOR SUPPORTING THE PRODUCTION OF PLEASURE BOATS [PDF]

Management Systems in Production Engineering, 2013
Expert systems can be defined as computer programs, whose main task is to simulate a human expert, usually in a narrow field of expertise. Possible applications of modern information technology are very extensive, ranging from medicine, geology and ...
Tomasz GONCIARZ, Marcin PERZYK
doaj