Results 71 to 80 of about 886,852 (323)

Understanding and measuring mechanical signals in the tumor stroma

FEBS Open Bio, EarlyView.
This review discusses cancer‐associated fibroblast subtypes and their functions, particularly in relation to extracellular matrix production, as well as the development of 3D models to study tumor stroma mechanics in vitro. Several quantitative techniques to measure tissue mechanical properties are also described, to emphasize the diagnostic and ...
Fàtima de la Jara Ortiz, Chiara Cimmino, Maurizio Ventre, Alessandra Cambi   +3 more
wiley   +1 more source

A Detailed Study of SOT-MRAM as an Alternative to DRAM Primary Memory in Multi-Core Environment

IEEE Access
As the current primary memory technology is reaching its limits, it is essential to explore alternative memory technologies to accommodate modern applications and use cases.
H. D. Kallinatha, Sadhana Rai, Basavaraj Talawar   +2 more
doaj   +1 more source

Applying Slicing Technique to Software Architectures [PDF]

Proceedings of the 4th IEEE International Conference on Engineering of Complex Computer Systems, pp.87-98, August 1998, 2001
Software architecture is receiving increasingly attention as a critical design level for software systems. As software architecture design resources (in the form of architectural specifications) are going to be accumulated, the development of techniques and tools to support architectural understanding, testing, reengineering, maintenance, and reuse ...
arxiv  

Evolving Neural Architecture Using One Shot Model [PDF]

arXiv, 2020
Neural Architecture Search (NAS) is emerging as a new research direction which has the potential to replace the hand-crafted neural architectures designed for specific tasks. Previous evolution based architecture search requires high computational resources resulting in high search time. In this work, we propose a novel way of applying a simple genetic
arxiv  

Pharmacological effects of osimertinib on a chicken chorioallantoic membrane xenograft model with the EGFR exon‐19‐deleted advanced NSCLC mutation

FEBS Open Bio, EarlyView.
Osimertinib reduces angiogenesis and PDL1 expression in in ovo tumors, transforming them into ‘cold tumors’ with lower immune activity. Anatomopathological and transcriptomic analyses highlight its therapeutic impact on tumor biology. This study underscores osimertinib's potential to reshape the tumor microenvironment and provides insights into its ...
David Barthélémy, Arnaud Vigneron, Xavier Rousset, Jérome Guitton, Emmanuel Grolleau, Margaux Raffin, Julie Balandier, Gaëlle Lescuyer, Mathilde Bardou, Florence Geiguer, Sébastien Couraud, Claire Bardel, Jean Viallet, Nazim Benzerdjeb, Léa Payen   +14 more
wiley   +1 more source

Differentiable Neural Architecture Transformation for Reproducible Architecture Improvement [PDF]

arXiv, 2020
Recently, Neural Architecture Search (NAS) methods are introduced and show impressive performance on many benchmarks. Among those NAS studies, Neural Architecture Transformer (NAT) aims to improve the given neural architecture to have better performance while maintaining computational costs. However, NAT has limitations about a lack of reproducibility.
arxiv  

Neural Architecture Retrieval [PDF]

arXiv, 2023
With the increasing number of new neural architecture designs and substantial existing neural architectures, it becomes difficult for the researchers to situate their contributions compared with existing neural architectures or establish the connections between their designs and other relevant ones.
arxiv  

Beyond digital twins: the role of foundation models in enhancing the interpretability of multiomics modalities in precision medicine

FEBS Open Bio, EarlyView.
This review highlights how foundation models enhance predictive healthcare by integrating advanced digital twin modeling with multiomics and biomedical data. This approach supports disease management, risk assessment, and personalized medicine, with the goal of optimizing health outcomes through adaptive, interpretable digital simulations, accessible ...
Sakhaa Alsaedi, Xin Gao, Takashi Gojobori   +2 more
wiley   +1 more source

Mapping Hsp104 interactions using cross‐linking mass spectrometry

FEBS Open Bio, EarlyView.
This study examines how cross‐linking mass spectrometry can be utilized to analyze ATP‐induced conformational changes in Hsp104 and its interactions with substrates. We developed an analytical pipeline to distinguish between intra‐ and inter‐subunit contacts within the hexameric homo‐oligomer and discovered contacts between Hsp104 and a selected ...
Kinga Westphal, Karolina Michalska, Andrzej Joachimiak, Lukasz A. Joachimiak   +3 more
wiley   +1 more source

ALCEA: The Architecture Life-Cycle Effect Analysis Method

IEEE Open Journal of Systems Engineering
This article describes the architecture life cycle effect analysis (ALCEA) method, a structured method for evaluating proposed new architectures for software-intensive systems. The method evaluates a proposed architecture by quantifying its effect on the
Jakob Axelsson, Damir Bilic, Daniel Brahneborg, Joakim Froberg, Henrik Gustavsson, Robbert Jongeling, Daniel Sundmark   +6 more
doaj   +1 more source