Results 91 to 100 of about 300,740 (315)

Loss of proton‐sensing TDAG8 increases tumor progression in mouse models of colon cancer

open access: yesMolecular Oncology, EarlyView.
Loss of the pH‐sensing receptor TDAG8 accelerates colorectal cancer progression in mice. Animals lacking TDAG8 expression had increased tumor growth, DNA damage, and recruitment of tumor‐associated immune cells, including macrophages, neutrophils, and monocytes.
Ermanno Malagola   +11 more
wiley   +1 more source

Modes of Interaction in Computational Architecture [PDF]

open access: yes
This thesis is an enquiry into the importance and influence of interaction in architecture, the importance of which is observed through different modes of interaction occurring in various aspects of architectural discourse and practice.
Antic, Dragana Cebzan
core  

Computer System Architecture [PDF]

open access: yes, 2002
Emphasizes the relationship among technology, hardware organization, and programming systems in the evolution of computer architecture. Pipelined, out-of-order, and speculative execution.
Arvind, V.   +3 more
core  

Translating whole‐genome doubling into precision medicine in cancer

open access: yesMolecular Oncology, EarlyView.
Whole‐genome doubling creates a WGD‐positive tumor state characterized by persistent chromosomal instability, karyotypic diversification, and cellular stress. These same biological pressures drive aggressive tumor evolution while exposing therapeutic vulnerabilities, providing a rationale for WGD‐informed precision medicine. Whole‐genome doubling (WGD)
Sejung Lee, Junghyeok Lim, Jinhyuk Bhin
wiley   +1 more source

Melody based tune retrieval over the World Wide Web [PDF]

open access: yes, 1998
In this paper we describe the steps taken to develop a Web-based version of an existing stand-alone, single-user digital library application for melodical searching of a collection of music.
Lloyd A. Smith   +5 more
core  

Single‐cell DNA methylation profiling: Technologies, computation, and applications in precision oncology

open access: yesMolecular Oncology, EarlyView.
Single‐cell DNA methylation (scDNAme) profiling maps epimutational clonal evolution, revealing mechanisms of malignancy and therapeutic resistance across diverse cancer types. By providing a high‐resolution landscape of intratumoral heterogeneity, these technologies empower precise patient stratification, guide the development of enhanced ...
Ik Soo Kim
wiley   +1 more source

Advanced Computer Architecture And Parallel Processing [PDF]

open access: yes, 2005
Computer architects have always strived to increase the performance of theircomputer architectures. High performance may come from fast dense circuitry,packaging technology, and parallelism.
El-Rewini, Hesham, Abd-El-Barr, Mostafa
core  

Digital Electronics and Computer Architecture (CBCS Dec -2019) [PDF]

open access: yes, 2022
DPCS301EST:Digital Electronics and Computer Architecture (CBCS Dec ...
MANUU
core  

CEACAM1 participation in breast cancer progression

open access: yesMolecular Oncology, EarlyView.
In invasive breast cancer (BC), CEACAM1 shifts from an apical to a uniform membranous/cytoplasmic pattern, or is lost, as tumors dedifferentiate, inversely tracking the Ki‐67 proliferative index. In MCF‐7 cells, only CEACAM1‐4L suppresses proliferation, repressing cell cycle and growth factor genes.
Mykola Lyndin   +3 more
wiley   +1 more source

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