Results 111 to 120 of about 300,740 (315)

Single‐molecule DNA flow‐stretch assays for high‐throughput DNA–protein interaction studies

open access: yesFEBS Open Bio, EarlyView.
We describe an optimised single‐molecule DNA flow‐stretch assay that visualises DNA–protein interactions in real time. Linear DNA fragments are tethered to a surface and stretched by buffer flow for fluorescence imaging. Using λ and φX174 DNA, this protocol enhances reproducibility and accessibility, providing a versatile approach for studying diverse ...
Ayush Kumar Ganguli   +8 more
wiley   +1 more source

MB-CNN: Memristive Binary Convolutional Neural Networks for Embedded Mobile Devices

open access: yesJournal of Low Power Electronics and Applications, 2018
Applications of neural networks have gained significant importance in embedded mobile devices and Internet of Things (IoT) nodes. In particular, convolutional neural networks have emerged as one of the most powerful techniques in computer vision, speech ...
Arjun Pal Chowdhury   +2 more
doaj   +1 more source

YIPFα1A expression is regulated by multilayered molecular mechanisms

open access: yesFEBS Open Bio, EarlyView.
YIPFα1A, a five‐pass Golgi protein, is regulated at multiple layers. (1) Rare‐codon enrichment drives translation‐coupled mRNA decay. (2) A proximal 3′‐UTR element stabilizes mRNA. (3) A distal 3′‐UTR element included by alternate poly(A) site usage represses translation, which can be overridden by the proximal 3′‐UTR element.
Tokio Takaji   +2 more
wiley   +1 more source

Molecular dynamics simulations of positively selected codons in FcγRI reveal novel biochemical binding properties

open access: yesFEBS Open Bio, EarlyView.
Evolutionary analysis across 32 placental mammals identified positive selection at residues H148 and W149 in the immune receptor FcγR1. Ancestral reconstruction combined with molecular dynamics simulations reveals how these mutations may influence receptor structure and dynamics, providing insight into the evolution of antibody recognition and immune ...
David A. Young   +7 more
wiley   +1 more source

The Impact of Computer-Aided Design on Representation in Architecture [PDF]

open access: yes, 1990
Representation can be defined as a process of abstraction and communication. Through some symbolic language, characteristics of a real or hypothetical object or experience are conveyed by one person to another.
Y. Kalay, E. Steinfeld
core  

Pharmacological inhibition of the PERK pathway modulates hepatocellular carcinoma growth and immune signaling

open access: yesFEBS Open Bio, EarlyView.
Pharmacological inhibition of PERK in a DEN‐induced mouse model of liver cancer does not reduce tumor burden but alters cellular stress signaling. Despite blocking PERK activity, downstream stress responses, including CHOP expression, remain active, suggesting compensatory mechanisms within the unfolded protein response that may influence tumor ...
Ada Lerma‐Clavero   +5 more
wiley   +1 more source

Computer architecture, networking and parallel processing [PDF]

open access: yes, 2001
The objective is to provide funding for the training of graduate students (M.Eng. and Ph.D.) and research fellows in the area of Computer Architecture, Networking, and Parallel Processing.RGM 4 ...
Hui, Siu Cheung   +8 more
core  

Research and implementation of network transmission situation awareness

open access: yesTongxin xuebao, 2010
The advanced ideas of situation awareness were introduced to network transmission and NTSA(network transmission situation awareness) model was established based on spatial traffic clustering.Around the key technologies of the model,situation factors were
ZHUO Ying, GONG Chun-ye, GONG Zheng-hu
doaj  

Computer Architecture for Industrial Training Evaluation

open access: yesApplied System Innovation
Companies have tried to innovate in their training processes to increase their productivity indicators, reduce equipment maintenance costs, and improve the work environment.
Luz E. Gutiérrez   +5 more
doaj   +1 more source

Early‐life high‐fat diet exposure increases Achilles tendon stiffness and induces transcriptomic alterations

open access: yesFEBS Open Bio, EarlyView.
Early‐life exposure to a high‐fat diet altered intact Achilles tendons in rat offspring, making them thinner, stiffer, and molecularly distinct even without injury. These findings suggest that developmental high‐fat diet exposure may impair tendon quality and increase susceptibility to mechanical overload or tendon injury later in life.
Heyong Yin   +3 more
wiley   +1 more source

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