Results 21 to 30 of about 28,205 (240)

Mass Spectrometry in the Elucidation of the Glycoproteome of Bacterial Pathogens [PDF]

open access: yes, 2010
Presently some three hundred post-translational modifications are known to occur in bacteria in vivo. Many of these modifications play critical roles in the regulation of proteins and control key biological processes.
Graham, Robert L. J., Hess, Sonja
core   +1 more source

Updates in metabolomics tools and resources: 2014-2015 [PDF]

open access: yes, 2016
Data processing and interpretation represent the most challenging and time-consuming steps in high-throughput metabolomic experiments, regardless of the analytical platforms (MS or NMR spectroscopy based) used for data acquisition.
Misra, Biswapriya B.   +1 more
core   +1 more source

Bottom-up construction of ontologies [PDF]

open access: yes, 1998
Presents a particular way of building ontologies that proceeds in a bottom-up fashion. Concepts are defined in a way that mirrors the way their instances are composed out of smaller objects.
Mars, N.J.I., Vet, P.E. van der
core   +3 more sources

Development of a system for computer-assisted structure elucidation of small organic compounds [PDF]

open access: yes, 2023
An unambiguous interpretation and evaluation of nuclear magnetic resonance (NMR) data for the elucidation of chemical structures can become a challenge for organic or natural product chemists.
Wenk, Michael
core  

Logic Structure Determination (LSD) as a Computer Assisted Structure Elucidation (CASE) for Molecular Structure Determination of Cytotoxic Cembranoids from Soft Coral

open access: yesSqualen, 2016
Indonesian tropical soft corals are valuable resources that produce pharmacological cytotoxic cembranoids. However,  the manual structure determination in these compounds requires adequate knowledge of organic chemistry.
Hedi Indra Januar   +3 more
doaj   +1 more source

Differentiating signals to make biological sense – a guide through databases for MS-based non-targeted metabolomics [PDF]

open access: yes, 2017
Metabolite identification is one of the most challenging steps in metabolomics studies and reflects one of the greatest bottlenecks in the entire workflow.
Armitage, Emily Grace   +4 more
core   +1 more source

Building blocks for automated elucidation of metabolites: Machine learning methods for NMR prediction

open access: yesBMC Bioinformatics, 2008
Background Current efforts in Metabolomics, such as the Human Metabolome Project, collect structures of biological metabolites as well as data for their characterisation, such as spectra for identification of substances and measurements of their ...
Neumann Steffen   +3 more
doaj   +1 more source

Sequential application of ligand and structure based modeling approaches to index chemicals for their hH4R antagonism. [PDF]

open access: yesPLoS ONE, 2014
The human histamine H4 receptor (hH4R), a member of the G-protein coupled receptors (GPCR) family, is an increasingly attractive drug target. It plays a key role in many cell pathways and many hH4R ligands are studied for the treatment of several ...
Matteo Pappalardo   +7 more
doaj   +1 more source

Cellular distribution and amount of chromogranin A in bovine endocrine pancreas [PDF]

open access: yes, 1988
We determined the cellular distribution and the amount of chromogranin A in endocrine cells of bovine pancreas using a polyclonal antibody against bovine adrenomedullary chromogranin A. The relative amounts of chromogranin A in the different cells of the
Ehrhart, M.   +3 more
core   +1 more source

Structure analysis of biologically important prokaryotic glycopolymers [PDF]

open access: yes, 2013
Of the many post-translational modifications organisms can undertake, glycosylation is the most prevalent and the most diverse. The research in this thesis focuses on the structural characterisation of glycosylation in two classes of glycopolymer (
Ventura, Valeria Victoria   +1 more
core   +1 more source

Home - About - Disclaimer - Privacy