Results 71 to 80 of about 85,791 (304)

Tau acetylation at K331 has limited impact on tau pathology in vivo

FEBS Letters, EarlyView.
We mapped tau post‐translational modifications in humanized MAPT knock‐in mice and in amyloid‐bearing double knock‐in mice. Acetylation within the repeat domain, particularly around K331, showed modest increases under amyloid pathology. To test functional relevance, we generated MAPTK331Q knock‐in mice.
Shoko Hashimoto, Yukio Matsuba, Mika Takahashi, Takaomi C. Saido   +3 more
wiley   +1 more source

Upper Limb Robot-Assisted Therapy in Cerebral Palsy: A Single-Blind Randomized Controlled Trial

, 2015
Background. Several pilot studies have evoked interest in robot-assisted therapy (RAT) in children with cerebral palsy (CP). Objective. To assess the effectiveness of RAT in children with CP through a single-blind randomized controlled trial.
Dehez, Bruno, Dispa, Delphine, Lejeune, Thierry, Detrembleur, Christine, Renders, Anne, Holvoet, Dominique, Stoquart, Gaëtan, Sapin, Julien, Gilliaux, Maxime   +8 more
core   +1 more source

Toward an AI-assisted Assessment Tool to Support Online Art Therapy Practices: A Pilot Study

, 2022
Artificial intelligence (AI) has been widely used to assist art therapists with artwork assessments by providing objective information. While prior studies showed that AI- assisted tools are feasible to improve drawing analysis in in-person art therapy ...
Jeong, Hyeonhak, Na, Sungmin, Kim, Saeri, Chun, Minki, Jung, Hyunggu, Jun, Joonyoung, Seo, Woosuk, Cho, Woohyun   +7 more
core   +1 more source

Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system

FEBS Letters, EarlyView.
Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley   +1 more source

Self-Administered Cognitive Rehabilitation Using an Electronic Device in Subacute Stroke Patients: A Proof-of-Concept Study on Safety, Feasibility, and Preliminary Efficacy

NeuroSci
Background: Cognitive impairment after stroke often reduces independence and quality of life. Cognitive rehabilitation is therefore essential, and recent research on computer-based interventions has shown promising results.
Cristina Fonte, Alessio Damora, Laura Abbruzzese, Giorgia Rotundo, Alessandro Picelli, Ylenia Gallinaro, Elisa Evangelista, Mauro Mancuso, Nicola Smania, Valentina Varalta   +9 more
doaj   +1 more source

Combining brain-computer interfaces and assistive technologies: state-of-the-art and challenges [PDF]

, 2010
In recent years, new research has brought the field of EEG-based Brain-Computer Interfacing (BCI) out of its infancy and into a phase of relative maturity through many demonstrated prototypes such as brain-controlled wheelchairs, keyboards, and computer ...
R. Rupp, Gernot Mueller-Putz, Cincott, F., Rupp, R., Leeb, R., José del R. Millán, Müller-Putz, Gernot, Mattia, Donatella, Febo Cincotti, Andrea Kubler, D. Mattia, Muller-Putz, G., R. Murray-smith, G. R. Muller Putz, Neuper, C., Klaus R Mueller, del R. Millan, J., R. Murray Smith, M. Tangermann, Millán, José del R., CINCOTTI, FEBO, Giugliemma, Claudio, C. Vidaurre, Robert Leeb, D. Mattia, et al., J. D. R. Millán, Müller, K. R., Giugliemma, C., C. Giugliemma, A. Kubler, Donatella Mattia, F. Cincotti, Neuper, Christa, Müller-Putz, G. R., Kubler, A., Carmen Vidaurre, Mattia, D., C. Neuper, Millán, J. D.R., Tangermann, M., Michael Tangermann, Roderick Murray-Smith, Leeb, Robert, R. Leeb, K. R. Muller, Cincotti, F., Vidaurre, Carmen, Vidaurre, C., G. R. Müller-putz, Muller, K.R., Christa Neuper, Kübler, Andrea, Murray-Smith, R., Rüdiger Rupp, Müller, Klaus Robert, Rupp, Rüdiger, Tangermann, Michael, Murray-Smith, Rod, Claudio Giugliemma   +58 more
core   +1 more source

Valosin‐containing protein counteracts ATP‐driven dissolution of FUS condensates through its ATPase activity in vitro

FEBS Letters, EarlyView.
Biomolecular condensates formed by fused in sarcoma (FUS) are dissolved by high ATP concentrations yet persist in cells. Using a reconstituted system, we demonstrate that valosin‐containing protein (VCP), an AAA+ ATPase, counteracts ATP‐driven dissolution of FUS condensates through its D2 ATPase activity.
Hitomi Kimura, Shin‐ichi Tate, Kyota Yasuda   +2 more
wiley   +1 more source

We can manage depression better with technology [PDF]

, 2014
Provides a summary of the evidence for internet-delivered cognitive behaviour therapy, and looks at the three RACGP Handbook of Non-Drug Intervention (HANDI) recommendations for non-drug treatments for depression and arranged for the developers to ...
Gavin Andrews
core  

Degradation mechanism of the von Willebrand factor A2 domain by nattokinase

FEBS Letters, EarlyView.
Nattokinase, a natto‐derived protease, exhibits potent antithrombotic effects. This study demonstrates that nattokinase directly cleaves the von Willebrand factor (vWF) A2 domain in vitro. Unlike the native regulator ADAMTS13, nattokinase degrades folded vWF independently of shear stress.
Ryuichi Hyakumoto, Masatomo So, Ayako Furukawa, Kenji Sugase   +3 more
wiley   +1 more source

A Prototype Evaluation of a Computer-Assisted Physical Therapy System for Osteoarthritis

, 2008
Purpose: Osteoarthritis is a common locomotor disorder affecting many older people and has become a growing public health problem. Adherence to exercise is a key to the successful recovery of patients but is often a major problem for older adults with ...
Javad Parvizi, Arora, Mohit, Ashish Joshi, Dongsong Zhang, Zhang, Dongsong, Wah, Michael D., Michael D. Wah, Parvizi, Javad, Joshi, Ashish, Mohit Arora   +9 more
core   +1 more source