Results 141 to 150 of about 4,222,894 (339)
Multiple ETS family transcription factors bind mutant p53 via distinct interaction regions
FEBS Letters, EarlyView.Mutant p53 gain‐of‐function is thought to be mediated by interaction with other transcription factors. We identify multiple ETS transcription factors that can bind mutant p53 and found that this interaction can be promoted by a PXXPP motif. ETS proteins that strongly bound mutant p53 were upregulated in ovarian cancer compared to ETS proteins that ...
Stephanie A. Metcalf +6 more
wiley +1 more source
LEA3D: A Computer-Aided Ligand Design for Structure-Based Drug Design
, 2005 Dominique Douguet +3 more
openalex +1 more source
Closure to “Discussions of ‘Design and Analog-Computer Analysis of an Optimum Third-Order Nonlinear Servomechanism’” (1957, Trans. ASME, 79, pp. 523–525) [PDF]
, 1957 H. G. Doll, T. M. Stout
openalex +1 more source
The newfound relationship between extrachromosomal DNAs and excised signal circles
FEBS Letters, EarlyView.Extrachromosomal DNAs (ecDNAs) contribute to the progression of many human cancers. In addition, circular DNA by‐products of V(D)J recombination, excised signal circles (ESCs), have roles in cancer progression but have largely been overlooked. In this Review, we explore the roles of ecDNAs and ESCs in cancer development, and highlight why these ...
Dylan Casey, Zeqian Gao, Joan Boyes
wiley +1 more source
Computer Aided Design for Spray Driers
Iraqi Journal of Chemical and Petroleum Engineering, 2007 The aim of this work is to develop an axi-symmetric two dimensional model based on a coupled simplified computational fluid dynamics (CFD) and Lagrangian method to predict the air flow patterns and drying of particles. Then using this predictive tool to
Adil A. AI-Hemiri, Saad N. Saleh
doaj
Teaching technology awareness: capabilities and thresholds to think about technology
Frontiers in EducationTechnological advances are blurring the boundaries between technical and non-technical disciplines. This shift compels educators to develop teaching methods that equip students with the capabilities necessary to be aware of technological impact and ...
Ole Sneltvedt +2 more
doaj +1 more source
Computer design of microfluidic mixers for protein/RNA folding studies. [PDF]
PLoS One, 2018 Inguva V +3 more
europepmc +1 more source
FEBS Letters, EarlyView.This study reveals how the mitochondrial protein Slm35 is regulated in Saccharomyces cerevisiae. The authors identify stress‐responsive DNA elements and two upstream open reading frames (uORFs) in the 5′ untranslated region of SLM35. One uORF restricts translation, and its mutation increases Slm35 protein levels and mitophagy.
Hernán Romo‐Casanueva +5 more
wiley +1 more source
RNA nanotechnology for computer design and in vivo computation. [PDF]
Philos Trans A Math Phys Eng Sci, 2013 Qiu M +6 more
europepmc +1 more source