Results 71 to 80 of about 2,034,779 (346)
FEBS Letters, EarlyView.The Ile181Asn variant of human UDP‐xylose synthase (hUXS1), associated with a short‐stature genetic syndrome, has previously been reported as inactive. Our findings demonstrate that Ile181Asn‐hUXS1 retains catalytic activity similar to the wild‐type but exhibits reduced stability, a looser oligomeric state, and an increased tendency to precipitate ...
Tuo Li +2 more
wiley +1 more source
Cell wall target fragment discovery using a low‐cost, minimal fragment library
FEBS Letters, EarlyView.LoCoFrag100 is a fragment library made up of 100 different compounds. Similarity between the fragments is minimized and 10 different fragments are mixed into a single cocktail, which is soaked to protein crystals. These crystals are analysed by X‐ray crystallography, revealing the binding modes of the bound fragment ligands.
Kaizhou Yan +5 more
wiley +1 more source
FEBS Letters, EarlyView.We reconstituted Synechocystis glycogen synthesis in vitro from purified enzymes and showed that two GlgA isoenzymes produce glycogen with different architectures: GlgA1 yields denser, highly branched glycogen, whereas GlgA2 synthesizes longer, less‐branched chains.
Kenric Lee +3 more
wiley +1 more source
Structural biology of ferritin nanocages
FEBS Letters, EarlyView.Ferritin is a conserved iron‐storage protein that sequesters iron as a ferric mineral core within a nanocage, protecting cells from oxidative damage and maintaining iron homeostasis. This review discusses ferritin biology, structure, and function, and highlights recent cryo‐EM studies revealing mechanisms of ferritinophagy, cellular iron uptake, and ...
Eloise Mastrangelo, Flavio Di Pisa
wiley +1 more source
FEBS Letters, EarlyView.In this study, we found that human cervical‐derived adipocytes maintain intracellular iron level by regulating the expression of iron transport‐related proteins during adrenergic stimulation. Melanotransferrin is predicted to interact with transferrin receptor 1 based on in silico analysis.
Rahaf Alrifai +9 more
wiley +1 more source
Tau acetylation at K331 has limited impact on tau pathology in vivo
FEBS Letters, EarlyView.We mapped tau post‐translational modifications in humanized MAPT knock‐in mice and in amyloid‐bearing double knock‐in mice. Acetylation within the repeat domain, particularly around K331, showed modest increases under amyloid pathology. To test functional relevance, we generated MAPTK331Q knock‐in mice.
Shoko Hashimoto +3 more
wiley +1 more source
Methods of teaching of using computer experiments in solving mathematical problems
RUDN Journal of Informatization in EducationProblem statement. One of the current trends in mathematical science is the strengthening of the role of the experimental component of mathematical activity under the influence of the development of digital technologies.
Maria V. Shabanova, Maria A. Pavlova
doaj +1 more source
Открытое образование (Москва), 2016 Taking part in the organized project activities students of the technical University create virtual physics laboratories. The article gives an example of the student’s project-computer modeling and visualization one of the most wonderful manifestations ...
Alexander V. Baranov +3 more
doaj +1 more source
Computer vision in microstructural analysis [PDF]
The following is a laboratory experiment designed to be performed by advanced-high school and beginning-college students. It is hoped that this experiment will create an interest in and further understanding of materials science.
Hough, C. L. +2 more
core +1 more source
Boson-Sampling with non-interacting fermions
, 2015 We explore the conditions under which identical particles in unitary linear networks behave as the other species, i.e. bosons as fermions and fermions as bosons. It is found that the Boson-Sampling computer of Aaronson & Arkhipov can be implemented in an
Shchesnovich, Valery S.
core +1 more source