Results 81 to 90 of about 2,034,779 (346)
Calpain small subunit homodimerization is robust and calcium‐independent
FEBS Letters, EarlyView.Calpains dimerize via penta‐EF‐hand (PEF) domains. Using single‐molecule force spectroscopy, we measured the strength and kinetics of PEF–PEF homodimer binding. The interaction is robust, shows a transient conformational step before dissociation, and remains largely insensitive to Ca2+.
Nesha May O. Andoy +4 more
wiley +1 more source
Structural insights into an engineered feruloyl esterase with improved MHET degrading properties
FEBS Letters, EarlyView.A feruloyl esterase was engineered to mimic key features of MHETase, enhancing the degradation of PET oligomers. Structural and computational analysis reveal how a point mutation stabilizes the active site and reshapes the binding cleft, expading substrate scope.
Panagiota Karampa +5 more
wiley +1 more source
Інформаційні технології і засоби навчання, 2010 Theoretical and methodical features of use of modern computer- focused means for teaching of general physics implementing at different levels of studing of general physics in professional and higher school are considered.
Volodymyr P. Serhiienko, Mykola I. Shut
doaj
New Computer Experiment Designs with Area-Interaction Point Processes
MathematicsThis article presents a novel method for constructing computer experiment designs based on the theory of area-interaction point processes. This method is essential for capturing the interactions between different elements within a modeled system ...
Ahmed Ait Ameur +2 more
doaj +1 more source
Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system
FEBS Letters, EarlyView.Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley +1 more source
From Theory to Bench Experiment by Computer-assisted Drug Design
CHIMIA, 2012 Tight integration of computer-assisted molecular design with practical realization by medicinal chemistry will be essential for finding next-generation drugs that are optimized for multiple pharmaceutically relevant properties.
Gisbert Schneider
doaj +1 more source
FEBS Letters, EarlyView.This study reveals a unique active site enriched in methionine residues and demonstrates that these residues play a critical role by stabilizing carbocation intermediates through novel sulfur–cation interactions. Structure‐guided mutagenesis further revealed variants with significantly altered product profiles, enhancing pseudopterosin formation. These
Marion Ringel +13 more
wiley +1 more source
Journal of Asian Architecture and Building Engineering, 2018 In reality, an open space comprises various spatial elements, and people choose a place for sojourn according to the attraction created by the spatial elements.
Mingyeh Hsieh, Yingchu Chen, Wenyen Lee
doaj +1 more source
Perbedaan Waktu Pemberian Jawaban dan Hasil Tes Inteligensi Ditinjau dari Perbedaan Lembar Jawaban
Jurnal Psikologi, 2013 Many intelligence test administered designed as paper and pencil test. But efficiency demand in this time make it administered using computer answer sheet, and testie forced to give answer by blackening answer dots using 2B computer pencil in answer ...
Ridwan Saptoto
doaj +1 more source
Program to produce horizontal stereographic print maps from Nimbus HRIR data [PDF]
, 1972 Computer program is written to display Nimbus high resolution infrared radiometer data in optimum form for experiment usage. Program produces three maps for Nimbus experimental data.
Powell, H. W.
core +1 more source