Results 51 to 60 of about 107,939 (297)

Establishment of a humanized patient‐derived xenograft mouse model of high‐grade serous ovarian cancer for preclinical evaluation of combination immunotherapy

Molecular Oncology, EarlyView.
We have established a humanized orthotopic patient‐derived xenograft (Hu‐oPDX) mouse model of high‐grade serous ovarian cancer (HGSOC) that recapitulates human tumor–immune interactions. Using combined anti‐PD‐L1/anti‐CD73 immunotherapy, we demonstrate the model's improved biological relevance and enhanced translational value for preclinical ...
Luka Tandaric, Line Bjørge, Martine Rott Lode, Cecilie Fredvik Torkildsen, Pia Aehnlich, Rammah Elnour, Daniela Elena Costea, Lars Andreas Akslen, Liv Cecilie Vestrheim Thomsen, Emmet McCormack, Katrin Kleinmanns   +10 more
wiley   +1 more source

An Improved Curvature Circle Algorithm for Orthogonal Projection onto a Planar Algebraic Curve

Mathematics, 2019
Point orthogonal projection onto planar algebraic curve plays an important role in computer graphics, computer aided design, computer aided geometric design and other fields. For the case where the test point p is very far from the planar algebraic
Zhinan Wu, Xiaowu Li
doaj   +1 more source

Differential expression of cancer‐related genes supports prediction of poor response to first‐line treatments in T‐ALL pediatric patients with high minimal residual disease

Molecular Oncology, EarlyView.
In the present work, we have identified a transcriptional signature based on the differential expression of six genes (BCL2&MAST4, HSH2D&LAT2, METRN&PITPNM2) that would facilitate the early detection of T‐cell acute lymphoblastic leukemia (T‐ALL) patients prone to a poor treatment response and could be implemented at diagnosis, along with other risk ...
Antonio Lahera, Laura Vela‐Martín, Pablo Fernández‐Navarro, José Luis López‐Lorenzo, Javier Cornago, Pilar Llamas, Eduardo Pérez‐Gómez, José Luis Marín‐Rubio, Manuel Fresno, Javier Santos, José Fernández‐Piqueras, María Villa‐Morales   +11 more
wiley   +1 more source

O USO DE MODELADORES TRIDIMENSIONAIS PARAMÉTRICOS NA FORMAÇÃO DE COMPETÊNCIAS DE REPRESENTAÇÃO GRÁFICA E RACIOCÍNIO ESPACIAL NO PROCESSO DE PROJETO

Gestão & Tecnologia de Projetos, 2016
This paper reports some reflections on the engineering design graphics (EDG) and product development current paradigms in the context of their teaching and learning processes.
Marcos Martins Borges
doaj   +1 more source

CCDC80 suppresses high‐grade serous ovarian cancer migration via negative regulation of B7‐H3

Molecular Oncology, EarlyView.
PAX8 is a lineage‐specific master regulator of transcription in high‐grade serous ovarian cancer (HGSC) progression. We show for the first time that PAX8 facilitates proliferation and metastasis by repressing the cell autonomous tumor suppressor CCDC80 and inducing B7‐H3 expression.
Aya Saleh, Nitzan Medina‐Itzhaki, Milena Chekov, Eden Gal‐Swisa, Roba Gabesh‐Wahabi, Inbar Savyon, Inna Naroditsky, Hilary A. Kenny, Basem Fares, Lina Korsensky, Einav Girsh, Liron Berger, Ruth Perets   +12 more
wiley   +1 more source

Architecture for Direct Model-to-Part CNC Manufacturing [PDF]

Journal of Systemics, Cybernetics and Informatics, 2006
In the traditional paradigm for Computer Numerical Control (CNC) machining, tool paths are programmed offline from the CNC machine using the Computer-Aided Design (CAD) model of the workpiece.
Gilbert Poon, Paul Gray, Sanjeev Bedi, Daniel Miller   +3 more
doaj  

The interactive-graphic man-computer dialogue in computer-aided circuit design [PDF]

Computer-Aided Design, 1977
The crucial role played by the man-computer dialogue in computer-aided circuit design, and particularly within an interactive graphic medium, is demonstrated by reference to a working circuit design facility implemented on a minicomputer. The detailed nature of this facility and the techniques illustrated are related to the circuit design process and ...
R. Spence, M. Apperley
openaire   +1 more source

E2A selectively regulates TGF‐β–induced apoptosis in KRAS‐mutant non‐small cell lung cancer

Molecular Oncology, EarlyView.
Ability to induce apoptosis by TGF‐β is frequently lost in advanced lung adenocarcinoma despite intact TGF‐β signaling. We identify E2A as a mutant KRAS–dependent mediator of resistance to TGF‐β–induced apoptosis. TGF‐β induces E2A via SMAD3 in mutant KRAS cells, and E2A silencing restores apoptosis and enhances radiation response in cell lines ...
Sergei Chuikov, Shiva Krishna Katkam, Zhefan Wang, Venkateshwar G. Keshamouni   +3 more
wiley   +1 more source

Circulating tumor cell viability during and after radiotherapy mirrors treatment response in cancer patients

Molecular Oncology, EarlyView.
Radiotherapy (RT) response depends on the DNA repair capacity of tumor and host cells. We show that circulating tumor cell (CTC) counts and apoptosis rates before and after RT predict treatment response and outcome, which can be accessed via easily accessible liquid biopsy approaches. Created in BioRender. Wikman, H.
Yvonne Goy, Jana Löptien, Cornelia Coith, Afroditi Nanou, Katharina Hintelmann, Pinnschmidt Hans, Cordula Petersen, Klaus Pantel, Sabine Riethdorf, Kerstin Borgmann, Harriet Wikman   +10 more
wiley   +1 more source

Computer graphics application in the engineering design integration system [PDF]

The computer graphics aspect of the Engineering Design Integration (EDIN) system and its application to design problems were discussed. Three basic types of computer graphics may be used with the EDIN system for the evaluation of aerospace vehicles ...
Abel, R. W., Alford, G. E., Colquitt, W. N., Glatt, C. R., Hirsch, G. N., Stewart, W. A.   +5 more
core   +1 more source