Results 81 to 90 of about 713,888 (318)

Metformin promotes mitochondrial integrity through AMPK‐signaling in Leber's hereditary optic neuropathy

open access: yesFEBS Open Bio, EarlyView.
Metformin mediates mitochondrial quality control in Leber's hereditary optic neuropathy (LHON) fibroblasts carrying mtDNA mutations. At therapeutic levels, metformin activates AMPK signaling to restore mitochondrial dynamics by promoting fusion and restraining fission, while preserving mitochondrial mass, enhancing autophagy/mitophagy and biogenesis ...
Chatnapa Panusatid   +3 more
wiley   +1 more source

Reflective Outcomes in Asynchronous Computer Mediated Communication: A Case Study using a Comparative Method [PDF]

open access: yes, 2011
In an era of constant educational reforms, many acknowledge teachers’ professional development as the keystone to educational improvement. The issue of whether teachers’ development is adequate has been crucial in all times, especially now that ...
PAVLIDOU, AIKATERINI
core  

The nature of virtual communities [PDF]

open access: yes, 2006
The impressive development of electronic communication techniques has given rise to virtual\ud communities. The nature of these computer-mediated communities has been the subject of much recent\ud debate.
Memmi, Daniel
core   +1 more source

Untangling a Web of Lies: Exploring Automated Detection of Deception in Computer-Mediated Communication

open access: yesJournal of Management Information Systems, 2016
Safeguarding organizations against opportunism and severe deception in computer-mediated communication (CMC) presents a major challenge to chief information officers and information technology managers.
S. Ludwig   +3 more
semanticscholar   +1 more source

FGFR Like1 drives esophageal cancer progression via EMT, PI3K/Akt, and notch signalling: insights from clinical data and next‐generation sequencing analysis

open access: yesFEBS Open Bio, EarlyView.
Clinical analysis reveals significant dysregulation of FGFRL1 in esophageal cancer (EC) patients. RNAi‐coupled next‐generation sequencing (NGS) and in vitro study reveal FGFRL1‐mediated EC progression via EMT, PI3K/Akt, and Notch pathways. Functional assays confirm its role in tumor growth, migration, and invasion.
Aprajita Srivastava   +3 more
wiley   +1 more source

INTERCULTURAL COMMUNICATION PATTERNS AND LANGUAGE USE IN COMPUTER MEDIATED-COMMUNICATION [PDF]

open access: yesStudii si Cercetari Filologice: Seria Limbi Straine Aplicate, 2012
This paper aims at analyzing the degree to which intercultural communication patterns are embedded in computer-mediated communication. Drawing on Hall’s and Hofstede’s intercultural communication dimensions, this study evaluates empirically high-versus-
Adriana Teodorescu
doaj  

Theory of Robot Communication: II. Befriending a Robot over Time

open access: yes, 2018
In building on theories of Computer-Mediated Communication (CMC), Human-Robot Interaction, and Media Psychology (i.e. Theory of Affective Bonding), the current paper proposes an explanation of how over time, people experience the mediated or simulated ...
Hoorn, Johan F.
core  

The role of lipid metabolism in neuronal senescence

open access: yesFEBS Open Bio, EarlyView.
Disrupted lipid metabolism, through alterations in lipid species or lipid droplet accumulation, can drive neuronal senescence. However, lipid dyshomeostasis can also occur alongside neuronal senescence, further amplifying tissue damage. Delineating how lipid‐induced senescence emerges in neurons and glial cells, and how it contributes to ageing and ...
Dikaia Tsagkari   +2 more
wiley   +1 more source

Learners’ use of communication strategies in text-based and video-based synchronous computer-mediated communication environments: opportunities for language learning

open access: yes, 2016
This study investigates the different learning opportunities enabled by text-based and video-based synchronous computer-mediated communication (SCMC) from an interactionist perspective.
Yu-Wan Hung, S. Higgins
semanticscholar   +1 more source

Microglial dynamics and ferroptosis induction in human iPSC‐derived neuron–astrocyte–microglia tri‐cultures

open access: yesFEBS Open Bio, EarlyView.
A tri‐culture of iPSC‐derived neurons, astrocytes, and microglia treated with ferroptosis inducers as an Induced ferroptosis model was characterized by scRNA‐seq, cell survival, and cytokine release assays. This analysis revealed diverse microglial transcriptomic changes, indicating that the system captures key aspects of the complex cellular ...
Hongmei Lisa Li   +6 more
wiley   +1 more source

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