Results 141 to 150 of about 1,888,285 (303)

Multiscale Computer Modeling of Spreading Depolarization in Brain Slices. [PDF]

eNeuro, 2022
Kelley C, Newton AJH, Hrabetova S, McDougal RA, Lytton WW.   +4 more
europepmc   +1 more source

SecGPSR: A Secure GPSR Protocol for FANET Against Sybil and Gray Hole Attacks

IEEE Access
In recent years, drones have become increasingly prevalent in a wide range of applications, performing complex and critical tasks. To accomplish these tasks, drones cooperate by forming a Flying Ad-Hoc Network (FANET) using specific routing protocols for
Mauro Tropea, Mattia Giovanni Spina, Abderrahmane Lakas, Panagiotis Sarigiannidis, Floriano de Rango   +4 more
doaj   +1 more source

The ubiquitin ligase RNF115 is required for the clearance of damaged lysosomes

FEBS Letters, EarlyView.
Upon lysosomal rupture, an E3 ubiquitin ligase RNF115 translocates from the cytosol to the damaged lysosomal membrane. Moreover, RNF115 depletion impairs the clearance of damaged lysosomes, identifying it as a key regulator of lysosomal quality control.
Sae Nakanaga, Toshiki Takahashi, Akiko Kuma, Hiroyuki Kawahara   +3 more
wiley   +1 more source

Insights into the Pharmacological Effects of Flavonoids: The Systematic Review of Computer Modeling. [PDF]

Int J Mol Sci, 2022
Taldaev A, Terekhov R, Nikitin I, Zhevlakova A, Selivanova I.   +4 more
europepmc   +1 more source

An Agent-Based Model of Behavior in “Beauty Contest” Games [PDF]

Recently, computer simulation, particularly agent-based modeling, has grown in popularity as a method to uncover macro patterns and developments that emerge from simple micro behavior. The present paper combines both techniques by using protocol analysis
Mark W. Nichols, Michael J. Radzicki
core  

pH‐mediated activation of the lysosomal arginine sensor SLC38A9

FEBS Letters, EarlyView.
Cells monitor nutrient levels via the lysosomal transporter SLC38A9 to activate the mechanistic target of rapamycin complex 1 (mTORC1). This study reveals that SLC38A9 function is regulated by pH. We identified histidine 544 as a critical pH sensor that undergoes conformational changes to control amino acid efflux from lysosomes; therefore, it ...
Xuelang Mu, Ampon Sae Her, Tamir Gonen
wiley   +1 more source

How intramyocardial fat can alter the electric field distribution during Pulsed Field Ablation (PFA): Qualitative findings from computer modeling. [PDF]

PLoS One, 2023
Pérez JJ, González-Suárez A.
europepmc   +1 more source

The neural crest‐associated gene ERRFI1 is involved in melanoma progression and resistance toward targeted therapy

Molecular Oncology, EarlyView.
ERRFI1, a neural crest (NC)‐associated gene, was upregulated in melanoma and negatively correlated with the expression of melanocytic differentiation markers and the susceptibility of melanoma cells toward BRAF inhibitors (BRAFi). Knocking down ERRFI1 significantly increased the sensitivity of melanoma cells to BRAFi.
Nina Wang, Qian Sun, Daniel Novak, Lei Zhu, Juliane Poelchen, Tamara Steinfass, Yiman Wang, Viktor Umansky, Jochen Utikal   +8 more
wiley   +1 more source

Computer modeling reveals modalities to actuate mutable, active matter. [PDF]

Nat Commun, 2022
Laskar A, Manna RK, Shklyaev OE, Balazs AC.   +3 more
europepmc   +1 more source

In vitro models of cancer‐associated fibroblast heterogeneity uncover subtype‐specific effects of CRISPR perturbations

Molecular Oncology, EarlyView.
Development of therapies targeting cancer‐associated fibroblasts (CAFs) necessitates preclinical model systems that faithfully represent CAF–tumor biology. We established an in vitro coculture system of patient‐derived pancreatic CAFs and tumor cell lines and demonstrated its recapitulation of primary CAF–tumor biology with single‐cell transcriptomics ...
Elysia Saputra, Shamsudheen Karuthedath Vellarikkal, Lixia Li, Hong Sun, Khoa Nguyen, Amber Montano, Suchitra Natarajan, Federica Piccioni, Alex Michael Tamburino, Xin Yu, Aleksandra Katarzyna Olow   +10 more
wiley   +1 more source