Results 141 to 150 of about 5,472,505 (257)

Measurement of selection coefficients from genomic samples of adapting populations by computer modeling. [PDF]

STAR Protoc, 2023
Likhachev IV, Rouzine IM.
europepmc   +1 more source

Investigating transcription factor dynamics in health and disease using FRAP

FEBS Letters, EarlyView.
FRAP analysis of GFP‐tagged transcription factors reveals how molecular mobility and target engagement change in response to drug treatment. By combining live‐cell imaging, quantitative model fitting, and statistical analysis, this approach uncovers transcription factor dynamics linked to disease mechanisms, providing a powerful framework for ...
Kannan Govindaraj, Carolina Vazquez Garzon, Jose Joaquin Velasco, Janine N. Post   +3 more
wiley   +1 more source

SecGPSR: A Secure GPSR Protocol for FANET Against Sybil and Gray Hole Attacks

IEEE Access
In recent years, drones have become increasingly prevalent in a wide range of applications, performing complex and critical tasks. To accomplish these tasks, drones cooperate by forming a Flying Ad-Hoc Network (FANET) using specific routing protocols for
Mauro Tropea, Mattia Giovanni Spina, Abderrahmane Lakas, Panagiotis Sarigiannidis, Floriano de Rango   +4 more
doaj   +1 more source

Multiscale Computer Modeling of Spreading Depolarization in Brain Slices. [PDF]

eNeuro, 2022
Kelley C, Newton AJH, Hrabetova S, McDougal RA, Lytton WW.   +4 more
europepmc   +1 more source

Modeling and Simulating Computer Networks Using Formalized Data Flow Diagrams [PDF]

, 1996
Formalized Data Flow Diagrams (FDFD's) provide simple and natural abstractions for specifying network behavior. We have augmented FDFD's by providing (i) a notion of asynchronous timing of events, (ii) a convenient mechanism for describing "node classes"
Haverdink, Michael, Mikler, Armin, Baker, Albert   +2 more
core  

Conserved binding mode but diverse interfaces of MreC‐PBP2 interactions

FEBS Letters, EarlyView.
The crystal structure of abMreC reveals a conserved two β‐barrel architecture and provides structural insights into its role within the bacterial elongasome. The abMreC–abPBP2 complex model identifies the molecular basis of MreC‐mediated PBP2 recognition, contributing to the regulation of peptidoglycan synthesis.
Hyunseok Jang, Hyo Been Jin, Chang Min Kim, So Yeon Lee, Hyun Ho Park   +4 more
wiley   +1 more source

Camera shooting location recommendations for landmarks in geo-space

, 2013
10.1109/MASCOTS.2013.25Proceedings - IEEE Computer Society's Annual International Symposium on Modeling, Analysis, and Simulation of Computer and Telecommunications Systems, MASCOTS172 ...
Roger Zimmermann, Zimmermann, R., Ying Zhang, Zhang, Y.   +3 more
core   +1 more source

Microbiome‐blood–brain barrier interactions in aging — mechanisms and therapeutic potential

FEBS Letters, EarlyView.
Aging reshapes the gut microbiome (↓SCFA‐producing commensals; ↑pro‐inflammatory outputs), shifting circulating metabolites (↓SCFAs; ↑LPS, ↑TMAO, ↑PAA) that act at the BBB to increase nonspecific transcytosis, alter transport, and promote astrocyte reactivity, heightening brain vulnerability.
Daniel Cuervo‐Zanatta, Hari Baskar Balasubramanian, Amir Pasokh, Marietta Zille   +3 more
wiley   +1 more source

Computer modeling reveals modalities to actuate mutable, active matter. [PDF]

Nat Commun, 2022
Laskar A, Manna RK, Shklyaev OE, Balazs AC.   +3 more
europepmc   +1 more source

Engineering peptides into antibodies—opportunities and strategies for therapeutic innovation

FEBS Letters, EarlyView.
Peptides and antibodies occupy complementary therapeutic niches. Peptides recognize difficult targets in a compact format, while antibodies add specificity, long half‐life, and effector functions. This review examines strategies that merge both modalities—peptide grafting into loops, terminal and Fc fusions, and bioconjugation—highlighting how ...
Jinling Wang, Ruslana Romaniuk, Hristo L. Svilenov   +2 more
wiley   +1 more source