Structural insights and therapeutic targets in Acinetobacter baumannii capsule biosynthesis
FEBS Letters, EarlyView.Hypervirulent KL49 A. baumannii's capsular polysaccharide contains the nonulosonic acid 8‐epi‐Leg5,7Ac2, synthesized by epimerization via ElaA, ElaB, and ElaC. Crystal structures of ElaA, ElaB, and ElaC reveal their role in CMP‐Leg5,7Ac2 synthesis and regioselective C8 epimerization.
Woo Cheol Lee +7 more
wiley +1 more source
Computer modeling reveals modalities to actuate mutable, active matter. [PDF]
Nat Commun, 2022 Laskar A +3 more
europepmc +1 more source
Cell Cycle Modeling for Budding Yeast with Stochastic Simulation Algorithms
, 2008 For biochemical systems, where some chemical species are represented by small numbers of molecules, discrete and stochastic approaches are more appropriate than continuous and deterministic approaches. The continuous deterministic approach using ordinary
Ahn, Tae-Hyuk +4 more
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Modeling and Simulation of Electrochemical DNA Biosensors in CMOS Technology [PDF]
, 2007 Early detection of pathogens in food and water samples is essential in containing and preventing the spread of various diseases, such as campylobacter jejuni or E-coli.
Shinwari, M
core
FEBS Letters, EarlyView.Inositol pyrophosphates are energy‐rich signaling molecules that perform critical functions in cells. Three different families of phosphatases hydrolyze the β phosphate of the inositol pyrophosphate molecules: two have narrow specificities and one is promiscuous.
Ronda J. Rolfes
wiley +1 more source
How intramyocardial fat can alter the electric field distribution during Pulsed Field Ablation (PFA): Qualitative findings from computer modeling. [PDF]
PLoS One, 2023 Pérez JJ, González-Suárez A.
europepmc +1 more source
Design and analysis strategies for robust microbiome ageing research
FEBS Letters, EarlyView.The gut microbiome changes with age and associates with age‐related morbidity and mortality, establishing it as a potential biomarker and intervention target for ageing. Realising this potential requires methodological rigour, yet distinguishing biological signals from methodological artefacts remains challenging across cohorts. This review provides an
Mark Olenik +5 more
wiley +1 more source
Humeral Head Reconstruction With Osteochondral Allograft: Bone Plug Optimization for Hill-Sachs Lesions Using CT-Based Computer Modeling Analysis. [PDF]
Orthop J Sports Med, 2023 Ganokroj P +7 more
europepmc +1 more source
MOANA: Modeling and Analyzing I/O Variability in Parallel System Experimental Design
, 2018 Exponential increases in complexity and scale make variability a growing threat to sustaining HPC performance at exascale. Performance variability in HPC I/O is common, acute, and formidable. We take the first step towards comprehensively studying linear
Xu, Li +9 more
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