Results 201 to 210 of about 414,610 (315)

Pennes' bioheat equation vs. porous media approach in computer modeling of radiofrequency tumor ablation. [PDF]

Sci Rep, 2021
Tucci C, Trujillo M, Berjano E, Iasiello M, Andreozzi A, Vanoli GP.   +5 more
europepmc   +1 more source

IMPDH inhibition enhances cytarabine efficacy in SAMHD1‐expressing leukaemia cells via guanine nucleotide depletion

Molecular Oncology, EarlyView.
Cytarabine is a key therapy for acute myeloid leukaemia (AML), but its efficacy is limited by the dNTPase SAMHD1, which hydrolyses its active metabolite. Screening nucleotide biosynthesis inhibitors revealed that IMPDH inhibitors selectively sensitise SAMHD1‐proficient AML cells to cytarabine.
Miriam Yagüe‐Capilla, Christopher Dirks, Caroline Eiden, Sonja K. Fesenmayer, Femke M. Hormann, Yolande Klootsema, Ingrid Lilienthal, Si Min Zhang, Nikolas Herold, Sean G. Rudd   +9 more
wiley   +1 more source

Using Computer Modeling and Experimental Methods to Screen for Aptamers That Bind to the VV-GMCSF-LACT Virus. [PDF]

Molecules
Dymova M, Vasileva N, Malysheva D, Ageenko A, Shchugoreva I, Artyushenko P, Tomilin F, Kichkailo AS, Kuligina E, Richter V.   +9 more
europepmc   +1 more source

Guidebook on molecular modeling in drug design /

, 1996
Specially designed computer software is revolutionizing procedures for structured or rational drug design and discovery. The Guidebook on Molecular Modeling in Drug Design serves as a manual for the analysis ofmolecular structure and the correlation of ...
Cohen, N. Claude.
core  

Keratin 19 as a prognostic marker and contributing factor of metastasis and chemoresistance in high‐grade serous ovarian cancer

Molecular Oncology, EarlyView.
Keratin 19 (KRT19) is overexpressed in high‐grade serous ovarian cancer with high levels of Kallikrein‐related peptidases (KLK) 4–7 and is associated with poor survival. In vivo analyses demonstrate that elevated KRT19 increases peritoneal tumour burden.
Sophia Bielesch, Isabel Vogel, Sina Nokodian, Johanna Moeller, Antonia Blechschmidt, Vicky Hecht, Vanessa Kuentzel, Katharina Thiedig, Melissa Schwab, Oliver Schilling, Holger Bronger, Marion Kiechle, Viktor Magdolen, Tobias Dreyer   +13 more
wiley   +1 more source

Ablation catheter-induced mechanical deformation in myocardium: computer modeling and ex vivo experiments. [PDF]

Med Biol Eng Comput
Ijima Y, Masnok K, Perez JJ, González-Suárez A, Berjano E, Watanabe N.   +5 more
europepmc   +1 more source

Computer modeling of diffusion in biological tissues

, 2013
Molecular-level computer simulations of restricted water diffusion can be used to develop models for relating diffusion tensor imaging measurements of anisotropic tissue to microstructural tissue characteristics.
Powell, Sean K., Momot, Konstantin I.
core  

Somatic mutational landscape in von Hippel–Lindau familial hemangioblastoma

Molecular Oncology, EarlyView.
The causes of central nervous system (CNS) hemangioblastoma in Von Hippel–Lindau (vHL) disease are unclear. We used Whole Exome Sequencing (WES) on familial hemangioblastoma to investigate events that underlie tumor development. Our findings suggest that VHL loss creates a permissive environment for tumor formation, while additional alterations ...
Maja Dembic, Anne Nørremølle, Lilian Bomme Ousager, Lars van Brakel Andersen, Marie Louise Mølgaard Binderup, Mads Thomassen   +5 more
wiley   +1 more source

Identification of Potent siRNA Delivery Peptides Using Computer Modeling. [PDF]

Adv Sci (Weinh)
Men K, Liu M, Zhang X, Yang Y, Zhang R, Wang Y, Hu D, Zhou B, Yang L.   +8 more
europepmc   +1 more source

Effects of control temperature, ablation time, and background tissue in radiofrequency ablation of osteoid osteoma: A computer modeling study. [PDF]

Int J Numer Method Biomed Eng, 2021
Rivas R, Hijlkema RB, Cornelissen LJ, Kwee TC, Jutte PC, van Ooijen PMA.   +5 more
europepmc   +1 more source