Results 201 to 210 of about 1,888,285 (303)

Computer modeling and validation testing for glenoid component rotation and optimal glenoid screw angles for reverse shoulder arthroplasty in an Asian population. [PDF]

Int Orthop
Cheng SSM, Yung CS, Wong SH, Yip CCH, Khoo IJR, Wong TWK, Fang C.   +6 more
europepmc   +1 more source

Small Random Angular Variations in Pelvic Tilt and Lower Extremity Can Cause Error in Static Image-based Preoperative Hip Arthroplasty Planning: A Computer Modeling Study. [PDF]

Clin Orthop Relat Res, 2022
Eslam Pour A, Lazennec JY, Patel KP, Anjaria MP, Beaulé PE, Schwarzkopf R.   +5 more
europepmc   +1 more source

Genetic attenuation of ALDH1A1 increases metastatic potential and aggressiveness in colorectal cancer

Molecular Oncology, EarlyView.
Aldehyde dehydrogenase 1A1 (ALDH1A1) is a cancer stem cell marker in several malignancies. We established a novel epithelial cell line from rectal adenocarcinoma with unique overexpression of this enzyme. Genetic attenuation of ALDH1A1 led to increased invasive capacity and metastatic potential, the inhibition of proliferation activity, and ultimately ...
Martina Poturnajova, Zuzana Kozovska, Ondrej Pos, Kristina Pavlov, Sachin Gulati, Peter Makovicky, Kristina Jakic, Monika Burikova, Eva Sedlackova, Barbora Svitkova, Silvia Tyciakova, Vojtech Bystry, Nicolas Blavet, Boris Tichy, Matej Hrnciar, Jaroslav Budis, Miroslav Tomas, Peter Dubovan, Georgina Kolnikova, Veronika Repaska, Nikoleta Mojzesova, Eva Zomborska, Daniel Pindak, Michal Mego, Tomas Szemes, Miroslava Matuskova   +25 more
wiley   +1 more source

Dimethyl fumarate combined with cisplatin at subcytotoxic doses sensitizes cervical cancer toward ferroptosis and apoptosis through GSH restriction and p53 (re)activation

Molecular Oncology, EarlyView.
Dimethyl fumarate (DMF) reduces growth of HPV‐positive cervical cancer spheroids and induces ferroptosis in cervical cancer cells via blocking SLC7A11/Glutathione (GSH) axis. Combination of subcytotoxic doses of DMF and cisplatin (CDDP) further suppresses spheroid growth and drives cell death in 2D culture models.
Carolina Punziano, Giuseppina Minopoli, Simona Romano, Laura Marrone, Katia Aquilano, Maria Lina Tornesello, Raffaella Faraonio   +6 more
wiley   +1 more source

Promoter recognition specificity of Corynebacterium glutamicum stress response sigma factors σ^D and σ^H deciphered using computer modeling and point mutagenesis. [PDF]

J Comput Aided Mol Des
Blumenstein J, Dostálová H, Rucká L, Štěpánek V, Busche T, Kalinowski J, Pátek M, Barvík I.   +7 more
europepmc   +1 more source

CORR Insights®: Small Random Angular Variations in Pelvic Tilt and Lower Extremity Can Cause Error In Static Image-based Preoperative Hip Arthroplasty Planning: A Computer Modeling Study. [PDF]

Clin Orthop Relat Res, 2022
Giori NJ.
europepmc   +1 more source

Targeted modulation of IGFL2‐AS1 reveals its translational potential in cervical adenocarcinoma

Molecular Oncology, EarlyView.
Cervical adenocarcinoma patients face worse outcomes than squamous cell carcinoma counterparts despite similar treatment. The identification of IGFL2‐AS1's differential expression provides a molecular basis for distinguishing these histotypes, paving the way for personalized therapies and improved survival in vulnerable populations globally.
Ricardo Cesar Cintra, Lucca Paolo Hsu Helmich, Daniel Rodrigues de Bastos, Laura Sichero, Patrícia Savio de Araujo‐Souza, Fabio Passetti, Luisa Lina Villa   +6 more
wiley   +1 more source

Optimizing the releasing strategy used for the biological control of the sugarcane borer Diatraea saccharalis by Trichogramma galloi with computer modeling and simulation. [PDF]

Sci Rep
Gomes Garcia A, Wajnberg E, Parra JRP.
europepmc   +1 more source

Computer modeling of whole-cell voltage-clamp analyses to delineate guidelines for good practice of manual and automated patch-clamp. [PDF]

Sci Rep, 2021
Montnach J, Lorenzini M, Lesage A, Simon I, Nicolas S, Moreau E, Marionneau C, Baró I, De Waard M, Loussouarn G.   +9 more
europepmc   +1 more source

Network divergence analysis identifies adaptive gene modules and two orthogonal vulnerability axes in pancreatic cancer

Molecular Oncology, EarlyView.
Tumors contain diverse cellular states whose behavior is shaped by context‐dependent gene coordination. By comparing gene–gene relationships across biological contexts, we identify adaptive transcriptional modules that reorganize into distinct vulnerability axes.
Brian Nelson, Lyanne Delgado‐Coka, Natalia Marchenko, Luisa F. Escobar‐Hoyos, Kenneth R. Shroyer, Alisa Yurovsky, Trey Ideker, Gábor Balázsi, Thomas MacCarthy, Scott Powers   +9 more
wiley   +1 more source