Results 181 to 190 of about 414,610 (315)

Large-scale analysis and computer modeling reveal hidden regularities behind variability of cell division patterns in Arabidopsis thaliana embryogenesis. [PDF]

Elife, 2022
Laruelle E, Belcram K, Trubuil A, Palauqui JC, Andrey P.   +4 more
europepmc   +1 more source

Network divergence analysis identifies adaptive gene modules and two orthogonal vulnerability axes in pancreatic cancer

Molecular Oncology, EarlyView.
Tumors contain diverse cellular states whose behavior is shaped by context‐dependent gene coordination. By comparing gene–gene relationships across biological contexts, we identify adaptive transcriptional modules that reorganize into distinct vulnerability axes.
Brian Nelson, Lyanne Delgado‐Coka, Natalia Marchenko, Luisa F. Escobar‐Hoyos, Kenneth R. Shroyer, Alisa Yurovsky, Trey Ideker, Gábor Balázsi, Thomas MacCarthy, Scott Powers   +9 more
wiley   +1 more source

Evaluating the Effect of Random Multi-Donor Pooling on the Nutritional Variability in Donor Human Milk Using Computer Modeling. [PDF]

Matern Child Nutr
Smith RM, Richter S, Iwayemi EF, Mansen K, Israel-Ballard K, Hampel D, Shahab-Ferdows S, Allen LH, Bode L, Perrin MT.   +9 more
europepmc   +1 more source

A Simple Method to Improve Detection of Femoral Nail Abutment in the Distal Femur: A Computer Modeling Study. [PDF]

Clin Orthop Relat Res, 2022
Sarai H, Schmutz B, Schuetz M.
europepmc   +1 more source

Visualizing and Modeling Categorical Time Series Data

, 1995
Categorical time series data can not be effectively visualized and modeled using methods developed for ordinary data. The arbitrary mapping of categorical data to ordinal values can have a number of undesirable consequences.
Ribler, Randy, Mathur, Anup, Abrams, Marc   +2 more
core  

COMP–PMEPA1 axis promotes epithelial‐to‐mesenchymal transition in breast cancer cells

Molecular Oncology, EarlyView.
This study reveals that cartilage oligomeric matrix protein (COMP) promotes epithelial‐to‐mesenchymal transition (EMT) in breast cancer. We identify PMEPA1 (protein TMEPAI) as a novel COMP‐binding partner that mediates EMT via binding to the TSP domains of COMP, establishing the COMP–PMEPA1 axis as a key EMT driver in breast cancer.
Konstantinos S. Papadakos, Gilar Gorji‐bahri, Lejla Gradjan, Julia Zajac, Kacper Gil, Yvonne Thokozile Nduku, Anna M. Blom   +6 more
wiley   +1 more source

Using computer modeling to find new LRRK2 inhibitors for parkinson's disease. [PDF]

Sci Rep
García MC, Cuesta SA, Mora JR, Paz JL, Marrero-Ponce Y, Alexis F, Márquez EA.   +6 more
europepmc   +1 more source

Why Is Only Type 1 Electrocardiogram Diagnostic of Brugada Syndrome? Mechanistic Insights From Computer Modeling. [PDF]

Circ Arrhythm Electrophysiol, 2022
Zhang Z, Chen PS, Weiss JN, Qu Z.
europepmc   +1 more source

Pre‐analytical optimization of cell‐free DNA and extracellular vesicle‐derived DNA for mutation detection in liquid biopsies

Molecular Oncology, EarlyView.
Pre‐analytical handling critically determines liquid biopsy performance. This study defines practical best‐practice conditions for cell‐free DNA (cfDNA) and extracellular vesicle–derived DNA (evDNA), showing how processing time, storage conditions, tube type, and plasma input volume affect DNA integrity and mutation detection.
Jonas Dohmen, Lucrezia De Santis, Bret M. Stephens, Vincent Bernard, Jörg C. Kalff, Lara Braun, Phillipp Leyendecker, Johannes Röttgen, Daniel Weissinger, Anirban Maitra, Paola A. Guerrero, Alexander Semaan   +11 more
wiley   +1 more source

Computer modeling of spatial dynamics and primary genetic divergence for a population system in a ring areal. [PDF]

Vavilovskii Zhurnal Genet Selektsii
Kulakov MP, Zhdanova OL, Frisman EY.
europepmc   +1 more source