Results 181 to 190 of about 5,472,505 (257)

RNA‐related functions of BRCA2 in transcription, replication, and genome stability

open access: yesFEBS Letters, EarlyView.
Beyond its role in homologous recombination, BRCA2 regulates R‐loop homeostasis, DNA–RNA hybrid resolution, RNA polymerase II dynamics, and transcriptional activation. Disruption of any of these functions can contribute to genome instability, inflammatory signaling, and tumorigenesis. BRCA2 is a central tumor suppressor protein best known for its roles
Lucia Alvaro‐Aranda   +2 more
wiley   +1 more source

Computer Modeling Explains the Structural Reasons for the Difference in Reactivity of Amine Transaminases Regarding Prochiral Methylketones. [PDF]

open access: yesInt J Mol Sci, 2022
Teixeira IS   +6 more
europepmc   +1 more source

Artificial molecular machines and motors—Design and control of nanoscale motion

open access: yesFEBS Letters, EarlyView.
Molecules are constantly moving because of thermal fluctuations, but random motion alone cannot be exploited to perform directional tasks. Artificial molecular machines use chemical, electrical, or light energy to bias this motion. Molecular shuttles, rotary motors, and supramolecular pumps illustrate how nanoscale movement can be controlled and ...
Leonardo Andreoni, Alberto Credi
wiley   +1 more source

Concurrent Micra Leadless Pacemaker Implantation and AVN Ablation: Computer Modeling of Novel Risk Mitigation Strategy. [PDF]

open access: yesPacing Clin Electrophysiol
Nelson DW   +6 more
europepmc   +1 more source

Computer Modeling of Clot Retrieval-Circle of Willis. [PDF]

open access: yesFront Neurol, 2020
Phan TG   +6 more
europepmc   +1 more source

Visualizing and Modeling Categorical Time Series Data

open access: yes, 1995
Categorical time series data can not be effectively visualized and modeled using methods developed for ordinary data. The arbitrary mapping of categorical data to ordinal values can have a number of undesirable consequences.
Ribler, Randy   +2 more
core  

A context‐dependent modulatory role for eIF6 in acquired resistance to vemurafenib in melanoma

open access: yesFEBS Letters, EarlyView.
Acquired resistance to vemurafenib upregulates the translation factor eIF6 in melanoma cells. Silencing eIF6 in resistant cells reduces proliferation and partially restores drug sensitivity, whereas its overexpression increases sensitivity across melanoma lines regardless of BRAF status, via modulation of mTOR, S6K, and MAPK signaling.
George Kyriakopoulos   +9 more
wiley   +1 more source

Symposium proposal computer-based modeling in science: the case of stagecast creator

open access: yes, 2005
Περιέχει τη περίληψηThere is a longstanding awareness of the need to help students learn about models and modeling in science, and computer-based programming environments are promising tools for this.
Constantinou, Constantinos P.   +4 more
core  

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