Results 241 to 250 of about 1,880,786 (300)

Transcriptional profiling of circulating extracellular vesicles from prebiopsy prostate cancer patients

Molecular Oncology, EarlyView.
RNA profiling of circulating extracellular vesicles (EVs) from blood samples of men undergoing prostate biopsy identifies transcripts associated with clinically significant prostate cancer. Integrative analysis with public tumor datasets links EV‐derived gene signatures to tumor stage and progression‐free survival, highlighting CASP3, XRCC2, and RIT1 ...
Stefan Werner, Pierre Tennstedt, Randi C. Pose, Christian Müller, Katharina Besler, Svenja Schneegans, Malik Alawi, Marie C. Roesch, Sven Peine, Desiree Bonci, Joanna Budna‐Tukan, Evi Lianidou, Catherine Alix‐Panabières, Derya Tilki, Klaus Pantel   +14 more
wiley   +1 more source

Rethinking plastic waste: innovations in enzymatic breakdown of oil‐based polyesters and bioplastics

FEBS Open Bio, EarlyView.
Plastic pollution remains a critical environmental challenge, and current mechanical and chemical recycling methods are insufficient to achieve a fully circular economy. This review highlights recent breakthroughs in the enzymatic depolymerization of both oil‐derived polyesters and bioplastics, including high‐throughput protein engineering, de novo ...
Elena Rosini, Nicolò Antonelli, Gianluca Molla   +2 more
wiley   +1 more source

Overview of molecular signatures of senescence and associated resources: pros and cons

FEBS Open Bio, EarlyView.
Cells can enter a stress response state termed cellular senescence that is involved in various diseases and aging. Detecting these cells is challenging due to the lack of universal biomarkers. This review presents the current state of senescence identification, from biomarkers to molecular signatures, compares tools and approaches, and highlights ...
Orestis A. Ntintas, Sylvia Vagena, Pavlos Pantelis, Giorgos Theocharous, Russel Petty, Konstantinos Evangelou, Vassilis G. Gorgoulis   +6 more
wiley   +1 more source

Targeting TNBC: core–shell polycationic polyurea dendrimers with inherent anticancer activity

FEBS Open Bio, EarlyView.
Core–shell polycationic PURE dendrimers were tested in TNBC‐derived tumor models. Both formulations selectively targeted TNBC and effectively reduced tumor volume. PUREG4‐OEI48 suppressed tumor growth without detectable toxicity, whereas PUREG4‐OCEI24, despite showing efficacy, induced hepatic toxicity.
Adriana Cruz, Bruna Abreu, Cindy Mendes, Catarina Freitas‐Dias, Filipe Gonçalves, Fernanda Silva, José Ramalho, Saudade André, Vasco D. B. Bonifácio, Jacinta Serpa   +9 more
wiley   +1 more source

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Computational Modeling in Human-Computer Interaction

Extended Abstracts of the 2019 CHI Conference on Human Factors in Computing Systems, 2019
We propose a workshop on rapidly emerging topic of Computational Modeling in HCI to address the challenges of increasing complexity of human behaviors we are able to track and collect today. The goal of this workshop is to reconcile two seemingly competing approaches to computational modeling: theoretical modeling, which seeks to explain behaviors vs ...
Nikola Banovic, Antti Oulasvirta, Per Ola Kristensson   +2 more
openaire   +1 more source

Models of Computation

2017
This book presents in their basic form the most important models of computation, their basic programming paradigms, and their mathematical descriptions, both concrete and abstract. Each model is accompanied by relevant formal techniques for reasoning on it and for proving some properties.
BRUNI, ROBERTO, MONTANARI, UGO GIOVANNI ERASMO   +1 more
openaire   +2 more sources

Computational decompression models

International Journal of Bio-Medical Computing, 1987
Early computational models for decompression are based on supersaturation assumptions for dissolved gases. Such models, and our understanding of decompression biophysics, have been extended in the past 20 years by analyses of phase separation of gases.
openaire   +2 more sources

Model-Based Computation

Natural Computing, 2016
zbMATH Open Web Interface contents unavailable due to conflicting licenses.
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Modelling: Computing cancer

Nature, 2012
Software models of complex tissues and disease are yielding a better understanding of cancer and suggesting potential treatments.
openaire   +2 more sources

Computability and Computable Models

2007
The intuitive notion of computability was formalized in the XXth century, which strongly affected the development of mathematics and applications, new computational technologies, various aspects of the theory of knowledge, etc. A rigorous mathematical definition of computability and algorithm generated new approaches to understanding a solution to a ...
openaire   +1 more source