Results 111 to 120 of about 1,267,704 (337)

Transcriptome‐wide analysis of circRNA and RBP profiles and their molecular relevance for GBM

open access: yesMolecular Oncology, EarlyView.
CircRNAs are differentially expressed in glioblastoma primary tumors and might serve as therapeutic targets and diagnostic markers. The investigation of circRNA and RNA‐binding proteins (RBPs) interactions shows that distinct RBPs play a role in circRNA biogenesis and function.
Julia Latowska‐Łysiak   +14 more
wiley   +1 more source

Targeting the MDM2‐MDM4 interaction interface reveals an otherwise therapeutically active wild‐type p53 in colorectal cancer

open access: yesMolecular Oncology, EarlyView.
This study investigates an alternative approach to reactivating the oncosuppressor p53 in cancer. A short peptide targeting the association of the two p53 inhibitors, MDM2 and MDM4, induces an otherwise therapeutically active p53 with unique features that promote cell death and potentially reduce toxicity towards proliferating nontumor cells.
Sonia Valentini   +10 more
wiley   +1 more source

Management and Orchestration of Network Slices in 5G, Fog, Edge and Clouds [PDF]

open access: yesarXiv, 2018
Network slicing allows network operators to build multiple isolated virtual networks on a shared physical network to accommodate a wide variety of services and applications. With network slicing, service providers can provide a cost-efficient solution towards meeting diverse performance requirements of deployed applications and services.
arxiv  

A digital communication network for computers giving rapid response at remote terminals [PDF]

open access: bronze, 1967
D. W. Davies   +3 more
openalex   +1 more source

Exploration of heterogeneity and recurrence signatures in hepatocellular carcinoma

open access: yesMolecular Oncology, EarlyView.
This study leveraged public datasets and integrative bioinformatic analysis to dissect malignant cell heterogeneity between relapsed and primary HCC, focusing on intercellular communication, differentiation status, metabolic activity, and transcriptomic profiles.
Wen‐Jing Wu   +15 more
wiley   +1 more source

Performance Metrics Analysis of Torus Embedded Hypercube Interconnection Network [PDF]

open access: yesIJCSE Volume 1 Issue 2 2009 78-80, 2009
Advantages of hypercube network and torus topology are used to derive an embedded architecture for product network known as torus embedded hypercube scalable interconnection network. This paper analyzes torus embedded hypercube network pertinent to parallel architecture. The network metrics are used to show how good embedded network can be designed for
arxiv  

The atypical KRASQ22K mutation directs TGF‐β response towards partial epithelial‐to‐mesenchymal transition in patient‐derived colorectal cancer tumoroids

open access: yesMolecular Oncology, EarlyView.
TGF‐β has a complex role in cancer, exhibiting both tumor‐suppressive and tumor‐promoting properties. Using a series of differentiated tumoroids, derived from different stages and mutational background of colorectal cancer patients, we replicate this duality of TGF‐β in vitro. Notably, the atypical but highly aggressive KRASQ22K mutation rendered early‐
Theresia Mair   +17 more
wiley   +1 more source

Evaluating model and simulation analyzing for P2P Churn

open access: yesTongxin xuebao, 2007
Most P2P algorithms based on distributed Hash table(DHT) faced Churn,which was caused by the continuous process of node joining and failure.A Churn evaluating model was proposed and its formulized description,which could give some important instructions ...
YANG Dong, DONG Ping, ZHANG Hong-ke
doaj  

Derivation of Network Reprogramming Protocol with Z3 [PDF]

open access: yesarXiv, 2017
Networks protocols are the heart of communication networks. An efficient network protocol does maximum utilization of the underlying network capabilities. Network Protocol synthesis is the process of synthesizing or deriving network specific protocols from the requirements of a given specific network.
arxiv  

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