Results 61 to 70 of about 11,345,084 (383)

The anti‐CRISPR protein AcrIE8.1 inhibits the type I‐E CRISPR‐Cas system by directly binding to the Cascade subunit Cas11

open access: yesFEBS Letters, EarlyView.
In this study, we present the structure of AcrIE8.1, a previously uncharacterized anti‐CRISPR protein that inhibits the type I‐E CRISPR‐Cas system. Through a combination of structural and biochemical analyses, we demonstrate that AcrIE8.1 directly binds to the Cas11 subunit of the Cascade complex to inhibit the CRISPR‐Cas system.
Young Woo Kang, Hyun Ho Park
wiley   +1 more source

Computer program to generate attitude error equations for a gimballed platform [PDF]

open access: yes, 1972
Computer program for solving attitude error equations related to gimballed platform is described. Program generates matrix elements of attitude error equations when initial matrices and trigonometric identities have been defined.
Hall, W. A., Jr.   +2 more
core   +1 more source

The IQ‐compete assay for measuring mitochondrial protein import efficiencies in living yeast cells

open access: yesFEBS Letters, EarlyView.
The efficiency of mitochondrial protein import depends on the properties of the newly synthesized precursor proteins. The Import and de‐Quenching Competition (IQ‐compete) assay is a novel method to monitor the import efficiency of different proteins by fluorescence in living yeast cells.
Yasmin Hoffman   +3 more
wiley   +1 more source

Validation of a decision support system for determining the severity of scoliotic spinal deformity using radiographic image analysis

open access: yesХирургия позвоночника
Objective. To prove the possibility of using a domestic computer program in clinical practice to determine Cobb angle by means of comparative analysis of the obtained automated data with the data of manual measurement by specialists.
G.A. Lein   +3 more
doaj   +1 more source

Method for predicting rotor free-wake positions and the resulting rotor blade airloads [PDF]

open access: yes, 1973
Computer program has been designed and written to predict rotor free-wake positions and resulting rotor blade airloads without requiring time-consuming and tedious calculations.
Deen, D., Mantay, W. R., Sadler, S. G.
core   +1 more source

Targeting EZH2 reverses thyroid cell dedifferentiation and enhances iodide uptake in anaplastic thyroid cancer

open access: yesFEBS Letters, EarlyView.
Anaplastic thyroid cancer (ATC) lacks iodide uptake ability due to MAPK activation increasing the expression of the histone methyltransferase EZH2, which represses thyroid differentiation genes (TDGs) such as the sodium iodide symporter (NIS). Dual inhibition of MAPK (U0126) and EZH2 (EPZ6438/Tazemetostat) reverses this mechanism, thus restoring TDG ...
Diego Claro de Mello   +6 more
wiley   +1 more source

TEV—A Program for the Determination of the Thermal Expansion Tensor from Diffraction Data

open access: yesCrystals, 2015
TEV (Thermal Expansion Visualizing) is a user-friendly program for the calculation of the thermal expansion tensor αij from diffraction data. Unit cell parameters determined from temperature dependent data collections can be provided as input.
Thomas Langreiter, Volker Kahlenberg
doaj   +1 more source

Circuitry selectively limits data storage in general purpose computer [PDF]

open access: yes, 1969
Circuitry limits storage in the memory of a stored program general purpose digital computer by permitting storage or writing to certain, specified areas of memory.
Slopper, D. K.
core   +1 more source

By dawn or dusk—how circadian timing rewrites bacterial infection outcomes

open access: yesFEBS Letters, EarlyView.
The circadian clock shapes immune function, yet its influence on infection outcomes is only beginning to be understood. This review highlights how circadian timing alters host responses to the bacterial pathogens Salmonella enterica, Listeria monocytogenes, and Streptococcus pneumoniae revealing that the effectiveness of immune defense depends not only
Devons Mo   +2 more
wiley   +1 more source

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