Results 151 to 160 of about 183,807 (295)
Science vs. science: the complexities of interdisciplinary research
, 2013 Human-Computer Interaction and Web Science are radically interdisciplinary fields, but what does this mean in practical terms? Undertaking research (and writing papers) that encompass multiple disciplinary perspectives and methods is a serious challenge ...
Kaye, Jofish +3 more
core
Molecular Oncology, EarlyView.Intratumour heterogeneity complicates precision management of advanced endometrial cancer. Circulating tumor DNA (ctDNA) offers a minimally invasive strategy to capture tumor evolution and therapeutic resistance. Here, we compare tumor‐agnostic NGS with tumor‐informed ddPCR, outlining their relative sensitivity, concordance, and clinical implications ...
Carlos Casas‐Arozamena +15 more
wiley +1 more source
Some connections between set theory and computer science
, 1993 . Methods originating in theoreticar computer science for shoiving that certain decision probrems are Np-complete have also been used to show that certain compactness theorems are equivalent in ZF set theory to the Boolean Prime ldear rheorem (BpI ...
Robert Cowen
core
Molecular Oncology, EarlyView.Circulating tumor cells (CTCs) and plasma cell‐free DNA (cfDNA) were analyzed to detect ESR1 mutations and methylation in patients with advanced breast cancer. CTC‐derived DNA showed higher sensitivity for mutation detection and revealed complementary genetic and epigenetic alterations, highlighting the added value of CTC analysis for understanding ...
Dimitra Stergiopoulou +12 more
wiley +1 more source
Globally Convergent Homotopy Methods for the DC Operating PointProblem
, 1990 Accurate and efficient computer simulation of a proposed design for an integrated circuit ("chip") is essential because of the difficulty and expense of building prototypes for such devices.
Fang, San-Chin +3 more
core
Interpreting the effects of DNA polymerase variants at the structural level
Molecular Oncology, EarlyView.Using MAVISp and molecular dynamics simulations, we analyzed over 60 000 missense variants in POLE and POLD1 from ClinVar, COSMIC, cBioPortal, and saturation mutagenesis. Identified mechanistic indicators, including stability, binding, and long‐range, enable structural interpretation, providing ACMG‐like evidence for possible reclassification of VUS ...
Matteo Arnaudi +7 more
wiley +1 more source
Applying Visualization for Teaching Scheduling Algorithms in Computer Science
, 2017 Using animation in teaching has become more popular in the twenty-first century in universities and education organizations. It makes understanding the challenging concepts much easier than using the traditional methods to explain them.
Alkhazl, Fatimah
core
Learning by generation in computer science education
Journal of Computer Science and Technology, 2004 The use of generic and generative methods for the development and application of interactive educational software is a relatively unexplored area in industry and education. Advantages of generic and generative techniques are, among other things, the high
Andreas Kerren
doaj
Molecular Oncology, EarlyView.Ixazomib inhibits proteasome‐mediated degradation of topoisomerase I induced by irinotecan, thereby restoring drug sensitivity and promoting tumor cell death in colorectal cancer. Irinotecan, a topoisomerase I (topoI) inhibitor, is widely used for colorectal cancer, but resistance remains a major clinical challenge.
Yuho Ebata +10 more
wiley +1 more source
Molecular Oncology, EarlyView.Both cg12821679MAPRE3 methylation and MAPRE3 expression are significantly associated with overall survival (OS) of non‐small cell lung cancer. Meanwhile, MAPRE3 expression significantly modified the effect of smoking cessation on OS. Smoking cessation benefits OS merely for patients with high MAPRE3 expression.
Chao Chen +14 more
wiley +1 more source