Results 121 to 130 of about 10,928,440 (381)
The anabolic steroid stanozolol is a potent inhibitor of human MutT homolog 1
FEBS Letters, EarlyView.MutT homolog 1 (MTH1) is a member of the NUDIX superfamily of enzymes and is an anticancer drug target. We show that stanozolol (Stz), an anabolic steroid, is an unexpected nanomolar inhibitor of MTH1. The X‐ray crystal structure of the human MTH1–Stz complex reveals a unique binding scaffold that could be utilized for future inhibitor development ...
Emma Scaletti Hutchinson +7 more
wiley +1 more source
COLLEGE : a collaborative on-line lecture environment for group and individual eLearning [PDF]
, 2005 COLLEGE is a platform for the development and delivery of interactive learning content for individual students or groups and will be built during 2005-2007.
3rd Computer Science Annual Workshop (CSAW’05) +1 more
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Is computer science dying? [PDF]
2016 International Conference on Embedded Computer Systems: Architectures, Modeling and Simulation (SAMOS), 2016 This talk discusses some positive and negative trends in the field. It briefly examines some case studies, and finally discusses things that we as a community could do better.
openaire +3 more sources
Aβ42 promotes the aggregation of α‐synuclein splice isoforms via heterogeneous nucleation
FEBS Letters, EarlyView.The aggregation of amyloid‐β (Aβ) and α‐synuclein (αSyn) is associated with Alzheimer's and Parkinson's diseases. This study reveals that Aβ aggregates serve as potent nucleation sites for the aggregation of αSyn and its splice isoforms, shedding light on the intricate interplay between these two pathogenic proteins.
Alexander Röntgen +2 more
wiley +1 more source
The role of programming in a Ph.D. computer science program [PDF]
, 1969 Bruce W. Arden
openalex +1 more source
Distributed application reliability on unstable, dynamic, P2P-based platforms [PDF]
, 2004 Application developers are used to a homogeneous, reliable and easily manageable platform on which to deploy their applications. Increasingly however, the need for a highly scalable distributed environment is becoming prevalent.
2nd Computer Science Annual Workshop (CSAW’04) +1 more
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2014 IEEE Pacific Visualization Symposium, 2014 10 pages, 8 figures, live version and source code available at mocs.cs.arizona ...
Stephen G. Kobourov, Daniel Fried
openaire +3 more sources
ERBIN limits epithelial cell plasticity via suppression of TGF‐β signaling
FEBS Letters, EarlyView.In breast and lung cancer patients, low ERBIN expression correlates with poor clinical outcomes. Here, we show that ERBIN inhibits TGF‐β‐induced epithelial‐to‐mesenchymal transition in NMuMG breast and A549 lung adenocarcinoma cell lines. ERBIN suppresses TGF‐β/SMAD signaling and reduces TGF‐β‐induced ERK phosphorylation.
Chao Li +3 more
wiley +1 more source
Mathematics and Computer Science in Biology and Medicine [PDF]
, 1966 Lisa Payne
openalex +1 more source
Simulo Tempestas : a simulation tool for hydrological modelling [PDF]
, 2004 Man’s existence has clearly interfered with nature. Ever since man appeared on the face of our planet, the landscape was adapted to make it a more habitable environment. Although early humans transformed land to accommodate their dwellings and livestock,
2nd Computer Science Annual Workshop (CSAW’04) +1 more
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