Results 121 to 130 of about 10,839,512 (369)

In vivo evidence for glycyl radical insertion into a catalytically inactive variant of pyruvate formate‐lyase

open access: yesFEBS Letters, EarlyView.
Dimeric pyruvate formate‐lyase cleaves pyruvate using a radical‐based mechanism. G734 serves as a radical storage location, and the radical is transferred to the catalytic C419 residue. Mutation of the C418‐C419 pair causes loss of enzyme activity, but does not impede radical introduction onto G734. Therefore, cis‐ but not trans‐radical transfer occurs
Michelle Kammel   +2 more
wiley   +1 more source

Dealing with the hypothetical in contracts [PDF]

open access: yes, 2012
The notion of a contract as an agreement regulating the behaviour of two (or more) parties has long been studied, with most work focusing on the interaction between the contract and the parties.
Computer Science Annual Workshop CSAW’12   +1 more
core  

P‐glycoprotein modulates the fluidity gradient of the plasma membrane of multidrug resistant CHO cells

open access: yesFEBS Letters, EarlyView.
To explore the impact of the overexpression of the multidrug‐transporter P‐glycoprotein (ABCB1) on membrane fluidity, we compared the transversal gradient of mobility and microviscosity in plasma membranes of drug‐sensitive Chinese hamster ovary cells (AuxB1) and their multidrug‐resistant derivatives (B30) using the fluorescent n‐(9‐anthroyloxy) fatty ...
Roger Busche   +2 more
wiley   +1 more source

Open-domain surface-based question answering system [PDF]

open access: yes, 2003
This paper considers a surface-based question answering system for an open- domain solution. It analyzes the current progress that has been done in this area so far, while as well describes a methodology of answering questions by using information ...
1st Computer Science Annual Workshop (CSAW’03)   +1 more
core  

Disruption of SETD3‐mediated histidine‐73 methylation by the BWCFF‐associated β‐actin G74S mutation

open access: yesFEBS Letters, EarlyView.
The β‐actin G74S mutation causes altered interaction of actin with SETD3, reducing histidine‐73 methylation efficiency and forming two distinct actin variants. The variable ratio of these variants across cell types and developmental stages contributes to tissue‐specific phenotypical changes. This imbalance may impair actin dynamics and mechanosensitive
Anja Marquardt   +8 more
wiley   +1 more source

Evolving viable pitch contours [PDF]

open access: yes, 2006
At a very basic level, a piece of music can be defined as an organised arrangement of sounds occurring both sequentially (as in melody) and concurrently (as in harmony).
4th Computer Science Annual Workshop (CSAW’06)   +1 more
core  

The Case for Improving U.S. Computer Science Education

open access: yes, 2016
Since computer science became an academic discipline in the late 1960s, the level of interest in the field and the number of students taking courses has grown in fits and starts.
A. Nager, R. Atkinson
semanticscholar   +1 more source

Home - About - Disclaimer - Privacy