Results 141 to 150 of about 30,070,977 (302)

Modelling stem cell differentiation related processes—A practical overview for biologists

open access: yesFEBS Letters, EarlyView.
Stem cell differentiation is complex and difficult to control experimentally. This review introduces suitable computational modelling approaches that can support stem cell research, from mechanistic ODE and abstract models to multiscale and deep learning methods.
Ricco Zeegelaar   +4 more
wiley   +1 more source

Design and analysis strategies for robust microbiome ageing research

open access: yesFEBS Letters, EarlyView.
The gut microbiome changes with age and associates with age‐related morbidity and mortality, establishing it as a potential biomarker and intervention target for ageing. Realising this potential requires methodological rigour, yet distinguishing biological signals from methodological artefacts remains challenging across cohorts. This review provides an
Mark Olenik   +5 more
wiley   +1 more source

Personal Reflections on 50 Years of Scientific Computing: 1967–2017

open access: yes, 2017
Computer hardware, software, numerical algorithms, and science and engineering applications are traced for a half century from the author's ...
Watson, Layne T.
core  

Computer science and computer engineering research equipment [PDF]

open access: yes
This grant supported acquisition of a minicomputer system for departmental research. The equipment selected is a DEC VAX-11/750 system, installed in remodeled space in the Computer Science (formerly Farm Crops) Building.
Tonge, Fred M.
core   +2 more sources

ABL kinase‐dependent phosphorylation of SH proteins promotes their direct interaction with CRK family SH2 domains

open access: yesFEBS Letters, EarlyView.
CT10 regulator of kinase (CRK) and CRK‐Like (CRKL) are signaling adaptors driving cell adhesion, motility, differentiation, and proliferation. SH2‐domain containing (SH) proteins are enriched in YXXP motifs which when phosphorylated create preferred binding sites for CRK family SH2 domains.
Phoebe M. Cousens   +8 more
wiley   +1 more source

UA66/3/2 Computer Science Alumni Newsletter, Vol. 5 [PDF]

open access: yes, 1989
Newsletter created by WKU Computer Science for the alumni of the ...
WKU Computer Science
core  

Reconstructing enzyme evolution by protein engineering

open access: yesFEBS Letters, EarlyView.
Natural enzyme evolution can be retraced by protein engineering methods such as directed evolution, rational design, and ancestral sequence reconstruction. These approaches reveal how enzymes emerged from ligand‐binding scaffolds, developed varying substrate preferences, formed oligomeric complexes, adapted to environmental changes, and evolved novel ...
Lukas Drexler   +2 more
wiley   +1 more source

Computer Science Concepts - Complexity

open access: yes, 2010
This lecture forms part of the "Complexity" topic of the Computer Science Concepts module.
Rong Yang   +2 more
core  

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