Results 231 to 240 of about 5,144,087 (289)

Establishment of a humanized patient‐derived xenograft mouse model of high‐grade serous ovarian cancer for preclinical evaluation of combination immunotherapy

Molecular Oncology, EarlyView.
We have established a humanized orthotopic patient‐derived xenograft (Hu‐oPDX) mouse model of high‐grade serous ovarian cancer (HGSOC) that recapitulates human tumor–immune interactions. Using combined anti‐PD‐L1/anti‐CD73 immunotherapy, we demonstrate the model's improved biological relevance and enhanced translational value for preclinical ...
Luka Tandaric, Line Bjørge, Martine Rott Lode, Cecilie Fredvik Torkildsen, Pia Aehnlich, Rammah Elnour, Daniela Elena Costea, Lars Andreas Akslen, Liv Cecilie Vestrheim Thomsen, Emmet McCormack, Katrin Kleinmanns   +10 more
wiley   +1 more source

Hippo pathway at the crossroads of stemness and therapeutic resistance in breast cancer

Molecular Oncology, EarlyView.
Dysregulation of the Hippo pathway drives nuclear accumulation of YAP/TAZ, activating stemness‐related transcriptional programs that sustain breast cancer stemness and fuel therapeutic resistance across subtypes, underscoring Hippo signaling as a targetable vulnerability. Figure created and edited with BioRender.com.
Giulia Schiavoni, Antonella Palmese, Stefano Scalera, Laura Cipriani, Davide Mascolo, Patrizia Vici, Teresa Arcuri, Lorena Filomeno, Eriseld Krasniqi, Giovanni Blandino, Giulia Bon, Marcello Maugeri‐Saccà   +11 more
wiley   +1 more source

Deciphering transcriptional plasticity in pancreatic ductal adenocarcinoma reveals alterations in sensory neuron innervation

Molecular Oncology, EarlyView.
Pancreatic sensory neurons innervating healthy and PDAC tissue were retrogradely labeled and profiled by single‐cell RNA sequencing. Tumor‐associated innervation showed a dominant neurofilament‐positive subtype, altered mitochondrial gene signatures, and reduced non‐peptidergic neurons.
Elena Genova, Michele Montrone, Uday Rangaswamy, Francesco Diversi, Irene Schiavo, Denise Ferrarini, Roberta Di Florio, Irene Longo, Michele Coscia, Nicola Zamboni, Giorgia Demontis, Lisa Veghini, Vincenzo Corbo, Remo Sanges, Paul Heppenstall   +14 more
wiley   +1 more source

Some of the next articles are maybe not open access.

Related searches:

Recognizing Computational Science

Science, 2006
There are prestigious international awards that recognize the role of theory and experiment in science and mathematics, but there are no awards of a similar stature that explicitly recognize the role of computational science in a scientific field. In my view, this is a serious omission. In 1945,
openaire   +2 more sources

Science, computational science, and computer science

Communications of the ACM, 1993
We describe computational science as an interdisciplinary approach to doing science on computers. Our purpose is to introduce computational science as a legitimate interest of computer scientists.We present a possible foundation for computational science.
openaire   +1 more source

Computational social science

WIREs Computational Statistics, 2010
AbstractThe social sciences investigate human and social dynamics and organization at all levels of analysis (consilience), including cognition, decision making, behavior, groups, organizations, societies, and the world system. Computational social science is the integrated, interdisciplinary pursuit of social inquiry with emphasis on information ...
openaire   +1 more source

Computational social science ≠ computer science + social data

Communications of the ACM, 2018
The important intersection of computer science and social science.
openaire   +1 more source

Frontiers for computer science in computational science

Proceedings of the 30th annual Southeast regional conference on - ACM-SE 30, 1992
Computational Science (CPLSC) is an emerging discipline characterized by interdisciplinary team efforts and high precision computing. Computer science is just one dimension of this new discipline.We describe the Clemson program focusing on three major issues: (i) what are the foundations of CPLSC, (ii) how are we to educate computer science students in
openaire   +1 more source

Is computer science science?

Communications of the ACM, 2005
Computer science meets every criterion for being a science, but it has a self-inflicted credibility problem.
openaire   +1 more source

Computer science

ACM SIGCSE Bulletin, 1998
A traditional computer science program, in the liberal arts tradition and environment, has been in existence at Allegheny College for many years. The program was designed and adopted in 1979 [6] and the ideas and structure of that program became a substantial contribution to the LACS "Model Curriculum" developed in the early '80s and ...
openaire   +1 more source