Results 71 to 80 of about 31,041 (265)

Theoretical Computer Science for the Working Category Theorist

open access: yes, 2017
Theoretical computer science discusses foundational issues about computations. It asks and answers questions such as “What is a computation?”, “What is computable?”, “What is efficiently computable?", "What is information?", "What is random?", "What is ...
Yanofsky, NS
core  

Pharmacological inhibition of the PERK pathway modulates hepatocellular carcinoma growth and immune signaling

open access: yesFEBS Open Bio, EarlyView.
Pharmacological inhibition of PERK in a DEN‐induced mouse model of liver cancer does not reduce tumor burden but alters cellular stress signaling. Despite blocking PERK activity, downstream stress responses, including CHOP expression, remain active, suggesting compensatory mechanisms within the unfolded protein response that may influence tumor ...
Ada Lerma‐Clavero   +5 more
wiley   +1 more source

Models of computation: A numeric analysis and performance evaluation

open access: yes
This research seeks to better understand what drives performance in computation. To develop this understanding the researcher investigates the literature on computational performance within the classical and quantum paradigm for both binary and multi ...
Verschueren, Ricardo
core  

Sudden anaerobization in Amphibacillus xylanus increases intracellular labile ferrous iron and inhibits cell growth

open access: yesFEBS Open Bio, EarlyView.
Abruptly changing from aerobic to anaerobic conditions (sudden anaerobization) induced growth inhibition and a significant increase in intracellular labile ferrous iron in the aerotolerant anaerobe Amphibacillus xylanus. We found that free flavins mediate efficient electron transfer from NADH to ferric iron under anaerobic conditions, suggesting that ...
Shinya Kimata   +13 more
wiley   +1 more source

UiO‐66 metal–organic frameworks in biomedicine: From structural tunability to bioimaging, photodiagnostics, and photodynamic cancer therapy

open access: yesFEBS Open Bio, EarlyView.
UiO‐66(Zr) metal–organic frameworks are chemically stable, biocompatible, and highly tunable nanomaterials. Their modular structure enables controlled drug delivery, multimodal bioimaging, and light‐activated photodynamic therapy, supporting integrated diagnostic and therapeutic (theranostic) applications in cancer and biomedical research.
Veronika Huntošová   +2 more
wiley   +1 more source

Bigraph Metaprogramming for Distributed Computation

open access: yes, 2010
Ubiquitous computing is a paradigm that emphasises integration of computing activities into the fabric of everyday life. With the increasing availability of small, cheap computing devices, the ubiquitous computing model seems more and more likely to ...
Perrone, Gian David
core  

Construction of a support tool for the design of the activity structures based computer system architectures [PDF]

open access: yes, 1986
This thesis was submitted for the degree of Doctor of Philosophy and was awarded by Brunel University.This thesis is a reapproachment of diverse design concepts, brought to bear upon the computer system engineering problem of identification and control ...
Mohamad, Sabah Mohamad Amin
core  

Topology, Domain Theory and Theoretical Computer Science

open access: yes, 1998
In this paper, we survey the use of order-theoretic topology in theoretical computer science, with an emphasis on applications of domain theory. Our focus is on the uses of order-theoretic topology in programming language semantics, and on problems of ...
Michael Mislove, Mislove, Michael W.
core   +1 more source

Directed evolution of enzymes at the crossroads of tradition and innovation

open access: yesFEBS Open Bio, EarlyView.
An iterative cycle of data‐driven enzyme optimization comprising four stages: genetic diversification of a template enzyme, expression of protein variants, high‐throughput evaluation, and machine‐learning‐guided redesign of the next variant library.
Maria Tomkova   +2 more
wiley   +1 more source

Computation Structures

open access: yes, 2010
Introduces architecture of digital systems, emphasizing structural principles common to a wide range of technologies. Multilevel implementation strategies; definition of new primitives (e.g., gates, instructions, procedures, and processes) and their ...
Ward, Stephen A.   +2 more
core  

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