Results 21 to 30 of about 745,627 (235)

On Iterated Dominance, Matrix Elimination, and Matched Paths [PDF]

open access: yes, 2010
We study computational problems arising from the iterated removal of weakly dominated actions in anonymous games. Our main result shows that it is NP-complete to decide whether an anonymous game with three actions can be solved via iterated weak ...
Brandt, Felix   +2 more
core   +5 more sources

Complexity of a modelling exercise: A discussion of the role of computer simulation in complex system science [PDF]

open access: yesComplexity, 2008
AbstractShifting the emphasis from a model to a modeling task, which involves both a computer model and a modeler, we ask what makes a problem complex. We propose that a modeling task can be seen as a set of questions‐and‐answers, nested at multiple levels.
Fabio Boschetti   +2 more
openaire   +1 more source

An Algorithmic Argument for Nonadaptive Query Complexity Lower Bounds on Advised Quantum Computation

open access: yes, 2003
This paper employs a powerful argument, called an algorithmic argument, to prove lower bounds of the quantum query complexity of a multiple-block ordered search problem in which, given a block number i, we are to find a location of a target keyword in an
A. Ambainis   +9 more
core   +3 more sources

Applying computational complexity to the emergence of classicality [PDF]

open access: yes, 2013
Can the computational complexity theory of computer science and mathematics say something new about unresolved problems in quantum physics? Particularly, can the P versus NP question in the computational complexity theory be a factor in the elucidation ...
Bolotin, Arkady
core  

Quantum Hamiltonian Complexity

open access: yes, 2015
Constraint satisfaction problems are a central pillar of modern computational complexity theory. This survey provides an introduction to the rapidly growing field of Quantum Hamiltonian Complexity, which includes the study of quantum constraint ...
Gharibian, Sevag   +3 more
core   +1 more source

Transferrin receptor 1‐mediated iron uptake supports thermogenic activation in human cervical‐derived adipocytes

open access: yesFEBS Letters, EarlyView.
In this study, we found that human cervical‐derived adipocytes maintain intracellular iron level by regulating the expression of iron transport‐related proteins during adrenergic stimulation. Melanotransferrin is predicted to interact with transferrin receptor 1 based on in silico analysis.
Rahaf Alrifai   +9 more
wiley   +1 more source

Structural insights into an engineered feruloyl esterase with improved MHET degrading properties

open access: yesFEBS Letters, EarlyView.
A feruloyl esterase was engineered to mimic key features of MHETase, enhancing the degradation of PET oligomers. Structural and computational analysis reveal how a point mutation stabilizes the active site and reshapes the binding cleft, expading substrate scope.
Panagiota Karampa   +5 more
wiley   +1 more source

Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system

open access: yesFEBS Letters, EarlyView.
Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley   +1 more source

Cellular Automata Applications in Shortest Path Problem

open access: yes, 2017
Cellular Automata (CAs) are computational models that can capture the essential features of systems in which global behavior emerges from the collective effect of simple components, which interact locally.
A Macwan   +55 more
core   +1 more source

A methionine‐lined active site governs carbocation stabilization and product specificity in a bacterial terpene synthase

open access: yesFEBS Letters, EarlyView.
This study reveals a unique active site enriched in methionine residues and demonstrates that these residues play a critical role by stabilizing carbocation intermediates through novel sulfur–cation interactions. Structure‐guided mutagenesis further revealed variants with significantly altered product profiles, enhancing pseudopterosin formation. These
Marion Ringel   +13 more
wiley   +1 more source

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