Results 31 to 40 of about 32,412,941 (211)
Prospecting the protein design landscape
FEBS Letters, EarlyView.This review outlines the current state of various protein design approaches. We discuss the current possibilities enabled by recently released tools, highlight future avenues to pursue in protein design, and underscore the crucial role of key databases and resources for successful protein design workflows.
Jakob R. Riccabona +4 more
wiley +1 more source
Why Philosophers Should Care About Computational Complexity [PDF]
, 2011 One might think that, once we know something is computable, how efficiently it can be computed is a practical question with little further philosophical importance. In this essay, I offer a detailed case that one would be wrong.
Scott Aaronson, Aaronson, Scott
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Department of Computer Science newsletter 2022
, 2022 A Newsletter for Friends and Supporters of the Mines Computer Science Department.
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Going viral − Virus‐targeting nanobodies for research, diagnostics and therapy
FEBS Letters, EarlyView.The increasing prevalence of viral diseases represents a major threat for global human health. Nanobodies, small binding fragments derived from camelid heavy‐chain antibodies, offer versatile tools for viral research, diagnostics, and antiviral therapy.
Domenic Ebert, Ulrich Rothbauer
wiley +1 more source
FEBS Letters, EarlyView.Vacuolar H+‐ATPase (V‐ATPase) is a multisubunit rotary proton pump that acidifies intracellular compartments. Using elastic network models, we identified conserved hinge residues that govern its large‐scale functional motions. We show that intrinsically encoded ‘soft modes’ drive critical functional transitions, including rotary catalysis and ...
Diksha Parwana +3 more
wiley +1 more source
Computational Sciences Learning Project for Pre-university Students
, 2007 7th International Conference on Computational Science (ICCS 2007) -- MAY 27-30, 2007 -- Beijing, PEOPLES R CHINAIt is quite useful for high school students to study on computational sciences, especially for those who are planning to have a higher ...
Inceoglu, Mustafa Murat +3 more
core +1 more source
The role of miR‐335‐5p in the redifferentiation of BRAF p.V600E thyroid cancers
Molecular Oncology, EarlyView.The BRAF p.V600E mutation promotes thyroid cancer dedifferentiation and radioiodine resistance. Using a network approach, we identified miR‐335‐5p as a key regulator of BRAF‐mutated thyroid tumors. Restoring miR‐335‐5p increased thyroid‐specific gene expression and iodine uptake in cells and organoids.
Valeria Pecce +11 more
wiley +1 more source
Molecular Oncology, EarlyView.Combining osimertinib with the STING agonist ADU‐S100 activates innate and adaptive immunity to overcome the non‐inflamed microenvironment of Egfr‐mutant lung cancer. This combination increases NK and CD8+ T‐cell infiltration, associated with activation of the STING‐IRF3 pathway and local immunogenic cell death.
Jun Nishimura +19 more
wiley +1 more source
Developing a computational textiles curriculum to increase diversity in computer science [PDF]
, 2013 Thesis: M. Eng., Massachusetts Institute of Technology, Department of Electrical Engineering and Computer Science, 2013.This electronic version was submitted by the student author.
Qiu, Kanjun
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Low computational complexity variable block size (VBS) partitioning for motion estimation using the Walsh Hadamard transform (WHT) [PDF]
, 2009 Variable Block Size (VBS) based motion estimation has been adapted in state of the art video coding, such as H.264/AVC, VC-1. However, a low complexity H.264/AVC encoder cannot take advantage of VBS due to its power consumption requirements.
Kim, Chanyul +4 more
core +2 more sources