Results 31 to 40 of about 416,739 (258)

Algebraic geometry and representation theory in the study of matrix multiplication complexity and other problems in theoretical computer science

Differential Geometry and its Applications, 2022
Many fundamental questions in theoretical computer science are naturally expressed as special cases of the following problem: Let $G$ be a complex reductive group, let $V$ be a $G$-module, and let $v,w$ be elements of $V$. Determine if $w$ is in the $G$-orbit closure of $v$.
openaire   +2 more sources

Transferrin receptor 1‐mediated iron uptake supports thermogenic activation in human cervical‐derived adipocytes

FEBS Letters, EarlyView.
In this study, we found that human cervical‐derived adipocytes maintain intracellular iron level by regulating the expression of iron transport‐related proteins during adrenergic stimulation. Melanotransferrin is predicted to interact with transferrin receptor 1 based on in silico analysis.
Rahaf Alrifai, Mizuki Seo, Gyath Karadsheh, Fachrur Rizal Mahendra, Máté Á Demény, Ferenc Győry, János András Mótyán, László Fésüs, Endre Kristóf, Rini Arianti   +9 more
wiley   +1 more source

Engineering Art Galleries

, 2016
The Art Gallery Problem is one of the most well-known problems in Computational Geometry, with a rich history in the study of algorithms, complexity, and variants. Recently there has been a surge in experimental work on the problem.
A Bottino, A Bottino, A Deshpande, A Efrat, A Kröller, A Laurentini, AP Tomás, BJ Nilsson, D Schuchardt, DC Tozoni, DC Tozoni, DT Lee, E Balas, E Packer, J Kahn, J O’Rourke, J O’Rourke, J Urrutia, JE Beasley, K Chwa, K Mehlhorn, M Aigner, MC Couto, MC Couto, PD Tao, R Honsberger, S Eidenbenz, S Fisk, SK Ghosh, SP Fekete, SP Fekete, T Asano, TC Shermer, UM Erdem, V Chvátal, Y Amit   +35 more
core   +1 more source

An adaptive Cartesian embedded boundary approach for fluid simulations of two- and three-dimensional low temperature plasma filaments in complex geometries [PDF]

, 2019
We review a scalable two- and three-dimensional computer code for low-temperature plasma simulations in multi-material complex geometries. Our approach is based on embedded boundary (EB) finite volume discretizations of the minimal fluid-plasma model on ...
Marskar, Robert
core   +2 more sources

Structural insights into an engineered feruloyl esterase with improved MHET degrading properties

FEBS Letters, EarlyView.
A feruloyl esterase was engineered to mimic key features of MHETase, enhancing the degradation of PET oligomers. Structural and computational analysis reveal how a point mutation stabilizes the active site and reshapes the binding cleft, expading substrate scope.
Panagiota Karampa, Konstantinos Makryniotis, Theofani‐Iosifina Sousani, Evangelos Topakas, Vangelis Daskalakis, Maria Dimarogona   +5 more
wiley   +1 more source

A methionine‐lined active site governs carbocation stabilization and product specificity in a bacterial terpene synthase

FEBS Letters, EarlyView.
This study reveals a unique active site enriched in methionine residues and demonstrates that these residues play a critical role by stabilizing carbocation intermediates through novel sulfur–cation interactions. Structure‐guided mutagenesis further revealed variants with significantly altered product profiles, enhancing pseudopterosin formation. These
Marion Ringel, Carl P. O. Helmer, Shani Zev, Ronja Driller, Emily Buhr, Markus Reinbold, Renana Schwartz, Gabriel Foley, Mikael Boden, Daniel Garbe, Gerhard Schenk, Dan Thomas Major, Bernhard Loll, Thomas Brück   +13 more
wiley   +1 more source

The State of the Art in Cartograms

, 2016
Cartograms combine statistical and geographical information in thematic maps, where areas of geographical regions (e.g., countries, states) are scaled in proportion to some statistic (e.g., population, income). Cartograms make it possible to gain insight
Alam, Alam, Beck, Bertin, Bhatt, Biedl, Borkin, Bostock, Brehmer, Buchin, Bustamente, Börner, Cano, Carr, Cleveland, Cleveland, Colizza, Croxton, de Berg, de Berg, Dent, Dent, Donnellan, Dorlimg, Dorling, Dougenik, Eppstein, Evans, Fabrikant, Fabrikant, Funkhouser, Gastner, Gerasimov, Griffin, Guseyn-Zade, Hay, Heer, Hennig, Hennig, Henriques, Howe, Howe, Hunter, Härö, Inoue, Jones, Kadmon, Kasner, Kaspar, Kawaguchi, Kaye, Keim, Keim, Keim, Kocmoud, Krauss, Krygier, Levison, Li, MacEachren, MacEachren, Meulemans, Mislove, North, Nöllenburg, Olson, Pan, Paull, Philbruck, Philip, Raisz, Reveiu, Rittschof, Rittschof, Rittschof, Roth, Roth, Schulz, Selvin, Skiena, Slocum, Snyder, Steven, Sun, Sun, Sun, TAO, Tobler, Tobler, Torguson, Tufte, van Kreveld, Vinogradova, Wake, WARE, Watson, WEHREND, Welzl, Yi, Zhou   +99 more
core   +1 more source

LDAcoop: Integrating non‐linear population dynamics into the analysis of clonogenic growth in vitro

Molecular Oncology, EarlyView.
Limiting dilution assays (LDAs) quantify clonogenic growth by seeding serial dilutions of cells and scoring wells for colony formation. The fraction of negative wells is plotted against cells seeded and analyzed using the non‐linear modeling of LDAcoop.
Nikko Brix, Daniel Samaga, Katharina Gehr, Benedek Dankó, Mohamed Schumann, Guido Drexler, Ahmed Alnatsha, Georg Beyer, Ujjwal Mahajan, Martin Selmansberger, Julia Mayerle, Claus Belka, Horst Zitzelsberger, Kirsten Lauber   +13 more
wiley   +1 more source

Recurrent cancer‐associated ERBB4 mutations are transforming and confer resistance to targeted therapies

Molecular Oncology, EarlyView.
We show that the majority of the 18 analyzed recurrent cancer‐associated ERBB4 mutations are transforming. The most potent mutations are activating, co‐operate with other ERBB receptors, and are sensitive to pan‐ERBB inhibitors. Activating ERBB4 mutations also promote therapy resistance in EGFR‐mutant lung cancer.
Veera K. Ojala, Sini Ahonen, Sara Peltola, Aura Tuohisto‐Kokko, Olaya Esparta, Peppi Suominen, Anne Jokilammi, Iman Farahani, Deepankar Chakroborty, Nikol Dibus, Steffen Boettcher, Tomi T. Airenne, Mark S. Johnson, Lisa D. Eli, Klaus Elenius, Kari J. Kurppa   +15 more
wiley   +1 more source

Analysing the significance of small conformational changes and low occupancy states in serial crystallographic data

FEBS Open Bio, EarlyView.
This protocol paper outlines methods to establish the success of a time‐resolved serial crystallographic experiment, by means of statistical analysis of timepoint data in reciprocal space and models in real space. We show how to amplify the signal from excited states to visualise structural changes in successful experiments.
Jake Hill, Yelyzaveta Pulnova, Elke De Zitter, Helen M. Ginn, Briony A. Yorke   +4 more
wiley   +1 more source