Results 51 to 60 of about 38,115,696 (250)

Partial depletion of plasminogen activator inhibitor‐1 decreases subcutaneous fat cell hypertrophy and liver cholesterol in high‐fat‐fed female mice

FEBS Letters, EarlyView.
Obesity raises blood levels of PAI‐1, a protein linked to metabolic dysfunction‐associated steatotic liver disease in people with obesity. In female mice fed a high‐fat diet, partially lowering PAI‐1 led to smaller subcutaneous fat cells and lower liver cholesterol, without changing body weight or insulin sensitivity.
Claudia E. Ramirez Bustamante, Robert Sharp, Pradip K. Saha, Elizabeth S. Anaya, Elizabeth L. Lieu, Evelyn L. de Groot, Pooja Patel, Mi Jeong Heo, Aaron R. Cox, Kang Ho Kim, Sean M. Hartig   +10 more
wiley   +1 more source

Ligand‐dependent transcriptional heterogeneity in cell cycle gene expression delays G1/S entry

FEBS Letters, EarlyView.
EGF and HRG induce distinct G1/S progression programs in ErbB2‐amplified BT474 breast cancer cells. Despite activating the potent ErbB2–ErbB3 heterodimer, HRG does not accelerate cell‐cycle entry. Instead, EGF promotes earlier restriction‐point passage via ERK–FOS signaling, whereas HRG activates the AKT–MYC axis, driving transcriptional heterogeneity ...
Ririn Rahmala Febri, Ayaka Nagasato‐Ichikawa, Keita Iida, Shuhei Kimura, Akira Imamoto, Mariko Okada   +5 more
wiley   +1 more source

Emerging experimental and computational methods for studying redox‐regulated structural transitions

FEBS Letters, EarlyView.
Redox reactions can reshape proteins and alter how they behave in cells, with important consequences for health and disease. This review explores emerging experimental and computational approaches for discovering these redox‐sensitive protein switches, revealing their structural effects, and predicting their behavior, opening new opportunities to ...
Tasneem Rass, Dana Reichmann, Gábor Erdős   +2 more
wiley   +1 more source

Hand Gesture Interaction with Human-Computer [PDF]

, 2011
Hand gestures are an important modality for human computer interaction. Compared to many existing interfaces, hand gestures have the advantages of being easy to use, natural, and intuitive.
Dr. Dejan Chandra Gope
core  

Synergistic perspectives—How single‐molecule biophysics complement biochemical understanding

FEBS Letters, EarlyView.
In this review, we discuss how ensemble biochemistry and single‐molecule approaches are complementary, outline commonly used single‐molecule techniques, and illustrate their relevance through two representative case studies: chromatin organization by SMC complexes and pathway choice during DNA double‐strand break repair.
Sara De Bragança, Eline L. Jansen, Jorine M. Eeftens   +2 more
wiley   +1 more source

Department of Computer Science newsletter 2020

, 2020
A Newsletter for Friends and Supporters of the Mines Computer Science ...

core  

Initiating and Sustaining Female Networks in Computer Science and IT [PDF]

, 2007
Over the last decade, several networks and communities for women in IT have been initiated. It has been known that specific needs for support exist where members of a minority have difficulties in finding like-minded people in their everyday environment.
Oelinger, Maria, Hinze, Annika
core  

Dynamic primitives for gestural interaction [PDF]

, 2004
We describe the implementation of an interaction technique which allows users to store and retrieve information and computational functionality on different parts of their body.
Brewster, S., Mark D. Dunlop, Leplâtre, Grégory, Day, Robert, Murray-Smith, Roderick, Beale, Russell; id_orcid, Angesleva, J., Mizzaro, Stefano, Dunlop, M, Brewster, S, Marentakis, G., Georgios Marentakis, Parisa Eslambolchilar, Brewster, S.A., Mäntyjärvi, Jani; id_orcid, Hjelt, Kari, Grégory Leplâtre, Simon Holland, Oakley, I., Ian Oakley, Phil Gray, Stephen Brewster, Himberg, Johan, Khammampad, K., Crossan, A., Yeh, T, Roderick Murray-smith, Darrell, T, Eslambolchilar, Parisa, Alistair Edwards, Crestani, Fabio, Steven Strachan, Robert Day, Kartik Khammampad, Strachan, S., Tollmar, Konrad, Mizzaro, S., Fabio, Crestani, Andrew Crossan, Matt, Jone, Lonsdale, P, Edwards, Alistair, Goodman, J., Jones, Matt, Jussi Ängeslevä, Gray, P., Gray, P.D.G., Mark D Dunlop, Dunlop, Mark D., Holland, Simon, Joy Goodman, Murray-Smith, R., Eslambolchilar, P., Nybergh, Kjell, Stephen A. Brewster, Tollmar, Konrad,, Hägglund, Maria,, Koch, Sabine,, Lund University., Scandurra, Isabella,   +59 more
core   +2 more sources

Translophagy—A potential link between autophagy impairment and translational errors

FEBS Letters, EarlyView.
Neurodegenerative diseases are characterised by the accumulation of abnormal proteins and protein aggregates, but their origin often remains unknown. We propose that selective autophagy removes damaged protein‐making machinery, preventing errors during protein synthesis.
Mykola V. Korolchuk, Gailing Ma, Robin Antrobus, Diego Manni, Marco Trevisan‐Herraz, Mustafa Khwaja, Max Brown, Gavin D. Richardson, Masaaki Komatsu, Daniel Erskine, Viktor I. Korolchuk, Tetsushi Kataura   +11 more
wiley   +1 more source

Structural and biochemical analysis of a B12 superbinder

FEBS Letters, EarlyView.
BtuG proteins are vitamin B12 scavengers in Bacteroides thetaiotaomicron, a dominant human gut bacterium. We present crystal structures of three BtuG homologs bound to cobalamin and its precursor cobinamide, revealing picomolar binding affinities, among the highest known for any natural protein.
Jose M. Martinez Felices, Jacob J. Whittaker, Dirk J. Slotboom, Albert Guskov   +3 more
wiley   +1 more source