Results 51 to 60 of about 1,232,339 (197)

Formal verification of safety-critical user interfaces: a space system case study [PDF]

, 2014
Safe operation of safety critical systems depends on appropriate interactions between the human operator and the computer system. Specification of such safety-critical systems is fundamental to enable exhaustive and automated analysis of operator system ...
Alves, Miriam, Campos, J. Creissac, Harrison, M. D., Sousa, Manuel   +3 more
core  

Tau acetylation at K331 has limited impact on tau pathology in vivo

FEBS Letters, EarlyView.
We mapped tau post‐translational modifications in humanized MAPT knock‐in mice and in amyloid‐bearing double knock‐in mice. Acetylation within the repeat domain, particularly around K331, showed modest increases under amyloid pathology. To test functional relevance, we generated MAPTK331Q knock‐in mice.
Shoko Hashimoto, Yukio Matsuba, Mika Takahashi, Takaomi C. Saido   +3 more
wiley   +1 more source

Calpain small subunit homodimerization is robust and calcium‐independent

FEBS Letters, EarlyView.
Calpains dimerize via penta‐EF‐hand (PEF) domains. Using single‐molecule force spectroscopy, we measured the strength and kinetics of PEF–PEF homodimer binding. The interaction is robust, shows a transient conformational step before dissociation, and remains largely insensitive to Ca2+.
Nesha May O. Andoy, Trina Dykstra‐MacPherson, Mathias A. Bell, Peter L. Davies, Ruby May A. Sullan   +4 more
wiley   +1 more source

ICMI 2012 chairs' welcome [PDF]

, 2012
Welcome to Santa Monica and to the 14th edition of the International Conference on Multimodal Interaction, ICMI 2012. ICMI is the premier international forum for multidisciplinary research on multimodal human-human and human-computer interaction ...
Aghajan, Hamid, Bohus, Dan, Cassell, Justine, Epps, Julien, Morency, Louis-Philippe, Nijholt, Anton   +5 more
core   +1 more source

Structural insights into an engineered feruloyl esterase with improved MHET degrading properties

FEBS Letters, EarlyView.
A feruloyl esterase was engineered to mimic key features of MHETase, enhancing the degradation of PET oligomers. Structural and computational analysis reveal how a point mutation stabilizes the active site and reshapes the binding cleft, expading substrate scope.
Panagiota Karampa, Konstantinos Makryniotis, Theofani‐Iosifina Sousani, Evangelos Topakas, Vangelis Daskalakis, Maria Dimarogona   +5 more
wiley   +1 more source

Proceedings of the Third Annual Virginia Tech Center for Human-Computer Interaction Research Experience for Undergraduates (REU) Symposium [PDF]

, 2008
Virginia Tech's Center for Human-Computer Interaction presents the project abstracts for the REU ’08 symposium. The REU (Research Experience for Undergraduates) program provides undergraduate students from various universities with the opportunity to ...
Coordinator, REU
core  

Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system

FEBS Letters, EarlyView.
Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley   +1 more source

Using Augmented Reality as a Medium to Assist Teaching in Higher Education [PDF]

, 2010
In this paper we describe the use of a high-level augmented reality (AR) interface for the construction of collaborative educational applications that can be used in practice to enhance current teaching methods. A combination of multimedia information
Anderson, Eike F., Liarokapis, F.
core  

Valosin‐containing protein counteracts ATP‐driven dissolution of FUS condensates through its ATPase activity in vitro

FEBS Letters, EarlyView.
Biomolecular condensates formed by fused in sarcoma (FUS) are dissolved by high ATP concentrations yet persist in cells. Using a reconstituted system, we demonstrate that valosin‐containing protein (VCP), an AAA+ ATPase, counteracts ATP‐driven dissolution of FUS condensates through its D2 ATPase activity.
Hitomi Kimura, Shin‐ichi Tate, Kyota Yasuda   +2 more
wiley   +1 more source

HUMAN-COMPUTER INTERACTION AS A MULTIDISCIPLINARY FIELD OF SCIENCE

International Journal Of Professional Science, 2017
The article deals with an ongoing problem of human-computer interaction. Human-computer interaction becomes an integral part of many developments, although not always it is given a high priority. The universal use of various computer processing and content creation leads to the fact that a creative activity attached masses of people.
GORELOV A., TERTERYANTS A., KHMELEV G
openaire   +1 more source