Results 21 to 30 of about 422,388 (242)

Integrated genomic and proteomic profiling reveals insights into chemoradiation resistance in cervical cancer

Molecular Oncology, EarlyView.
A comprehensive genomic and proteomic analysis of cervical cancer revealed STK11 and STX3 as a potential biomarkers of chemoradiation resistance. Our study demonstrated EGFR as a therapeutic target, paving the way for precision strategies to overcome treatment failure and the DNA repair pathway as a critical mechanism of resistance.
Janani Sambath, Irene A. George, Srikanth S. Manda, Prasanth Ariyannur, Ekta R. Dhawale, Raja Sekhar Kommu, Rajan Datar, Darshana Patil, Vinita Trivedi, Manisha Singh, Kumar Prabhash, Sewanti Limaye, Richa Chauhan, Prashant Kumar   +13 more
wiley   +1 more source

Improving the Representation and Conversion of Mathematical Formulae by Considering their Textual Context

, 2018
Mathematical formulae represent complex semantic information in a concise form. Especially in Science, Technology, Engineering, and Mathematics, mathematical formulae are crucial to communicate information, e.g., in scientific papers, and to perform ...
Aizawa A., Cajori F., Cohl H. S., Dehaye P., Ginev D., Ion P. D. F., Nghiem M.-Q., Padovani L., Schubotz M., Schubotz M., Schubotz M., Schubotz M., Schubotz M., Schubotz M., Stamerjohanns H., Watt S. M., Youssef A.   +16 more
core   +1 more source

PYCR1 inhibition in bone marrow stromal cells enhances bortezomib sensitivity in multiple myeloma cells by altering their metabolism

Molecular Oncology, EarlyView.
This study investigated how PYCR1 inhibition in bone marrow stromal cells (BMSCs) indirectly affects multiple myeloma (MM) cell metabolism and viability. Culturing MM cells in conditioned medium from PYCR1‐silenced BMSCs impaired oxidative phosphorylation and increased sensitivity to bortezomib.
Inge Oudaert, Lauren van den Broecke, Osman Aksoy, Judith Lind, Sonia Vallet, Arne Van der Vreken, Gamze Ates, Ann Massie, Ken Maes, Kim De Veirman, Elke De Bruyne, Karin Vanderkerken, Klaus Podar, Eline Menu   +13 more
wiley   +1 more source

Affective feedback: an investigation into the role of emotions in the information seeking process [PDF]

, 2008
User feedback is considered to be a critical element in the information seeking process, especially in relation to relevance assessment. Current feedback techniques determine content relevance with respect to the cognitive and situational levels of ...
Arapakis, I., Gray, P.D.G., Jose, J.M.
core   +1 more source

Inhibition of CDK9 enhances AML cell death induced by combined venetoclax and azacitidine

Molecular Oncology, EarlyView.
The CDK9 inhibitor AZD4573 downregulates c‐MYC and MCL‐1 to induce death of cytarabine (AraC)‐resistant AML cells. This enhances VEN + AZA‐induced cell death significantly more than any combination of two of the three drugs in AraC‐resistant AML cells.
Shuangshuang Wu, Jianlei Zhao, Aaban Asfar Azmi, Avanti Gupte, Jenna Thibodeau, Shuang Liu, Jinli Yang, Guan Wang, Holly Edwards, Lisa A. Polin, Juiwanna Kushner, Sijana H. Dzinic, Kathryn White, Julie Boerner, Maik Hüttemann, Jay Yang, Yue Wang, Jeffrey W. Taub, Yubin Ge   +18 more
wiley   +1 more source

Improving information retrieval with dialogue mapping and concept mapping tools : training university teachers to use a new method and integrate information searching exercises into their own instruction [PDF]

, 2007
The Library of Helsinki University of Technology (TKK) has almost 40 years' experience in teaching information retrieval, but has recently revised its training methods. During autumn 2006 the library and the Department of Computer Science and Engineering
Heino, Kirsi, Nevalainen, Jouni, Palmgren, Virpi   +2 more
core  

Managing complexity in a distributed digital library [PDF]

, 1999
As the capabilities of distributed digital libraries increase, managing organizational and software complexity becomes a key issue. How can collections and indexes be updated without impacting queries currently in progress?
Apperley, Mark, Bainbridge, David, Cunningham, Sally Jo, Jones, Steve, McNab, Rodger J., Witten, Ian H.   +5 more
core   +2 more sources

A synthetic benzoxazine dimer derivative targets c‐Myc to inhibit colorectal cancer progression

Molecular Oncology, EarlyView.
Benzoxazine dimer derivatives bind to the bHLH‐LZ region of c‐Myc, disrupting c‐Myc/MAX complexes, which are evaluated from SAR analysis. This increases ubiquitination and reduces cellular c‐Myc. Impairing DNA repair mechanisms is shown through proteomic analysis.
Nicharat Sriratanasak, Bodee Nutho, Worawat Wattanathana, Narumon Phaonakrop, Bunnatut Panasawatwong, Katharina Erlenbach‐Wuensch, Sittiruk Roytrakul, Regine Schneider‐Stock, Pithi Chanvorachote   +8 more
wiley   +1 more source

User experiments with the Eurovision cross-language image retrieval system [PDF]

, 2006
In this paper we present Eurovision, a text-based system for cross-language (CL) image retrieval. The system is evaluated by multilingual users for two search tasks with the system configured in English and five other languages.
Armitage, Ballesteros, Chen, Clough, Clough, Clough, Cox, Dunlop, Elworthy, Flank, Flank, Flank, Gollins, Gonzalo, Goodrum, Grefenstette, Guglielmo, Harmandas, Houghton, Hutchins, Jones, Oard, Oard, Peters, Qu, Reid, Resnik, Robertson, Sanderson, Sanderson, Schäuble, Smeaton, Smeaton, Smeulders, Sormunen, Srihari, Systran Ltd., Voorhees   +37 more
core   +1 more source

Patient‐specific pharmacogenomics demonstrates xCT as predictive therapeutic target in colon cancer with possible implications in tumor connectivity

Molecular Oncology, EarlyView.
This study integrates transcriptomic profiling of matched tumor and healthy tissues from 32 colorectal cancer patients with functional validation in patient‐derived organoids, revealing dysregulated metabolic programs driven by overexpressed xCT (SLC7A11) and SLC3A2, identifying an oncogenic cystine/glutamate transporter signature linked to ...
Marco Strecker, Keren Zohar, Martin Böttcher, Thomas Wartmann, Henry Freudenstein, Maximilian Doelling, Mihailo Andric, Wenjie Shi, Or Kakhlon, Katrin Hippe, Beatrix Jahnke, Dimitrios Mougiakakos, Franziska Baenke, Daniel Stange, Roland S. Croner, Michal Linial, Ulf D. Kahlert   +16 more
wiley   +1 more source