Results 51 to 60 of about 1,076,774 (282)

Respiratory complex I‐mediated NAD+ regeneration regulates cancer cell proliferation through the transcriptional and translational control of p21Cip1 expression by SIRT3 and SIRT7

Molecular Oncology, EarlyView.
NAD+ regeneration by mitochondrial complex I NADH dehydrogenase is important for cancer cell proliferation. Specifically, NAD+ is necessary for the activities of NAD+‐dependent deacetylases SIRT3 and SIRT7, which suppress the expression of p21Cip1 cyclin‐dependent kinase inhibitor, an antiproliferative molecule, at the translational and transcriptional
Masato Higurashi, Kazunori Mori, Hidetsugu Nakagawa, Momoko Uchida, Fumihiro Ishikawa, Motoko Shibanuma   +5 more
wiley   +1 more source

CS 499/699: Logic for Computer Scientists [PDF]

, 2010
Logic is often called the Calculus of Computer Science. Indeed, logic permeates most areas of Computer Science in one way or the other, sometimes more prominently, and sometimes as motivational or formal underpinning.
Hitzler, Pascal
core   +3 more sources

Topics in Programming Languages, a Philosophical Analysis through the case of Prolog [PDF]

, 2018
[EN]Programming languages seldom find proper anchorage in philosophy of logic, language and science. is more, philosophy of language seems to be restricted to natural languages and linguistics, and even philosophy of logic is rarely framed into ...
Homen, Luis Cabrita Pais
core   +2 more sources

Peripheral blood leukocyte signatures as biomarkers in relapsed ovarian cancer patients receiving combined anti‐CD73/anti‐PD‐L1 immunotherapy in arm A of the NSGO‐OV‐UMB1/ENGOT‐OV30 trial

Molecular Oncology, Volume 19, Issue 5, Page 1436-1451, May 2025.
Using mass cytometry, we analyzed serial blood samples from patients with relapsed epithelial ovarian cancer (EOC) treated with oleclumab–durvalumab combination immunotherapy in the NSGO‐OV‐UMB1/ENGOT‐OV30 trial. Our analysis identified potential predictive, monitoring, and response biomarkers detectable through liquid biopsy. These findings facilitate
Luka Tandaric, Annika Auranen, Katrin Kleinmanns, René DePont Christensen, Liv Cecilie Vestrheim Thomsen, Cara Ellen Wogsland, Emmet McCormack, Johanna Mäenpää, Kristine Madsen, Karen Stampe Petersson, Mansoor Raza Mirza, Line Bjørge   +11 more
wiley   +1 more source

Learning programming with an RTS based Serious Game [PDF]

, 2009
International audienceThis paper presents a prototype of a Serious Game that aims to entice gamers to learn computer programming by using a multiplayer real time strategy game (RTS).
Jessel, Jean Pierre, Muratet, Mathieu, Torguet, Patrice   +2 more
core   +3 more sources

Analysis of comprehensive genomic profiling of solid tumors with a novel assay for broad analysis in clinical diagnostics

Molecular Oncology, EarlyView.
In molecular cancer diagnostics, comprehensive genomic profiling (CGP) is going to replace the small NGS panels since it provides all clinically relevant somatic variants as well as genomic biomarkers with clinical value. Here, we compared two CGP assays and demonstrate that the choice for diagnostic implementation will depend on the specific ...
Guy Froyen, Pieter‐Jan Volders, Ellen Geerdens, Severine Berden, Joni Van der Meulen, Aaron De Cock, Stefanie Vermeire, Jacques Van Huysse, Marie de Barsy, Gabriela Beniuga, Wendy W. J. de Leng, Anne M. L. Jansen, Imke Demers, Zeliha Ozgur, Hendrikus Jan Dubbink, Ernst‐Jan M. Speel, Wilfred F. J. van IJcken, Brigitte Maes   +17 more
wiley   +1 more source

Structure of a File Oriented Programming Language, GPLAN-BL-1 [PDF]

, 1975
Modern computer science has developed languages along many distinct paths; three are: Operating System Languages (e.g., OS/JCL), High Level Procedural Languages (e.g., FORTRAN), and High Level Non-Procedural Data Base Languages (e.g., ALPHA, SQUARE ...
Bonczek, R., Whinston, A.B.
core  

Teaching Programming Languages by Experimental and Adversarial Thinking [PDF]

, 2017
We present a new approach to teaching programming language courses. Its essence is to view programming language learning as a natural science activity, where students probe languages experimentally to understand both the normal and extreme behaviors of ...
Fisler, Kathi, Krishnamurthi, Shriram, Pombrio, Justin   +2 more
core   +1 more source

Adverse prognosis gene expression patterns in metastatic castration‐resistant prostate cancer

Molecular Oncology, EarlyView.
We aggregated a cohort of 1012 mCRPC tissue samples from 769 patients and investigated the association of gene expression‐based pathways with clinical outcomes. Loss of AR signaling, high proliferation, and a glycolytic phenotype were independently prognostic for poor outcomes, and an adverse transcriptional feature score incorporating these pathways ...
Marina N. Sharifi, Eric Feng, Nicholas R. Rydzewski, Amy K. Taylor, Jamie M. Sperger, Yue Shi, Kyle T. Helzer, Matthew L. Bootsma, Viridiana Carreno, Alex H. Chang, Luke A. Nunamaker, Grace C. Blitzer, Tianfu Andy Shang, Aishwarya Subramanian, Anders Bjartell, Andreas Josefsson, Pernilla Wikström, Emily Feng, Manish Kohli, Rendong Yang, Scott M. Dehm, Eric J. Small, Rahul Aggarwal, David A. Quigley, Joshua M. Lang, Shuang G. Zhao, Martin Sjöström   +26 more
wiley   +1 more source

Fuzzy Modeling and Natural Language Processing for Panini's Sanskrit Grammar [PDF]

Journal of Computer Science and Engineering, Volume 1, Issue 1, p99-101, May 2010, 2010
Indian languages have long history in World Natural languages. Panini was the first to define Grammar for Sanskrit language with about 4000 rules in fifth century. These rules contain uncertainty information. It is not possible to Computer processing of Sanskrit language with uncertain information.
arxiv