Results 111 to 120 of about 1,420,326 (306)

Data quality implications of scientific software complexity [PDF]

Scientific findings based on computer simulation evoke sceptical responses because their output does not appear to have an objective status comparable to data captured by observation or experiment.
Newman, Julian
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Targeting of PTP4A3 overexpression sensitises HGSOC cells towards chemotherapeutic drugs

Molecular Oncology, EarlyView.
In HGSOC with normal KRAS expression, high PTP4A3 expression regulates autophagy activation. Conversely, in HGSOC with high KRAS expression, KRAS dictates autophagy control, and PTP4A3 is not required. When high PTP4A3 expression is inhibited, HGSOC cells are preferentially sensitised towards DNA‐damaging agents.
Ana López‐Garza, David James, Emma Creagh, James T. Murray   +3 more
wiley   +1 more source

Unifying an Introduction to Artificial Intelligence Course through Machine Learning Laboratory Experiences

, 2005
This paper presents work on a collaborative project funded by the National Science Foundation that incorporates machine learning as a unifying theme to teach fundamental concepts typically covered in the introductory Artificial Intelligence courses.
Coleman, Susan, Georgiopoulos, Michael, Markov, Zdravko, Neller, Todd W., Russell, Ingrid   +4 more
core  

Olaparib synergy screen reveals Exemestane induces replication stress in triple‐negative breast cancer

Molecular Oncology, EarlyView.
Screening 166 FDA‐approved anticancer drugs identifies the aromatase inhibitor Exemestane as a synergistic partner of PARP inhibitor Olaparib in BRCA‐proficient triple‐negative breast cancer. Exemestane induces ROS‐mediated replication stress, enhancing DNA damage and apoptosis alongside Olaparib.
Nur Aininie Yusoh, Liping Su, Suet Lin Chia, Xiaohe Tian, Haslina Ahmad, Martin R. Gill   +5 more
wiley   +1 more source

RKIP overexpression reduces lung adenocarcinoma aggressiveness and sensitizes cells to EGFR‐targeted therapies

Molecular Oncology, EarlyView.
RKIP, a metastasis suppressor protein, modulates key oncogenic pathways in lung adenocarcinoma. In silico analyses linked low RKIP expression to poor survival. Functional studies revealed RKIP overexpression reduces tumor aggressiveness and enhances sensitivity to EGFR‐targeted therapies, while its loss promotes resistance.
Ana Raquel‐Cunha, Joana Pinheiro, Rui F. Marques, Patrícia Fontão, Diana Cardoso‐Carneiro, Adriana Mendes, Izabela N. F. Gomes, Ana Carolina Laus, Renato J. da Silva‐Oliveira, Rui Manuel Reis, Olga Martinho   +10 more
wiley   +1 more source

Notes from the 12th Conference on Software Engineering Education and Training (CSEET) and 13th SIGCSE Technical Symposium on Computer Science Education (CSE)

, 1999
Richard Conn
openalex   +1 more source

3rd Workshop for Young Scientists in Computer Science & Software Engineering [PDF]

, 2021
Arnold Kiv, Сергій Олексійович Семеріков, Vladimir Soloviev, Andrii M. Striuk   +3 more
openalex   +1 more source

Single‐cell transcriptomics redefines focal neuroendocrine differentiation as a distinct prostate cancer pathology

Molecular Oncology, EarlyView.
Single‐cell transcriptomics of prostate cancer patient‐derived xenografts reveals distinct features of neuroendocrine (NE) subtypes. Tumours with focal NE differentiation (NED) share transcriptional programmes with adenocarcinoma, differing from large and small cell neuroendocrine prostate cancer (NEPC). Our work defines the molecular landscape of NEPC,
Rosalia Quezada Urban, Shivakumar Keerthikumar, Ashlee Clark, Hong Wang, Belinda Phipson, Andrew Bakshi, Andrew Ryan, Heather Thorne, Renea A. Taylor, Mitchell G. Lawrence, Gail P. Risbridger, Roxanne Toivanen, David L. Goode   +12 more
wiley   +1 more source

Research on Basic Programming System of Computer Science Mobile APP Software Engineering [PDF]

, 2021
Haoran Wang
openalex   +1 more source

SET for success : the supply of people with science, technology, engineering and mathematics skills : the report of Sir Gareth Roberts' review [PDF]

In March 2001, Sir Gareth Roberts was asked by the Chancellor of the Exchequer and the Secretaries of State at the Department of Trade and Industry and at the Department for Education and Skills to undertake a review into the supply of science and ...
Roberts, Gareth Gwyn
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