Results 71 to 80 of about 216,331 (260)
Interpreting the effects of DNA polymerase variants at the structural level
Molecular Oncology, EarlyView.Using MAVISp and molecular dynamics simulations, we analyzed over 60 000 missense variants in POLE and POLD1 from ClinVar, COSMIC, cBioPortal, and saturation mutagenesis. Identified mechanistic indicators, including stability, binding, and long‐range, enable structural interpretation, providing ACMG‐like evidence for possible reclassification of VUS ...
Matteo Arnaudi +7 more
wiley +1 more source
Molecular Oncology, EarlyView.Ixazomib inhibits proteasome‐mediated degradation of topoisomerase I induced by irinotecan, thereby restoring drug sensitivity and promoting tumor cell death in colorectal cancer. Irinotecan, a topoisomerase I (topoI) inhibitor, is widely used for colorectal cancer, but resistance remains a major clinical challenge.
Yuho Ebata +10 more
wiley +1 more source
Small scale software engineering
, 1981 This thesis was submitted for the degree of Doctor of Philosophy and awarded by Brunel University.In computing, the Software Crisis has arisen because software projects cannot meet their planned timescales, functional capabilities, reliability levels and
Witty, Robert W
core
Integration Strategies for Computational Science & Engineering Software
, 2009 Second International Workshop on Software Engineering for Computational Science and Engineering May 23, 2009 Abstract: In order to make significant progress in solving challenging problems in Computational Science & Engineering (CS&E), we need to integrate a large amount of software written by different groups of experts.
openaire +1 more source
Molecular Oncology, EarlyView.Radiotherapy (RT) response depends on the DNA repair capacity of tumor and host cells. We show that circulating tumor cell (CTC) counts and apoptosis rates before and after RT predict treatment response and outcome, which can be accessed via easily accessible liquid biopsy approaches. Created in BioRender. Wikman, H.
Yvonne Goy +10 more
wiley +1 more source
Software Engineering and Computer Science website [PDF]
, 2003 onlyThe Software Engineering and Computer Science Website was designed in response to the problems of the Department. Since, there is no current website the teacher’s post their announcement on the bulletin board were there is a possibility that the ...
Fernandez, Catherine +4 more
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Informatics Related Branch's Curriculum and Role of Project Management
, 2013 Misra, Sanjay/0000-0002-3556-9331The most important goal of the software industry is to produce successful product. During the process of production several times the product fails due to lack of proper management.
Akman, Kamil İbrahim +5 more
core +1 more source
Molecular Oncology, EarlyView.A urine‐based digital PCR assay targeting two hotspot TERT promoter variants detected bladder cancer with high sensitivity and no false positives in this case–control cohort. The streamlined AbsoluteQ workflow outperformed Sanger sequencing and supports non‐invasive molecular testing for bladder cancer detection.
Anna Nykel +12 more
wiley +1 more source
Market-Driven Software Project Through Agility: Requirements Engineering Perspective
, 2009 Mishra, Deepti/0000-0001-5144-3811; Mishra, Alok/0000-0003-1275-2050Time-to-market and insufficient initial requirements are two major challenges that make requirement engineering for market-driven software projects different from bespoke software ...
Mıshra, Deepti +3 more
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Molecular Oncology, EarlyView.Combining osimertinib with the STING agonist ADU‐S100 activates innate and adaptive immunity to overcome the non‐inflamed microenvironment of Egfr‐mutant lung cancer. This combination increases NK and CD8+ T‐cell infiltration, associated with activation of the STING‐IRF3 pathway and local immunogenic cell death.
Jun Nishimura +19 more
wiley +1 more source