Results 51 to 60 of about 216,331 (260)
Molecular Oncology, EarlyView.Cytarabine is a key therapy for acute myeloid leukaemia (AML), but its efficacy is limited by the dNTPase SAMHD1, which hydrolyses its active metabolite. Screening nucleotide biosynthesis inhibitors revealed that IMPDH inhibitors selectively sensitise SAMHD1‐proficient AML cells to cytarabine.
Miriam Yagüe‐Capilla +9 more
wiley +1 more source
The T experiments: errors in scientific software [PDF]
, 1997 Extensive tests showed that many software codes widely used in science and engineering are not as accurate as we would like to think. It is argued that better software engineering practices would help solve this problem, but realizing that the problem ...
Hatton, Leslie, L. Hatton
core +1 more source
A survey of the relevance of computer science and software engineering education [PDF]
Proceedings 11th Conference on Software Engineering Education, 2002 We describe a study of 168 software professionals to determine how relevant their education has been to their careers. Starting with a list of 57 topics, we asked the participants to indicate how much they learned in university, how much they know now, how useful the material has been and whether they would like to learn more.
openaire +1 more source
Molecular Oncology, EarlyView.We have established a humanized orthotopic patient‐derived xenograft (Hu‐oPDX) mouse model of high‐grade serous ovarian cancer (HGSOC) that recapitulates human tumor–immune interactions. Using combined anti‐PD‐L1/anti‐CD73 immunotherapy, we demonstrate the model's improved biological relevance and enhanced translational value for preclinical ...
Luka Tandaric +10 more
wiley +1 more source
CCDC80 suppresses high‐grade serous ovarian cancer migration via negative regulation of B7‐H3
Molecular Oncology, EarlyView.PAX8 is a lineage‐specific master regulator of transcription in high‐grade serous ovarian cancer (HGSC) progression. We show for the first time that PAX8 facilitates proliferation and metastasis by repressing the cell autonomous tumor suppressor CCDC80 and inducing B7‐H3 expression.
Aya Saleh +12 more
wiley +1 more source
Towards verifying correctness of wireless sensor network applications using Insense and Spin
, 2011 The design and implementation of wireless sensor network applications often require domain experts, who may lack expertise in software engineering, to produce resource-constrained, concurrent, real-time software without the support of high-level software
Balasubramaniam, Dharini +6 more
core +1 more source
Innovations in Computing Sciences and Software Engineering [PDF]
, 2010 Innovations in Computing Sciences and Software Engineering includes a set of rigorously reviewed world-class manuscripts addressing and detailing state-of-the-art research projects in the areas of Computer Science, Software Engineering, Computer Engineering, and Systems Engineering and Sciences.
openaire +1 more source
E2A selectively regulates TGF‐β–induced apoptosis in KRAS‐mutant non‐small cell lung cancer
Molecular Oncology, EarlyView.Ability to induce apoptosis by TGF‐β is frequently lost in advanced lung adenocarcinoma despite intact TGF‐β signaling. We identify E2A as a mutant KRAS–dependent mediator of resistance to TGF‐β–induced apoptosis. TGF‐β induces E2A via SMAD3 in mutant KRAS cells, and E2A silencing restores apoptosis and enhances radiation response in cell lines ...
Sergei Chuikov +3 more
wiley +1 more source
Using generative programming to visualise hypercode in complex and dynamic systems
, 2011 The research presented here takes place in the context of the EC Funded ArchWare project which focuses on innovative architecture-centric languages, frameworks and tools for engineering evolvable software systems.
Balasubramaniam, Dharini +4 more
core
Ttirkiye'de Bili§im Mtihendisligi Egitimi ve Yazilim Sektoriintin Beklentileri
, 2018 In this study, using the ÖSYM data, the number of intakes in Informatics Engineering programs in Turkey, accreditation data and the medium of instruction of the program are summarized for the years 2016 and 2017.
Mishra,A. +7 more
core +1 more source