Results 31 to 40 of about 34,521,907 (248)

Peripheral lysosomes recruit PLEKHG3 to focal adhesions and restrain protrusion dynamics

FEBS Letters, EarlyView.
Proximity‐dependent labeling at the LAMTOR complex revealed the Rho GEF PLEKHG3 as a lysosome‐proximal protein directing the study toward the influence of lysosome positioning on actin dynamics and cell motility. We show that PLEKHG3 colocalizes with lysosomes at focal adhesion sites and observe that forced peripheral dispersion of lysosomes hinders ...
Rainer Ettelt, Ana‐Maria Sandru, Georg Vucak, Sebastian Didusch, Biljana Riemelmoser, Karin Ehrenreiter, Markus Hartl, Lukas A. Huber, Manuela Baccarini   +8 more
wiley   +1 more source

Sustainable Software Engineering: Curriculum Development Based on Acm/Ieee Guidelines

, 2021
Climate change risk and environmental degradation are the most critical issues of our society. Our technology-influenced daily lifestyle involves many types of software and apps which are used by society at large, and their use is increasing more than ...
Mishra,A., Mıshra, Deepti, Mishra,D., Mıshra, Alok   +3 more
core   +1 more source

Partial depletion of plasminogen activator inhibitor‐1 decreases subcutaneous fat cell hypertrophy and liver cholesterol in high‐fat‐fed female mice

FEBS Letters, EarlyView.
Obesity raises blood levels of PAI‐1, a protein linked to metabolic dysfunction‐associated steatotic liver disease in people with obesity. In female mice fed a high‐fat diet, partially lowering PAI‐1 led to smaller subcutaneous fat cells and lower liver cholesterol, without changing body weight or insulin sensitivity.
Claudia E. Ramirez Bustamante, Robert Sharp, Pradip K. Saha, Elizabeth S. Anaya, Elizabeth L. Lieu, Evelyn L. de Groot, Pooja Patel, Mi Jeong Heo, Aaron R. Cox, Kang Ho Kim, Sean M. Hartig   +10 more
wiley   +1 more source

Ligand‐dependent transcriptional heterogeneity in cell cycle gene expression delays G1/S entry

FEBS Letters, EarlyView.
EGF and HRG induce distinct G1/S progression programs in ErbB2‐amplified BT474 breast cancer cells. Despite activating the potent ErbB2–ErbB3 heterodimer, HRG does not accelerate cell‐cycle entry. Instead, EGF promotes earlier restriction‐point passage via ERK–FOS signaling, whereas HRG activates the AKT–MYC axis, driving transcriptional heterogeneity ...
Ririn Rahmala Febri, Ayaka Nagasato‐Ichikawa, Keita Iida, Shuhei Kimura, Akira Imamoto, Mariko Okada   +5 more
wiley   +1 more source

Engineering for a science-centric experimentation platform [PDF]

, 2020
Netflix is an internet entertainment service that routinely employs experimentation to guide strategy around product innovations. As Netflix grew, it had the opportunity to explore increasingly specialized improvements to its service, which generated ...
Gerostathopoulos, Ilias; id_orcid, Ilias Gerostathopoulos, McFarland, Colin,, Mao, Tobias, Wong, Jeffrey,, Diamantopoulos, Nikos, Matthew Wardrop, Mattos, David Issa, Mao, Tobias,, Wardrop, Matthew, Gerostathopoulos, Ilias,, Issa Mattos, David,, Gerostathopoulos, Ilias, David Issa Mattos, Diamantopoulos, Nikos,, Issa Mattos, David, Nikos Diamantopoulos, McFarland, Colin, Jeffrey Wong, Colin McFarland, Wong, Jeffrey, Tobias Mao, Wardrop, Matthew,   +22 more
core   +2 more sources

Translophagy—A potential link between autophagy impairment and translational errors

FEBS Letters, EarlyView.
Neurodegenerative diseases are characterised by the accumulation of abnormal proteins and protein aggregates, but their origin often remains unknown. We propose that selective autophagy removes damaged protein‐making machinery, preventing errors during protein synthesis.
Mykola V. Korolchuk, Gailing Ma, Robin Antrobus, Diego Manni, Marco Trevisan‐Herraz, Mustafa Khwaja, Max Brown, Gavin D. Richardson, Masaaki Komatsu, Daniel Erskine, Viktor I. Korolchuk, Tetsushi Kataura   +11 more
wiley   +1 more source

AS-818-16 Resolution on Department Name Change: Computer Science to Computer Science and Software Engineering [PDF]

, 2016
Changes the department name to Computer Science and Software ...
The Department of Computer Science,
core  

Structural and biochemical analysis of a B12 superbinder

FEBS Letters, EarlyView.
BtuG proteins are vitamin B12 scavengers in Bacteroides thetaiotaomicron, a dominant human gut bacterium. We present crystal structures of three BtuG homologs bound to cobalamin and its precursor cobinamide, revealing picomolar binding affinities, among the highest known for any natural protein.
Jose M. Martinez Felices, Jacob J. Whittaker, Dirk J. Slotboom, Albert Guskov   +3 more
wiley   +1 more source

Structures of mycobacterial 3‐methylcrotonyl‐CoA carboxylase reveal carrier‐domain translocation between catalytic sites

FEBS Letters, EarlyView.
Mycobacterial 3‐methylcrotonyl‐CoA carboxylase uses a mobile biotin‐carrying domain to shuttle a carboxyl group between two catalytic sites, enabling carboxylation of 3‐methylcrotonyl‐CoA during leucine breakdown. Cryo‐electron microscopy captures the carrier at both sites and reveals an inward loop movement that may prevent futile rebinding to the ...
Ajit Yadav, Bogdan I. Florea, Sebastian Geibel   +2 more
wiley   +1 more source

Software Engineering Practices and Challenges in Bangladesh: A Preliminary Survey [PDF]

, 2017
The software development industry of Bangladesh seems to be a promising destination for business process outsourcing. But the question is, are the practitioners following proper software engineering techniques, or, what are the challenges they are facing?
Rahim, Md Shamsur; Department of Computer Science, American International University-Bangladesh, Dhaka, Bangladesh., Chowdhury, AZM Ehtesham; Department of Computer Science, American International University-Bangladesh, Dhaka, Bangladesh., Hasan, Md. Hasibul; Department of Computer Science, American International University-Bangladesh, Dhaka, Bangladesh., Das, Shovra; Department of Computer Science, American International University-Bangladesh, Dhaka, Bangladesh.   +3 more
core