Results 101 to 110 of about 5,026,987 (343)

Decoding the dual role of autophagy in cancer through transcriptional and epigenetic regulation

FEBS Letters, EarlyView.
Transcriptional and epigenetic regulation controls autophagy, which exerts context‐dependent effects on cancer: Autophagy suppresses tumorigenesis by maintaining cellular homeostasis or promotes tumor progression by supporting survival under stress. In this “In a Nutshell” article, we explore the intricate mechanisms of the dual function of autophagy ...
Young Suk Yu, Ik Soo Kim, Sung Hee Baek
wiley   +1 more source

An investigation into the use of e-assessment to support student learning [PDF]

, 2009
Interactive computer-marked assessment has been incorporated into a range of science courses at the UK Open University. Different question types have been used, but all allow students multiple attempts so as to enable them to act on the feedback provided.
Jordan, Sally
core  

Computer, Computer Science, and Computational Thinking: Relationship between the Three Concepts

Human Behavior and Emerging Technologies
Digital computers were invented in the 1940s. They are sophisticated and versatile machines whose functioning is grounded in elaborate theory. Advances in theory and the availability of computers helped computer science to develop as an academic ...
Pinaki Chakraborty
doaj   +1 more source

Autophagy in cancer and protein conformational disorders

FEBS Letters, EarlyView.
Autophagy plays a crucial role in numerous biological processes, including protein and organelle quality control, development, immunity, and metabolism. Hence, dysregulation or mutations in autophagy‐related genes have been implicated in a wide range of human diseases.
Sergio Attanasio
wiley   +1 more source

Steiner t-designs for large t

, 2008
One of the most central and long-standing open questions in combinatorial design theory concerns the existence of Steiner t-designs for large values of t. Although in his classical 1987 paper, L.
A. Betten, A. Delandtsheer, D. Gorenstein, D. Livingstone, D. Pei, D.G. Higman, D.K. Ray-Chaudhuri, D.R. Hughes, D.R. Stinson, D.R. Stinson, F. Buekenhout, F. Buekenhout, G.-C. Rota, H. Lüneburg, H. Wielandt, J. Saxl, J. Tits, J.D. Dixon, J.H. Conway, L. Teirlinck, M. Hall Jr., M. Huber, M. Huber, M. Huber, M. Huber, M.W. Liebeck, M.W. Liebeck, N.D. Tuan, P. Dembowski, P. Kaski, P.J. Cameron, P.J. Cameron, P.J. Cameron, P.J. Cameron, P.J. Cameron, R.A. Fisher, R.E. Block, T.. Beth, W.C. Huffman, W.M. Kantor, W.M. Kantor   +40 more
core   +2 more sources

A stepwise emergence of evolution in the RNA world

FEBS Letters, EarlyView.
How did biological evolution emerge from chemical reactions? This perspective proposes a gradual scenario of self‐organization among RNA molecules, where catalytic feedback on random mixtures plays the central role. Short oligomers cross‐ligate, and self‐assembly enables heritable variations. An event of template‐externalization marks the transition to
Philippe Nghe
wiley   +1 more source

Algebraic conversions [PDF]

, 2001
An examination of the pure algebraic properties of computational type conversion leads to a new generalizations of the concept of a homomorphism for which the term conversion seems appropriate. While an homomorphism is a mapping that respects the value
Mills, Bruce
core  

HCBiLSTM: A hybrid model for predicting heart disease using CNN and BiLSTM algorithms

Measurement: Sensors, 2023
In human existence, healthcare is an inevitable obligation. Heart disease is a broad term that encompasses a variety of illnesses that affect the heart & veins.
Prashant Kumar Shrivastava, Mayank Sharma, Pooja sharma, Avenash Kumar   +3 more
doaj  

B cell mechanobiology in health and disease: emerging techniques and insights into therapeutic responses

FEBS Letters, EarlyView.
B cells sense external mechanical forces and convert them into biochemical signals through mechanotransduction. Understanding how malignant B cells respond to physical stimuli represents a groundbreaking area of research. This review examines the key mechano‐related molecules and pathways in B lymphocytes, highlights the most relevant techniques to ...
Marta Sampietro, Marco Cellani, Cristina Scielzo   +2 more
wiley   +1 more source

The thioredoxin‐like and one glutaredoxin domain are required to rescue the iron‐starvation phenotype of HeLa GLRX3 knock out cells

FEBS Letters, EarlyView.
Glutaredoxin (Grx) 3 proteins contain a thioredoxin domain and one to three class II Grx domains. These proteins play a crucial role in iron homeostasis in eukaryotic cells. In human Grx3, at least one of the two Grx domains, together with the thioredoxin domain, is essential for its function in iron metabolism.
Laura Magdalena Jordt, Manuela Gellert, Finja Zelms, Sander Bekeschus, Christopher Horst Lillig   +4 more
wiley   +1 more source