Genomics‐led approach to drug testing in models of undifferentiated pleomorphic sarcoma
Molecular Oncology, EarlyView.GA text Genomic data from undifferentiated pleomorphic sarcoma patients and preclinical models were used to inform a targeted drug screen. Selected compounds were tested in 2D and 3D cultures of UPS cell lines. A combination of trametinib and infigratinib was synergistic in the majority of UPS cell lines tested, which was further confirmed in an ex ...
Piotr J. Manasterski +19 more
wiley +1 more source
All Computer Science Papers @ arXiv.org -- A High-Quality Gold Standard for Citation-based Tasks
, 2019 Michael Färber +2 more
openalex +4 more sources
Retraction Note: Enhanced human activity recognition in medical emergencies using a hybrid deep CNN and bi-directional LSTM model with wearable sensors. [PDF]
Sci RepChandramouli NA +7 more
europepmc +1 more source
Computer and Information Science, Vol. 1, No. 2, May 2008, all in one file
, 2008 Editor CIS
openalex +2 more sources
A nucleotide‐independent, pan‐RAS‐targeted DARPin elicits anti‐tumor activity in a multimodal manner
Molecular Oncology, EarlyView.We report a Designed Ankyrin Repeat Protein that binds and inhibits RAS proteins, which serve as central cell signaling hubs and are essential for the progression of many cancers. Its unique feature is that it does not discriminate between different RAS isoforms or mutations and is capable of binding to RAS in both its active (GTP‐bound) and inactive ...
Jonas N. Kapp +13 more
wiley +1 more source
RETRACTED: Hasanin et al. Exploration of Despair Eccentricities Based on Scale Metrics with Feature Sampling Using a Deep Learning Algorithm. <i>Diagnostics</i> 2022, <i>12</i>, 2844. [PDF]
Diagnostics (Basel)Hasanin T +5 more
europepmc +1 more source
Computer and Information Science, Vol. 2, No. 2, May 2009, all in one file, Part A
, 2009 Editor CIS
openalex +1 more source
Unraveling LINE‐1 retrotransposition in head and neck squamous cell carcinoma
Molecular Oncology, EarlyView.The novel RetroTest method allows the detection of L1 activation in clinical samples with low DNA input, providing global L1 activity and the identification of the L1 source element. We applied RetroTest to a real‐world cohort of HNSCC patients where we reported an early L1 activation, with more than 60% of T1 patients showing L1 activity.
Jenifer Brea‐Iglesias +12 more
wiley +1 more source
Correction: Transformer-inspired training principles based breast cancer prediction: combining EfficientNetB0 and ResNet50. [PDF]
Sci RepShahzad T +3 more
europepmc +1 more source
Molecular Oncology, EarlyView.Overexpression of CHRDL2 in colon cancer cells makes them more stem‐like and resistant to chemo‐ and radiotherapy. CHRDL2‐high cells have upregulation of the WNT pathway, genes involved in the DNA damage response (DDR) pathway and epithelial‐to‐mesenchymal transition (EMT). This leads to quicker repair of damaged DNA and more cell migration.
Eloise Clarkson, Annabelle Lewis
wiley +1 more source