Results 211 to 220 of about 2,254,385 (285)

Aberrant expression of nuclear prothymosin α contributes to epithelial‐mesenchymal transition in lung cancer

Molecular Oncology, EarlyView.
Nuclear prothymosin α inhibits epithelial‐mesenchymal transition (EMT) in lung cancer by increasing Smad7 acetylation and competing with Smad2 for binding to SNAI1, TWIST1, and ZEB1 promoters. In early‐stage cancer, ProT suppresses TGF‐β‐induced EMT, while its loss in the nucleus in late‐stage cancer leads to enhanced EMT and poor prognosis.
Liyun Chen, Chung‐Teng Wang, Jia‐Ming Chang, Ai‐Li Shiau, Gia‐Shing Shieh, Yau‐Lin Tseng, Yi‐Ting Yen, Tang‐Hsiu Huang, Li‐Hsin Cheng, Yu‐Chih Wu, Chao‐Liang Wu, Bing‐Hua Su, Pensee Wu   +12 more
wiley   +1 more source

Determination of ADP/ATP translocase isoform ratios in malignancy and cellular senescence

Molecular Oncology, EarlyView.
The individual functions of three isoforms exchanging ADP and ATP (ADP/ATP translocases; ANTs) on the mitochondrial membrane remain unclear. We developed a method for quantitatively differentiating highly similar human ANT1, ANT2, and ANT3 using parallel reaction monitoring. This method allowed us to assess changes in translocase levels during cellular
Zuzana Liblova, Dominika Maurencova, Barbora Salovska, Marek Kratky, Tomas Mracek, Zuzana Korandova, Alena Pecinova, Pavla Vasicova, David Rysanek, Ladislav Andera, Ivo Fabrik, Rudolf Kupcik, Pavel Kashmel, Pinky Sultana, Vojtech Tambor, Jiri Bartek, Josef Novak, Marie Vajrychova, Zdenek Hodny   +18 more
wiley   +1 more source

Early metastasis is characterized by Gr1+ cell dysregulation and is inhibited by immunomodulatory nanoparticles

Molecular Oncology, EarlyView.
Breast cancer metastasis is associated with myeloid cell dysregulation and the lung‐specific accumulation of tumor‐supportive Gr1+ cells. Gr1+ cells support metastasis, in part, through a CHI3L1‐mediated mechanism, which can be targeted and inhibited with cargo‐free, polymeric nanoparticles.
Jeffrey A. Ma, Sophia M. Orbach, Kate V. Griffin, Kathryn Kang, Yining Zhang, Rebecca S. Pereles, Ian A. Schrack, Guillermo Escalona, Jacqueline S. Jeruss, Lonnie D. Shea   +9 more
wiley   +1 more source

Detecting homologous recombination deficiency for breast cancer through integrative analysis of genomic data

Molecular Oncology, EarlyView.
This study develops a semi‐supervised classifier integrating multi‐genomic data (1404 training/5893 validation samples) to improve homologous recombination deficiency (HRD) detection in breast cancer. Our method demonstrates prognostic value and predicts chemotherapy/PARP inhibitor sensitivity in HRD+ tumours.
Rong Zhu, Katherine Eason, Suet‐Feung Chin, Paul A. W. Edwards, Raquel Manzano Garcia, Richard Moulange, Jia Wern Pan, Soo Hwang Teo, Sach Mukherjee, Maurizio Callari, Carlos Caldas, Stephen‐John Sammut, Oscar M. Rueda   +12 more
wiley   +1 more source

Preparing K-8 Teachers to Teach and Infuse Computer Science Across All Subjects

Angela S. Williams-Nash, Sumi Hagiwara, Katherine G. Herbert, Thomas J. Marlowe, Rebecca A. Goldstein, Vaibhav Anu   +5 more
openalex   +1 more source

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Industry’s push for computer science education: Is computer science really for all?

Policy Futures in Education, 2022
Recent research on Computer Science (CS) has largely found that inequities in access persist. In 2016, President Obama announced the Computer Science for All initiative, recognizing that CS is a “new” basic skill in K-12 schools and over US$4 billion was pledged to Computer Science education (CSEd) initiatives.
Stefanie L Marshall, Ain A Grooms
openaire   +2 more sources

Pedagogy that Supports Computer Science for All

ACM Transactions on Computing Education, 2019
The Computer Science (CS) for All movement has taken hold of the United States and CS education is rapidly expanding across nations throughout the world. Yet, as curricula and professional development opportunities are developed, key questions remain about what “works” for engaging youth in CS education, especially those who are historically ...
Jean J. Ryoo
openaire   +3 more sources

"For all" in "computer science for all"

Communications of the ACM, 2016
Seeking to expand inclusiveness in computer science education.
Maya Israel, Richard E. Ladner
openaire   +3 more sources

Ten Lessons for Computer Science for All

ACM Inroads, 2016
U S President Barack Obama’s agenda of Computer Science for All [26] brings an incredible opportunity for broadening participation in computing. Yet, along with this opportunity come risks and possible unintended consequences.
Jane Margolis, Joanna Goode
openaire   +3 more sources

Towards the synthetic all-optical computer: science fiction or reality?

J. Mater. Chem., 2004
The global race for the optically integrated photonic chip is driven by the prospective that miniaturization of optical devices and enhanced chip functionality may revolutionize the manufacture of optical circuits, and the futuristic dream of the all-optical computer may come true.
Geoffrey A. Ozin, San Ming Yang, Hernán Míguez, Nicolas Tétreault, Benjamin Hatton, E. Vekris, Vladimir Kitaev, Sean Wong, André C. Arsenault, Sébastien Fournier-Bidoz   +9 more
openaire   +3 more sources