Results 51 to 60 of about 308,543 (305)

Patient therapy outcome modeling in cancer organoids is improved by cancer‐associated fibroblasts and organoid assembly convolution

Molecular Oncology, EarlyView.
Patient‐derived organoids (PDOs) from pancreatic, colorectal, and gastric cancers were used to evaluate standard and experimental therapies. Incorporating cancer‐associated fibroblasts (CAFs) into organoid cultures improved patient therapy outcome prediction.
Marcin Grochowski, Liudmyla Dolinchuk, Michał Jerzak, Albert Gandurski, Tomasz Grochowski, Weronika Wojtyś, Maciej Zadrożny, Wojciech Kaźmierczak, Małgorzata Lenarcik, Marta Matejak‐Górska, Radosław Samsel, Tomasz Olesiński, Dawid Walerych   +12 more
wiley   +1 more source

Concepts of Proof in Mathematics, Philosophy, and Computer Science

, 2016
A proof is a successful demonstration that a conclusion necessarily follows by logical reasoning from axioms which are considered evident for the given context and agreed upon by the community.
Schuster, Peter Michael, Dieter Probst, Peter Schuster, Probst, Dieter   +3 more
core   +2 more sources

Single‐molecule DNA flow‐stretch assays for high‐throughput DNA–protein interaction studies

FEBS Open Bio, EarlyView.
We describe an optimised single‐molecule DNA flow‐stretch assay that visualises DNA–protein interactions in real time. Linear DNA fragments are tethered to a surface and stretched by buffer flow for fluorescence imaging. Using λ and φX174 DNA, this protocol enhances reproducibility and accessibility, providing a versatile approach for studying diverse ...
Ayush Kumar Ganguli, Mohammad Nour Alsamsam, Ugnė Bagdonaitė, Van Truc Vu, Chun‐Jen Huang, Polina Kuzhir, Mindaugas Zaremba, Aurimas Kopūstas, Marijonas Tutkus   +8 more
wiley   +1 more source

Mathematical Logic in Computer Science

CoRR, 2018
The article retraces major events and milestones in the mutual influences between mathematical logic and computer science since the 1950s.
openaire   +3 more sources

Chameleon sequences reveal structural effects in proteins representing micelle‐like distribution of hydrophobicity

FEBS Open Bio, EarlyView.
Amino acids sequence of two different proteins with the same sequence (chameleon sequence—black boxes) represent in 3D structure of the proteins different secondary structures: HHHH—helical and BBB—Beta‐structural. The chains folded in water environment adopt different III‐order structures in which the chameleon fragments appear to adopt similar status
Irena Roterman, Katarzyna Stapor, Leszek Konieczny, Krzysztof Gądek, Piotr Nowakowski   +4 more
wiley   +1 more source

Proof and Computation. Digitization in Mathematics, Computer Science, and Philosophy

, 2018
This book is for graduate students and researchers, introducing modern foundational research in mathematics, computer science, and philosophy from an interdisciplinary point of view.
Crosilla, Laura, Ishihara, Hajime, Miyamoto, Kenji, Wainer, Stanley S., Wiesnet, Franziskus, Berger, Josef, Sato, Masahiko, Schuster, Peter, Mainzer, Klau, Swindland, Gregor, Schwichtenberg, Helmut   +10 more
core   +1 more source

Approximating Maximum Edge 2-Coloring by Normalizing Graphs [PDF]

Discrete Mathematics & Theoretical Computer Science
In a simple, undirected graph G, an edge 2-coloring is a coloring of the edges such that no vertex is incident to edges with more than 2 distinct colors.
Tobias Mömke, Alexandru Popa, Aida Roshany-Tabrizi, Michael Ruderer, Roland Vincze   +4 more
doaj   +1 more source

Analysing the significance of small conformational changes and low occupancy states in serial crystallographic data

FEBS Open Bio, EarlyView.
This protocol paper outlines methods to establish the success of a time‐resolved serial crystallographic experiment, by means of statistical analysis of timepoint data in reciprocal space and models in real space. We show how to amplify the signal from excited states to visualise structural changes in successful experiments.
Jake Hill, Yelyzaveta Pulnova, Elke De Zitter, Helen M. Ginn, Briony A. Yorke   +4 more
wiley   +1 more source

The skills required for transition to university and study in biological sciences: A student perspective

FEBS Open Bio, EarlyView.
Bioscience students were asked for their opinions on the value and teaching of skills. 204 responded that teamwork, time management and study skills are necessary to reach University, that scientific writing, research, laboratory and presentation skills are taught effectively during their studies, while other skills are gained inherently through study ...
Janella Borrell, Susan Crennell
wiley   +1 more source

Applications of computational mathematics in science and engineering [PDF]

International Journal of Computer Mathematics, 2011
We are pleased to offer readers of International Journal of Computer Mathematics this Special Issue consisting of some of the most significant contributions presented at the 9th International Confe...
Jesús Vigo-Aguiar, Juan Antonio López Ramos   +1 more
openaire   +1 more source