Results 71 to 80 of about 307,993 (262)
FEBS Letters, EarlyView.We reconstituted Synechocystis glycogen synthesis in vitro from purified enzymes and showed that two GlgA isoenzymes produce glycogen with different architectures: GlgA1 yields denser, highly branched glycogen, whereas GlgA2 synthesizes longer, less‐branched chains.
Kenric Lee +3 more
wiley +1 more source
Structural biology of ferritin nanocages
FEBS Letters, EarlyView.Ferritin is a conserved iron‐storage protein that sequesters iron as a ferric mineral core within a nanocage, protecting cells from oxidative damage and maintaining iron homeostasis. This review discusses ferritin biology, structure, and function, and highlights recent cryo‐EM studies revealing mechanisms of ferritinophagy, cellular iron uptake, and ...
Eloise Mastrangelo, Flavio Di Pisa
wiley +1 more source
FEBS Letters, EarlyView.In this study, we found that human cervical‐derived adipocytes maintain intracellular iron level by regulating the expression of iron transport‐related proteins during adrenergic stimulation. Melanotransferrin is predicted to interact with transferrin receptor 1 based on in silico analysis.
Rahaf Alrifai +9 more
wiley +1 more source
Applied Computational Intelligence and Soft ComputingAcute lymphoblastic leukemia (ALL) is a type of blood cancer that rapidly impacts the hematologic system, particularly in children, requiring accurate and prompt diagnosis for better clinical outcomes. Manual inspection of peripheral blood smears remains
Aziz Makandar +6 more
doaj +1 more source
Deep Residual Transfer Ensemble Model for mRNA Gene-Expression-Based Breast Cancer
IEEE AccessThe last few years have witnessed exponential rise in breast cancer disease. The increasing mortality rate due to the lack of earlier diagnosis has alarmed healthcare industry to develop more efficient and scalable computer aided diagnosis (CAD) solution.
Job Prasanth Kumar Chinta Kunta +1 more
doaj +1 more source
Tau acetylation at K331 has limited impact on tau pathology in vivo
FEBS Letters, EarlyView.We mapped tau post‐translational modifications in humanized MAPT knock‐in mice and in amyloid‐bearing double knock‐in mice. Acetylation within the repeat domain, particularly around K331, showed modest increases under amyloid pathology. To test functional relevance, we generated MAPTK331Q knock‐in mice.
Shoko Hashimoto +3 more
wiley +1 more source
Calpain small subunit homodimerization is robust and calcium‐independent
FEBS Letters, EarlyView.Calpains dimerize via penta‐EF‐hand (PEF) domains. Using single‐molecule force spectroscopy, we measured the strength and kinetics of PEF–PEF homodimer binding. The interaction is robust, shows a transient conformational step before dissociation, and remains largely insensitive to Ca2+.
Nesha May O. Andoy +4 more
wiley +1 more source
Structural insights into an engineered feruloyl esterase with improved MHET degrading properties
FEBS Letters, EarlyView.A feruloyl esterase was engineered to mimic key features of MHETase, enhancing the degradation of PET oligomers. Structural and computational analysis reveal how a point mutation stabilizes the active site and reshapes the binding cleft, expading substrate scope.
Panagiota Karampa +5 more
wiley +1 more source
Discover ComputingThe sequential three-way decision accepts additional information at each level and makes more accurate definite decisions with less uncertainty. This process can also be extended to two-way classification with the finer-grained information level. However,
T. V. Soumya, M. K. Sabu
doaj +1 more source
EvoSMS: An Event-Oriented Simulation Method for Multi-Core Real-Time Scheduling
Applied SciencesIn this paper, an event-oriented simulation analysis approach was established for the schedulability analysis of multi-core embedded systems. To the best of our knowledge, this work is the first to introduce an event-oriented simulation strategy into ...
Xianchen Shi +3 more
doaj +1 more source