Results 31 to 40 of about 27,419 (227)
Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment
Molecular Oncology, EarlyView.This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley +1 more source
Construction of a support tool for the design of the activity structures based computer system architectures [PDF]
, 1986 This thesis was submitted for the degree of Doctor of Philosophy and was awarded by Brunel University.This thesis is a reapproachment of diverse design concepts, brought to bear upon the computer system engineering problem of identification and control ...
Mohamad, Sabah Mohamad Amin
core
Interrogating the immune landscape of microsatellite stable RAS‐mutated colon cancer
Molecular Oncology, EarlyView.COLOSSUS project RAS‐mutated MSS colon cancer study explored transcriptomics and immune cell density by immunohistochemistry (IHC), Immunoscore (IS), ISIC/TuLIS scores, mutation counts, and detected different prevalences but similar microenvironment composition across immune markers with clinical relevance for future immunotherapy combination ...
Rodrigo Dienstmann +61 more
wiley +1 more source
Nature and role of intermediate representation (IR) in the design process [PDF]
, 2005 This paper aims to show the key role of the intermediate representations (IR) in the design process and especially in the car design process. For a better understanding of the concept of design, which is by nature conceptual, we propose to study the ...
AOUSSAT, Améziane +2 more
core
A Tale of Three Sites: Resource and Knowledge Sharing Amongst Computer Science Educators [PDF]
, 2013 Computer science educators, especially those in schools, often work in small departments which allow little support or sharing. This problem can be alleviated via virtual online communities that allow educators to support each other and share knowledge ...
Brown, Neil Christopher Charles +3 more
core +1 more source
Molecular Oncology, EarlyView.We identify USP29 as the only DUB mirroring CA9 expression, a marker of hypoxia and HIF pathway activation associated with PCA aggressiveness. USP29 stabilizes HIF‐1α and HIF‐2α via a noncanonical mechanism that is independent of PHD/pVHL activity yet relies on proteasomal regulation, establishing USP29 as a previously unrecognized regulator of hypoxic
Amelie S Schober +16 more
wiley +1 more source
Distributed cognition and computer supported collaborative design: The organisation of work in construction engineering [PDF]
, 1997 This thesis was submitted for the degree of Doctor of Philosophy and awarded by Brunel University.The intellectual contribution of this thesis lies within the area of computer supported co-operative work (CSCW), and more specifically, computer supported ...
Perry, Mark Julian
core
Liquid biopsy‐based diagnostic evaluation of hypermethylated CpG sites for ovarian cancer diagnosis
Molecular Oncology, EarlyView.This schematic outlines the workflow from biomarker identification to duplex MethyLight assay validation for epithelial ovarian cancer diagnosis using cfDNA‐based liquid biopsy. Initial screening of hypermethylated CpG candidates (cg02957270, cg10061138 cg00480298, COL2A1) was performed in tissue using ARMS‐PCR, COBRA, qPCR and image analysis. Selected
Deepa Bisht +3 more
wiley +1 more source
The principles of screen design for computer-based learning materials. [PDF]
, 1994 The critical interface between learners and computer-based learning materials is the screen. If the display of learning is not effective then learning will be hindered.
Clarke, Alan, Clarke, A.
core
Role of sketching in conceptual design of car styling [PDF]
, 2006 This paper aims at studying the role of sketching in car styling. Prior studies have shown that sketches play a major role in the early phases of design.
AOUSSAT, Améziane +5 more
core +1 more source