Results 111 to 120 of about 291,136 (309)
Interrogating the immune landscape of microsatellite stable RAS‐mutated colon cancer
Molecular Oncology, EarlyView.COLOSSUS project RAS‐mutated MSS colon cancer study explored transcriptomics and immune cell density by immunohistochemistry (IHC), Immunoscore (IS), ISIC/TuLIS scores, mutation counts, and detected different prevalences but similar microenvironment composition across immune markers with clinical relevance for future immunotherapy combination ...
Rodrigo Dienstmann +61 more
wiley +1 more source
Computer science as an integrated part of engineering education
, 1998 The Information Technology curriculum at Linköping University has as goal to form engineers with an integrated view of engineering. The teaching philosophy in this curriculum is Problem-Based Learning.
Kamkar, Mariam, +3 more
core +1 more source
Molecular Oncology, EarlyView.Cytarabine is a key therapy for acute myeloid leukaemia (AML), but its efficacy is limited by the dNTPase SAMHD1, which hydrolyses its active metabolite. Screening nucleotide biosynthesis inhibitors revealed that IMPDH inhibitors selectively sensitise SAMHD1‐proficient AML cells to cytarabine.
Miriam Yagüe‐Capilla +9 more
wiley +1 more source
The State of Computer Science in National Colleges And Universities
, 1983 The author served on the State Council for Higher Education in Virginia (SCHEV) task force on computer science education during the academic year 1983; this report was originally offered as the first chapter in the report of that task force.
Lee, John A. N.
core
Molecular Oncology, EarlyView.Targeted therapy was evaluated in SHH medulloblastoma using neuroepithelial stem cell (NES) and tumor‐derived NES‐like (tNES) models in 2D monolayers and 3D spheroids. PI3K, AKT, and CDK4/6 inhibitors had minimal effects in NES but markedly reduced viability and growth and induced apoptosis in tNES cells, revealing distinct therapeutic vulnerabilities.
Monika Lukoseviciute +4 more
wiley +1 more source
Molecular Oncology, EarlyView.Pancreatic sensory neurons innervating healthy and PDAC tissue were retrogradely labeled and profiled by single‐cell RNA sequencing. Tumor‐associated innervation showed a dominant neurofilament‐positive subtype, altered mitochondrial gene signatures, and reduced non‐peptidergic neurons.
Elena Genova +14 more
wiley +1 more source
Analysis of Sentiment Toward Computer Science in Pre-University Education
IEEE AccessEmotions are essential drivers of the learning process, influencing motivation, performance, and problem-solving abilities. In the field of Computer Science, students often struggle with negative emotions during programming activities, impacting their ...
Rafael Herrero-Alvarez +3 more
doaj +1 more source
The impact of computer use in the development of Mathematics teaching in primary education
, 2011 This thesis was submitted for the degree of Doctor of Philosophy and awarded by Brunel University.The educational system in Kuwait is intended to provide primary and secondary students with required skills in order to operate in the technical careers ...
Alawadhi, Nabil
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CCDC80 suppresses high‐grade serous ovarian cancer migration via negative regulation of B7‐H3
Molecular Oncology, EarlyView.PAX8 is a lineage‐specific master regulator of transcription in high‐grade serous ovarian cancer (HGSC) progression. We show for the first time that PAX8 facilitates proliferation and metastasis by repressing the cell autonomous tumor suppressor CCDC80 and inducing B7‐H3 expression.
Aya Saleh +12 more
wiley +1 more source
Virtual reality applications in computer science education: scoping review
Computers & Education: X RealityThis scoping review explores the application of virtual reality (VR) technologies to computer science (CS) education. With the increasing scholarly interest in immersive and interactive learning, VR exhibits a strong potential in helping learners ...
Azin S. Janani +4 more
doaj +1 more source