Results 21 to 30 of about 659,160 (268)
STAR Protocols, 2023 Summary: Biomedical knowledge graphs (BKGs) provide a new paradigm for managing abundant biomedical knowledge efficiently. Today’s artificial intelligence techniques enable mining BKGs to discover new knowledge.
Chang Su +4 more
doaj +1 more source
FEBS Letters, EarlyView.Knowing how proteases recognise preferred substrates facilitates matching proteases to applications. The S1′ pocket of protease EA1 directs cleavage to the N‐terminal side of hydrophobic residues, particularly leucine. The S1′ pocket of thermolysin differs from EA's at only one position (leucine in place of phenylalanine), which decreases cleavage ...
Grant R. Broomfield +3 more
wiley +1 more source
Protocol for enhancing visualization clarity for categorical spatial datasets using Spaco
STAR ProtocolsSummary: In categorical data visualization, appropriate color arrangements can avoid perceptual ambiguity and help perceive underlying data patterns. We introduce a protocol to assign contrastive colors to neighboring categories using both Python and R ...
Zehua Jing, Bolin Yang, Yinqi Bai
doaj +1 more source
Exploring lipid diversity and minimalism to define membrane requirements for synthetic cells
FEBS Letters, EarlyView.Designing the lipid membrane of synthetic cells is a complex task, in which its various roles (among them solute transport, membrane protein support, and self‐replication) should all be integrated. In this review, we report the latest top‐down and bottom‐up advances and discuss compatibility and complexity issues of current engineering approaches ...
Sergiy Gan +2 more
wiley +1 more source
Protocol for designing, optimizing, and analyzing reverse supply chains using RELOG
STAR Protocols, 2023 Summary: In this protocol, we describe the use of RELOG, an open-source, supply chain optimization package, for robust design and analysis of optimal reverse logistics and manufacturing networks.
Chukwunwike O. Iloeje +4 more
doaj +1 more source
FEBS Letters, EarlyView.The Arabidopsis mutants hls1 hlh1 and amp1 lamp1 exhibit pleiotropic developmental phenotypes. Although the functions of the causative genes remain unclear, they act in the same genetic pathway and are thought to generate non‐cell‐autonomous signals.
Takashi Nobusawa, Makoto Kusaba
wiley +1 more source
Non-negative tensor factorization workflow for time series biomedical data
STAR Protocols, 2023 Summary: Non-negative tensor factorization (NTF) enables the extraction of a small number of latent components from high-dimensional biomedical data. However, NTF requires many steps, which is a hurdle to implementation.
Koki Tsuyuzaki +4 more
doaj +1 more source
Microbial exopolysaccharide production by polyextremophiles in the adaptation to multiple extremes
FEBS Letters, EarlyView.Polyextremophiles are microorganisms that endure multiple extreme conditions by various adaptation strategies that also include the production of exopolysaccharides (EPSs). This review provides an integrated perspective on EPS biosynthesis, function, and regulation in these organisms, emphasizing their critical role in survival and highlighting their ...
Tracey M Gloster, Ebru Toksoy Öner
wiley +1 more source
FEBS Letters, EarlyView.Phytohormone brassinosteroid‐induced gene regulation by the transcription factor BIL1/BZR1 involves redox‐dependent DNA‐binding alternation and interaction with the transcription factor PIF4. The reduced BIL1/BZR1 dimer binds preferred cis‐elements, while oxidation alters its oligomerization state and disrupts DNA‐binding ability.
Shohei Nosaki +4 more
wiley +1 more source
STAR ProtocolsSummary: Here, we present a protocol for implementing the nested model for developing and validating artificial intelligence (AI) systems in compliance with AI regulations.
Akshat Dubey +3 more
doaj +1 more source