Results 91 to 100 of about 5,429,849 (294)

An Attempt to Simulate the Liver on a Computer [PDF]

The Computer Journal, 1962
This paper records methods which we have used in efforts to simulate the way the liver functions. The equations which we have investigated may be similar to others of interest in the theory of chemical extraction plants, and our results may therefore be of interest in other fields besides physiology. Here, we are chiefly concerned with mathematical and
J. M. Watt, Andrew Young
openaire   +3 more sources

Transcripts enriched in codons that trigger P‐site tRNA‐mediated mRNA decay possess stable mRNA

FEBS Open Bio, EarlyView.
PTMD codons were first described by Mendel et al. as mediators of an mRNA decay pathway dependent on the human protein CNOT3, homologous to yeast Not5. Our findings confirm that PTMD codons destabilize transcripts; however, unlike in yeast, the human pathway specifically targets and slightly destabilizes primarily stable mRNAs.
Rodolfo Lopes Carneiro, Fernando Lucas Palhano   +1 more
wiley   +1 more source

Malformin A1–mediated cytotoxicity in ovarian cancer cells occurs through pyroptosis and autophagy

FEBS Open Bio, EarlyView.
This study investigated the effects of the natural compound Malformin A1 (MA1) on the cytoskeleton that regulates cell proliferation and migration. Disruption of the cytoskeleton can impair these processes and promote cancer cell death. MA1 disrupted cytoskeletal organization, induced DNA damage, inflammation, activated autophagy, and pyroptosis ...
Nada Abdullah Hassan, Ikram A. Burney, Shika Hanif Malgundkar, Siva Ramamoorthy, Ressin Varghese, Mohamed A. Al‐Kindi, Hamad Al Riyami, Shadia Al Bahlani, Sergey Dobretsov, Syed Imran Hassan, Benjamin K. Tsang, Yahya Tamimi   +11 more
wiley   +1 more source

Regional impacts of solar radiation modification on surface temperature and precipitation in Mainland Southeast Asia and the adjacent oceans

Scientific Reports
Solar radiation modification (SRM) has been proposed to temporarily reduce anthropogenic warming. This study presents an assessment of the regional impacts of SRM via solar dimming and stratospheric aerosol injection (SAI) on temperature and ...
Pornampai Narenpitak, Siriwat Kongkulsiri, Saifhon Tomkratoke, Sirod Sirisup   +3 more
doaj   +1 more source

Identifying and characterising a plant GH1 β‐glucosidase that exhibits hydrolytic activity on N‐linked glucopyranoside

FEBS Open Bio, EarlyView.
We report the first β‐glucosidase with demonstrated hydrolytic activity on an N‐linked glycopyranoside. The enzyme, native to maize, was biochemically characterised for this novel reaction, and structural modelling of the enzyme–substrate complex revealed several clues to the underlying reduced catalytic rate relative to its native O‐glycopyranoside ...
Hani Gharabli, Carlotta Chiesa, Maher Abou Hachem, Ditte Hededam Welner   +3 more
wiley   +1 more source

Structural studies and functional engineering of NanX: an anhydro‐sialic acid transporter from Escherichia coli

FEBS Open Bio, EarlyView.
Biophysical characterisation shows that NanX, a membrane transport protein from the major facilitator superfamily (MFS), forms both monomers and dimers after purification. AlphaFold modelling and substrate docking provide information on residues likely involved in substrate recognition for NanX and another MFS member, NanT.
Michael C. Newton‐Vesty, Kelsi R. Hall, Zachary D. Tillett, Liam S. Turk, James S. Davies, Michael J. Currie, Hamish G. Brown, Sepideh Valimehr, Peter D. Mace, Andrew E. Whitten, Santosh Panjikar, Eric Hanssen, Rachel A. North, Renwick C.J. Dobson   +13 more
wiley   +1 more source

5G High Density Demand Dataset in Liverpool City Region, UK

Scientific Data
The wireless network data are a feasible way to understand the user behavior in a given environment and may be utilized for analysis, prediction and optimization. On the other hand, datasets from wireless service providers are not publicly available, and
Mukesh Kumar Maheshwari, Alessandro Raschellà, Michael Mackay, Max Hashem Eiza, Jon Wetherall, Jen Laing   +5 more
doaj   +1 more source

NESTML: a generic modeling language and code generation tool for the simulation of spiking neural networks with advanced plasticity rules

Frontiers in Neuroinformatics
With increasing model complexity, models are typically re-used and evolved rather than starting from scratch. There is also a growing challenge in ensuring that these models can seamlessly work across various simulation backends and hardware platforms ...
Charl Linssen, Charl Linssen, Charl Linssen, Pooja N. Babu, Pooja N. Babu, Jochen M. Eppler, Luca Koll, Bernhard Rumpe, Abigail Morrison, Abigail Morrison   +9 more
doaj   +1 more source

Adenosine triphosphate as a modulator of protein interactions and stability

FEBS Open Bio, EarlyView.
ATP is best known as the cell's energy currency, but it also shapes how proteins fold, interact, aggregate and form biomolecular condensates. This review explains the emerging physical principles behind these effects, including weak binding to charged protein regions, magnesium‐dependent behaviour and concentration‐dependent control of protein ...
Shuyuan Tan, Robin Curtis
wiley   +1 more source

Recent insights into the molecular mechanism of ubiquinol oxidation by cytochrome bc1

FEBS Open Bio, EarlyView.
The review reflects on the mechanism of the catalytic reaction in cytochrome bc1: the electron bifurcation that involves the separation of two electrons derived from the quinol oxidation to opposite sides of the enzyme across the membrane. This review summarizes the long‐standing effort to understand the mechanism of quinol oxidation catalyzed by ...
Anna Wójcik‐Augustyn, Artur Osyczka, Marcin Sarewicz   +2 more
wiley   +1 more source