Results 101 to 110 of about 9,093,329 (381)

A unified model for Duchenne muscular dystrophy gene involvement in cancer: context‐dependent tumour suppression and oncogenicity

FEBS Open Bio, EarlyView.
We propose a context‐dependent model where the Duchenne muscular dystrophy (DMD) gene acts as a tumour suppressor in aggressive tumours and as an oncogene in less aggressive ones. We propose this model as a unified framework to explain the opposing survival associations with DMD expression and to guide experimental exploration of the dual role of DMD ...
Lee Machado, Leanne Jones, Sonika Divakar, Michael Naidoo, Karen Anthony   +4 more
wiley   +1 more source

Evolutionary games and computer simulations. [PDF]

Proceedings of the National Academy of Sciences, 1993
The Prisoner's Dilemma has long been considered the paradigm for studying the emergence of cooperation among selfish individuals. Because of its importance, it has been studied through computer experiments as well as in the laboratory and by analytical means. However, there are important differences between the way a system composed of many interacting
Bernardo A. Huberman, Natalie S. Glance
openaire   +4 more sources

Structural and functional characterization of chitinase from carnivorous plant Drosera adelae

FEBS Open Bio, EarlyView.
A class I chitinase from the carnivorous plant Drosera adelae was expressed and purified using a yeast system, revealing high enzymatic activity. Structural analyses of the catalytic and chitin‐binding domains identified key tyrosine residues involved in substrate binding, offering insights into the enzyme's adaptation for insect digestion.
Kazunari Yoneda, Yuki Naruse, Yusaku Suizu, Tomohiro Araki, Yoshikazu Hoshi, Haruhiko Sakuraba, Junji Hayashi, Toshihisa Ohshima   +7 more
wiley   +1 more source

When medical trainees encountering a performance difficulty: evidence from pupillary responses

BMC Medical Education, 2022
Background Medical trainees are required to learn many procedures following instructions to improve their skills. This study aims to investigate the pupillary response of trainees when they encounter moment of performance difficulty (MPD) during skill ...
Xin Liu, Yerly Paola Sanchez Perdomo, Bin Zheng, Xiaoqin Duan, Zhongshi Zhang, Dezheng Zhang   +5 more
doaj   +1 more source

Instructional Design and Facilitation for Multigenerational Online Learning in Higher Education—Baby Boomers, Generation X, Millennials, and Generation Z

New Directions for Adult and Continuing Education, EarlyView.
ABSTRACT Nontraditional students represent a substantial number and significant percentage of students in higher education. While these adult learners have similarities, they also span 50+ years with generational differences. At the same time, online learning is on the rise, offering opportunities and challenges for nontraditional students and those ...
Brittany Hyden, Catherine A. Cherrstrom
wiley   +1 more source

NESTML: a generic modeling language and code generation tool for the simulation of spiking neural networks with advanced plasticity rules

Frontiers in Neuroinformatics
With increasing model complexity, models are typically re-used and evolved rather than starting from scratch. There is also a growing challenge in ensuring that these models can seamlessly work across various simulation backends and hardware platforms ...
Charl Linssen, Charl Linssen, Charl Linssen, Pooja N. Babu, Pooja N. Babu, Jochen M. Eppler, Luca Koll, Bernhard Rumpe, Abigail Morrison, Abigail Morrison   +9 more
doaj   +1 more source

Phase diagram of silica from computer simulation

, 2004
We evaluate the phase diagram of the ``BKS'' potential [Van Beest, Kramer and van Santen, Phys. Rev. Lett. 64, 1955 (1990)], a model of silica widely used in molecular dynamics (MD) simulations. We conduct MD simulations of the liquid, and three crystals
Francesco Sciortino, I. Saika-Voivod, Ivan Saika-Voivod, M. Allen, Peter H. Poole, Tor Grande, W. Press   +6 more
core   +1 more source

The Road Not Taken: Misclassifying an Anti‐Seizure Medication as a Failure

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective To quantify how often anti‐seizure medications (ASMs) appear ineffective yet provide benefit when considering seizure frequency (SF) variability. Methods We used the CHOCOLATES seizure diary simulator to generate 100,000 patient seizure diaries that reflect natural SF variation in a heterogeneous population.
Christopher N. Henry, Daniel M. Goldenholz   +1 more
wiley   +1 more source

Optimal saturated information load analysis for enhancing robustness in unmanned swarms system

Complex & Intelligent Systems
Saturated information load is defined as the information received by a unmanned aerial vehicle (UAV) node in a swarm network reaches the overload limit of its processing capability.
Jian Wu, Yichuan Jiang, Junjun Tang, Linfei Ding   +3 more
doaj   +1 more source

Overview of crowd simulation in computer graphics [PDF]

, 2008
High-powered technology use computer graphics in education, entertainment, games, simulation, and virtual heritage applications has led it to become an important area of research. In simulation, according to Tecchia et al.
Daman, Daut, Mohamed Azahar, Mohamed Adi
core