Results 31 to 40 of about 286,531 (240)

Structural instability impairs function of the UDP‐xylose synthase 1 Ile181Asn variant associated with short‐stature genetic syndrome in humans

open access: yesFEBS Letters, EarlyView.
The Ile181Asn variant of human UDP‐xylose synthase (hUXS1), associated with a short‐stature genetic syndrome, has previously been reported as inactive. Our findings demonstrate that Ile181Asn‐hUXS1 retains catalytic activity similar to the wild‐type but exhibits reduced stability, a looser oligomeric state, and an increased tendency to precipitate ...
Tuo Li   +2 more
wiley   +1 more source

A dual coil induction heating machine for jewelry factories developed by electromagnetic analysis

open access: yesJournal of Advanced Joining Processes, 2023
An induction heating machine (IHM) generates magnetic flux density (B) and high temperature for combining precious metals as products in a jewelry factory.
Sorathorn Pattanapichai   +2 more
doaj   +1 more source

Transferrin receptor 1‐mediated iron uptake supports thermogenic activation in human cervical‐derived adipocytes

open access: yesFEBS Letters, EarlyView.
In this study, we found that human cervical‐derived adipocytes maintain intracellular iron level by regulating the expression of iron transport‐related proteins during adrenergic stimulation. Melanotransferrin is predicted to interact with transferrin receptor 1 based on in silico analysis.
Rahaf Alrifai   +9 more
wiley   +1 more source

Harmonic Response Analysis of Tank Design Effect on Ultrasonic Cleaning Process

open access: yesFluids, 2022
Several ultrasonic cleaning tanks (UCTs) had a problem: a manufacturer complained that there were damages to cleaning objects, they were unclarified, and it needed to be abruptly solved.
Suchada Phophayu   +2 more
doaj   +1 more source

Structural insights into an engineered feruloyl esterase with improved MHET degrading properties

open access: yesFEBS Letters, EarlyView.
A feruloyl esterase was engineered to mimic key features of MHETase, enhancing the degradation of PET oligomers. Structural and computational analysis reveal how a point mutation stabilizes the active site and reshapes the binding cleft, expading substrate scope.
Panagiota Karampa   +5 more
wiley   +1 more source

Computer simulation of CRS populations

open access: yesCalifornia Agriculture, 1985
California red scale is one of the thre major arthropodpests of citrus in California, causing an anual economic crop los of aproximately $1 5 milion. CRS infestations can lower the market grade of fruit as wel as cause reduced tre vigor and twig and ...
J Morse, M Arbaugh, D Moreno
doaj  

A methionine‐lined active site governs carbocation stabilization and product specificity in a bacterial terpene synthase

open access: yesFEBS Letters, EarlyView.
This study reveals a unique active site enriched in methionine residues and demonstrates that these residues play a critical role by stabilizing carbocation intermediates through novel sulfur–cation interactions. Structure‐guided mutagenesis further revealed variants with significantly altered product profiles, enhancing pseudopterosin formation. These
Marion Ringel   +13 more
wiley   +1 more source

Aggressive prostate cancer is associated with pericyte dysfunction

open access: yesMolecular Oncology, EarlyView.
Tumor‐produced TGF‐β drives pericyte dysfunction in prostate cancer. This dysfunction is characterized by downregulation of some canonical pericyte markers (i.e., DES, CSPG4, and ACTA2) while maintaining the expression of others (i.e., PDGFRB, NOTCH3, and RGS5).
Anabel Martinez‐Romero   +11 more
wiley   +1 more source

Peroxidasin enables melanoma immune escape by inhibiting natural killer cell cytotoxicity

open access: yesMolecular Oncology, EarlyView.
Peroxidasin (PXDN) is secreted by melanoma cells and binds the NK cell receptor NKG2D, thereby suppressing NK cell activation and cytotoxicity. PXDN depletion restores NKG2D signaling and enables effective NK cell–mediated melanoma killing. These findings identify PXDN as a previously unrecognized immune evasion factor and a potential target to improve
Hsu‐Min Sung   +17 more
wiley   +1 more source

Thermo-Responsive Molecularly Imprinted Hydrogels for Selective Adsorption and Controlled Release of Phenol From Aqueous Solution

open access: yesFrontiers in Chemistry, 2019
In this study, thermo-responsive molecularly imprinted hydrogels (T-MIHs) were developed as an effective potential adsorbent for selectively adsorption phenol from wastewater.
Zhenhui Si   +14 more
doaj   +1 more source

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