Results 41 to 50 of about 1,797,323 (298)

A methionine‐lined active site governs carbocation stabilization and product specificity in a bacterial terpene synthase

FEBS Letters, EarlyView.
This study reveals a unique active site enriched in methionine residues and demonstrates that these residues play a critical role by stabilizing carbocation intermediates through novel sulfur–cation interactions. Structure‐guided mutagenesis further revealed variants with significantly altered product profiles, enhancing pseudopterosin formation. These
Marion Ringel, Carl P. O. Helmer, Shani Zev, Ronja Driller, Emily Buhr, Markus Reinbold, Renana Schwartz, Gabriel Foley, Mikael Boden, Daniel Garbe, Gerhard Schenk, Dan Thomas Major, Bernhard Loll, Thomas Brück   +13 more
wiley   +1 more source

Revisit Point Cloud Recognition From the Viewpoint of Data Mixture

IEEE Access, 2020
In recent years, point cloud based data analysis has attracted lots of attentions of researchers from many different fields because of its simplicity and effectiveness.
Zhenzhong Kuang, Xin Zhang, Zhiqiang Guo
doaj   +1 more source

Peroxidasin enables melanoma immune escape by inhibiting natural killer cell cytotoxicity

Molecular Oncology, EarlyView.
Peroxidasin (PXDN) is secreted by melanoma cells and binds the NK cell receptor NKG2D, thereby suppressing NK cell activation and cytotoxicity. PXDN depletion restores NKG2D signaling and enables effective NK cell–mediated melanoma killing. These findings identify PXDN as a previously unrecognized immune evasion factor and a potential target to improve
Hsu‐Min Sung, David Bickel, Lena C. M. Krause, Daria Ezeriņa, Christian Ickes, Julian Wojtachnia, Christine S. Gibhardt, Magdalena Shumanska, Khadija Wahni, Andrea Paluschkiwitz, Julia Malo Pueyo, Ekaterina Baranova, Wim Vranken, Hedwig Stanisz, Ioana Stejerean‐Todoran, Michael P. Schön, Joris Messens, Ivan Bogeski   +17 more
wiley   +1 more source

Computer simulation of CRS populations

California Agriculture, 1985
California red scale is one of the thre major arthropodpests of citrus in California, causing an anual economic crop los of aproximately $1 5 milion. CRS infestations can lower the market grade of fruit as wel as cause reduced tre vigor and twig and ...
J Morse, M Arbaugh, D Moreno
doaj  

A dual coil induction heating machine for jewelry factories developed by electromagnetic analysis

Journal of Advanced Joining Processes, 2023
An induction heating machine (IHM) generates magnetic flux density (B) and high temperature for combining precious metals as products in a jewelry factory.
Sorathorn Pattanapichai, Thodsaphon Jansaengsuk, Jatuporn Thongsri   +2 more
doaj   +1 more source

Text-based LSTM networks for Automatic Music Composition [PDF]

, 2016
In this paper, we introduce new methods and discuss results of text-based LSTM (Long Short-Term Memory) networks for automatic music composition.
CHOI, K, Conference on Computer Simulation of Musical Creativity, fazekas, G, sandler, M   +3 more
core  

Keratin 19 as a prognostic marker and contributing factor of metastasis and chemoresistance in high‐grade serous ovarian cancer

Molecular Oncology, EarlyView.
Keratin 19 (KRT19) is overexpressed in high‐grade serous ovarian cancer with high levels of Kallikrein‐related peptidases (KLK) 4–7 and is associated with poor survival. In vivo analyses demonstrate that elevated KRT19 increases peritoneal tumour burden.
Sophia Bielesch, Isabel Vogel, Sina Nokodian, Johanna Moeller, Antonia Blechschmidt, Vicky Hecht, Vanessa Kuentzel, Katharina Thiedig, Melissa Schwab, Oliver Schilling, Holger Bronger, Marion Kiechle, Viktor Magdolen, Tobias Dreyer   +13 more
wiley   +1 more source

A data‐driven inertia adequacy‐based approach for sustainable expansion planning in distributed generations‐penetrated power grids

IET Generation, Transmission & Distribution, 2022
Reduced rotational inertia in power grids due to increasing penetration levels of distributed generations (DGs) may lead to degraded performance of the traditional frequency control scheme.
Hêmin Golpîra, Shiva Amini, Azin Atarodi, Hassan Bevrani   +3 more
doaj   +1 more source

Establishment of a humanized patient‐derived xenograft mouse model of high‐grade serous ovarian cancer for preclinical evaluation of combination immunotherapy

Molecular Oncology, EarlyView.
We have established a humanized orthotopic patient‐derived xenograft (Hu‐oPDX) mouse model of high‐grade serous ovarian cancer (HGSOC) that recapitulates human tumor–immune interactions. Using combined anti‐PD‐L1/anti‐CD73 immunotherapy, we demonstrate the model's improved biological relevance and enhanced translational value for preclinical ...
Luka Tandaric, Line Bjørge, Martine Rott Lode, Cecilie Fredvik Torkildsen, Pia Aehnlich, Rammah Elnour, Daniela Elena Costea, Lars Andreas Akslen, Liv Cecilie Vestrheim Thomsen, Emmet McCormack, Katrin Kleinmanns   +10 more
wiley   +1 more source

Harmonic Response Analysis of Tank Design Effect on Ultrasonic Cleaning Process

Fluids, 2022
Several ultrasonic cleaning tanks (UCTs) had a problem: a manufacturer complained that there were damages to cleaning objects, they were unclarified, and it needed to be abruptly solved.
Suchada Phophayu, Ketmanee Kliangklom, Jatuporn Thongsri   +2 more
doaj   +1 more source