Results 61 to 70 of about 5,429,849 (294)

Invisible but not inaccessible—Revealing transient oligomers formed by intrinsically disordered proteins with solution NMR and complementary methods

open access: yesFEBS Letters, EarlyView.
Transient oligomers formed by intrinsically disordered proteins may be ‘invisible’ to direct detection yet remain accessible to solution NMR through equilibrium‐exchange measurements and pressure‐jump experiments. Complementary methods report on mass, stoichiometry, selected distance distributions, morphology, and internal packing.
Martin D. Gelenter, Ad Bax
wiley   +1 more source

A dual coil induction heating machine for jewelry factories developed by electromagnetic analysis

open access: yesJournal of Advanced Joining Processes, 2023
An induction heating machine (IHM) generates magnetic flux density (B) and high temperature for combining precious metals as products in a jewelry factory.
Sorathorn Pattanapichai   +2 more
doaj   +1 more source

Developmental programmes drive cellular plasticity, disease progression and therapy resistance in lung adenocarcinoma

open access: yesMolecular Oncology, EarlyView.
This study shows that lung adenocarcinomas exploit developmental branching morphogenesis to acquire a therapy resistant basal‐like tumour cell state. This process was found to be regulated by combined TP53 loss‐of‐function and type‐I interferon signalling, identifying a novel axis for biomarker and therapeutic target discovery.
Kamila J Bienkowska   +13 more
wiley   +1 more source

Network modelling and simulation tools [PDF]

open access: yes, 2009
Computer network technologies have been growing explosively and the study in computer networks is being a challenging task. To make this task easy, different users, researchers and companies have developed different network modelling and simulation (MS ...
Pakstas, Algirdas   +2 more
core   +1 more source

MITF maintains genome stability in nonmelanocyte lineages

open access: yesMolecular Oncology, EarlyView.
MITF is essential for melanocyte survival and acts as an oncogene in 10%–20% of melanomas. We show that MITF depletion causes genome instability in nonmelanocytic cells, leading to LATS2‐mediated P53 activation, cell cycle arrest, and apoptosis. This study highlights the role of MITF as a genome maintenance factor beyond the melanocyte lineage. Created
Drifa H. Gudmundsdottir   +13 more
wiley   +1 more source

Computer‐simulated experiments and computer games: A method of design analysis [PDF]

open access: yes, 1995
This paper describes a new research programme to design computer‐simulated experiments in the field of fuels and combustion, and describes a method of categorization based on a taxonomy proposed by Gredler.
Jerome J. Leary, Leary, Jerome
core   +1 more source

Computer simulation of a novel pharmaceutical silicon nanocarrier

open access: yesNanotechnology, Science and Applications, 2010
Saeed Soltani, Soroush Sardari, Sima Azadi SororDrug Design and Bioinformatics Unit, Medical Biotechnology Department, Biotechnology Research Center, Pasteur Institute of Iran, Tehran, IranAbstract: We show the potential of the nanosilicon structure of ...
Saeed Soltani   +2 more
doaj  

Harmonic Response Analysis of Tank Design Effect on Ultrasonic Cleaning Process

open access: yesFluids, 2022
Several ultrasonic cleaning tanks (UCTs) had a problem: a manufacturer complained that there were damages to cleaning objects, they were unclarified, and it needed to be abruptly solved.
Suchada Phophayu   +2 more
doaj   +1 more source

A novel quinazolinone insulin receptor inhibitor and its synergy with an EGFR inhibitor in glucose‐driven glioblastoma

open access: yesMolecular Oncology, EarlyView.
The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka   +9 more
wiley   +1 more source

Computer simulation for undergraduate engineering education

open access: yes, 2009
Computer simulation has been popularly used in education for a few decades while its effects on engineering curriculum do not achieve so much success as on other curriculum.
Xia Hong   +9 more
core   +1 more source

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