Results 61 to 70 of about 295,466 (267)

Developmental programmes drive cellular plasticity, disease progression and therapy resistance in lung adenocarcinoma

Molecular Oncology, EarlyView.
This study shows that lung adenocarcinomas exploit developmental branching morphogenesis to acquire a therapy resistant basal‐like tumour cell state. This process was found to be regulated by combined TP53 loss‐of‐function and type‐I interferon signalling, identifying a novel axis for biomarker and therapeutic target discovery.
Kamila J Bienkowska, Stephany Gallardo, Nur S. Zainal, Leena Arora, Matthew Ellis, Maria‐Antoinette Lopez, Judith Austine, Sai Pittla, Serena J Chee, Aiman Alzetani, Emily C Shaw, Christian H Ottensmeier, Gareth J Thomas, Christopher J Hanley   +13 more
wiley   +1 more source

Design of Intelligent Control Law Embedded With Dynamic Flow Field Perception Method for High-Angle-of-Attack Maneuvers of Numerical Virtual Flight Agent

International Journal of Aerospace Engineering
In numerical virtual flight (NVF) tasks, strong unsteady flow disturbances can change aerodynamic behavior and reduce the effectiveness of control surfaces, increase the difficulty of aerodynamics modeling and controlling at high-angle-of-attack (high ...
Dongyu Zhao, Shuyuan Liu, Xinghua Chang, Laiping Zhang, Xiaogang Deng   +4 more
doaj   +1 more source

On the Epistemology of Computer Simulation

Zeitschrift für Medien- und Kulturforschung, 2011
"Der Aufsatz plädiert dafür, die Geschichte der wissenschaftlichen Computersimulation auf eine spezifisch medienhistorische Weise zu untersuchen. Nach einigen Vorschlägen zur Charakterisierung der Besonderheiten von Computersimulationen werden zwei Beispiele interpretiert (Management-Simulationen der 1960er und verkehrstechnische bzw.
openaire   +1 more source

A Computational Infrastructure for Reliable Computer Simulations [PDF]

, 2003
The reliability of computer simulations of physical events or of engineering systems has emerged as the single most critical issue facing advancements in computational engineering and science. Without concrete and quantifiable measures of reliability, the confidence and usefulness of computer predictions are severely limited and the value of computer ...
J. Tinsley Oden, James C. Browne, Ivo Babuska, Kenneth M. Liechti, Leszek F. Demkowicz   +4 more
openaire   +1 more source

MITF maintains genome stability in nonmelanocyte lineages

Molecular Oncology, EarlyView.
MITF is essential for melanocyte survival and acts as an oncogene in 10%–20% of melanomas. We show that MITF depletion causes genome instability in nonmelanocytic cells, leading to LATS2‐mediated P53 activation, cell cycle arrest, and apoptosis. This study highlights the role of MITF as a genome maintenance factor beyond the melanocyte lineage. Created
Drifa H. Gudmundsdottir, Adrián López García de Lomana, Thejus B. Venkatesh, Kritika Kirty, Snaevar Sigurdsson, Linda Vidarsdottir, Ramile Dilshat, Erla Sveinbjornsdottir, Snaedis Ragnarsdottir, Daniel H Magnusson, Maria R. Bustos, Eirikur Steingrimsson, Thorkell Gudjonsson, Stefan Sigurdsson   +13 more
wiley   +1 more source

Computer Simulations of Surfactants [PDF]

, 1993
This Chapter is a review of the computer simulations of surfactant systems. The focus is on monolayers and on micelles as relatively simple examples of surfactant self assemblies. During the last decade simulations of monolayers have progressed to a level of sophistication where they can be used to interpret experimental data and even suggest new ...
openaire   +2 more sources

A novel quinazolinone insulin receptor inhibitor and its synergy with an EGFR inhibitor in glucose‐driven glioblastoma

Molecular Oncology, EarlyView.
The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka, Wioleta Cieślik, Wojciech Płaziński, Katarzyna Stępnik, Anna Boguszewska‐Czubara, Elżbieta Kot, Robert Musioł, Mateusz Jasica, Anna Mrozek‐Wilczkiewicz, Katarzyna Malarz   +9 more
wiley   +1 more source

In vitro and in silico modelling of ROS1‐positive non‐small cell lung cancer reveals fusion‐dependent tyrosine kinase inhibitor responses

Molecular Oncology, EarlyView.
Drug resistance limits treatment success in a subset of lung cancers driven by ROS1 gene alterations. Using patient‐derived cells and computer simulations, we studied three key mutations and how they affect five targeted drugs. The mutations reduced drug effectiveness in different ways by altering protein structure and behavior.
Farhan Ul Haq, Marc Terrones, Felicia Rodrigues Fortes, Anne Schepers, Alessia Denis, Christophe Deben, Ken Op de Beeck, Guy Van Camp, Geert Vandeweyer   +8 more
wiley   +1 more source

Optimal saturated information load analysis for enhancing robustness in unmanned swarms system

Complex & Intelligent Systems
Saturated information load is defined as the information received by a unmanned aerial vehicle (UAV) node in a swarm network reaches the overload limit of its processing capability.
Jian Wu, Yichuan Jiang, Junjun Tang, Linfei Ding   +3 more
doaj   +1 more source

ZW4864‐mediated inhibition of the β‐catenin/BCL9/BCL9L complex reveals therapeutic potential in bladder cancer

Molecular Oncology, EarlyView.
BCL9 and BCL9L drive bladder cancer progression by enhancing β‐catenin signaling, promoting proliferation, migration, invasion, and organoid growth. Genetic depletion of BCL9(L) suppresses malignant phenotypes, while pharmacological disruption of the β‐catenin/BCL9(L) complex with ZW4864 inhibits canonical Wnt signaling and tumor‐associated cellular ...
Roland Kotolloshi, Mandy Berndt‐Paetz, Eileen Lerner, Gregoire Najjar, Anca Azoitei, Krishna Pal Singh, Shailendra Kumar Gupta, Olaf Wolkenhauer, Cagatay Günes, Otmar Huber, Marc‐Oliver Grimm, Daniel Steinbach   +11 more
wiley   +1 more source