Results 101 to 110 of about 6,275,059 (295)

Automated Computer Software Assessment of 5-Hydroxytryptamine 2A Receptor-Mediated Head Twitch Responses from Video Recordings of Mice. [PDF]

ACS Pharmacol Transl Sci, 2022
Glatfelter GC, Chojnacki MR, McGriff SA, Wang T, Baumann MH.   +4 more
europepmc   +1 more source

Soft motions encoded by the fold and mediated by conserved hinge sites drive V‐ATPase allosteric machinery and autoinhibition

FEBS Letters, EarlyView.
Vacuolar H+‐ATPase (V‐ATPase) is a multisubunit rotary proton pump that acidifies intracellular compartments. Using elastic network models, we identified conserved hinge residues that govern its large‐scale functional motions. We show that intrinsically encoded ‘soft modes’ drive critical functional transitions, including rotary catalysis and ...
Diksha Parwana, Xiaowei Bogetti, Stuti Sharma, Ivet Bahar   +3 more
wiley   +1 more source

DMAFL: Effective defense against malicious attacker federated learning framework via blockchain and TFHE

Journal of King Saud University: Computer and Information Sciences
A blockchain and threshold fully homomorphic encryption (TFHE)-based federated learning framework is proposed to defend against model poisoning and privacy leakage.
Chunhua Jin, Jiahao Wang, Wanru Lu, Chenfeng Luo, Junyi Liu, Guanhua Chen, Zhonghao Zhai   +6 more
doaj   +1 more source

A Kinect-Based Segmentation of Touching-Pigs for Real-Time Monitoring

Sensors, 2018
Segmenting touching-pigs in real-time is an important issue for surveillance cameras intended for the 24-h tracking of individual pigs. However, methods to do so have not yet been reported.
Miso Ju, Younchang Choi, Jihyun Seo, Jaewon Sa, Sungju Lee, Yongwha Chung, Daihee Park   +6 more
doaj   +1 more source

Validation of computer software to estimate dietary intake among patients with type 2 diabetes. [PDF]

J Clin Biochem Nutr, 2021
Wada S, Yamamoto E, Kobayashi Y, Otsuki M, Takada C, Aoi W, Okagaki M, Neriya H, Hamaguchi M, Tanaka M, Fukui M, Higashi A.   +11 more
europepmc   +1 more source

The role of miR‐335‐5p in the redifferentiation of BRAF p.V600E thyroid cancers

Molecular Oncology, EarlyView.
The BRAF p.V600E mutation promotes thyroid cancer dedifferentiation and radioiodine resistance. Using a network approach, we identified miR‐335‐5p as a key regulator of BRAF‐mutated thyroid tumors. Restoring miR‐335‐5p increased thyroid‐specific gene expression and iodine uptake in cells and organoids.
Valeria Pecce, Simone Bini, Marialuisa Sponziello, Giorgio Grani, Giulia Fiscon, Paola Paci, Lorenzo Farina, Rosa Falcone, Valentina Maggisano, Sebastiano Filetti, Cosimo Durante, Antonella Verrienti   +11 more
wiley   +1 more source

basic research in computer science and software engineering at sklcs

, 2008
The State Key Laboratory of Computer Science (SKLCS) is committed to basic research in computer science and software engineering. The research topics of the laboratory include: concurrency theory, theory and algorithms for real-time systems, formal ...
Zhang Wenhui, Wu Enhua, Zhang Jian, Zhan Naijun, Wang Yongji, Zhang Yunquan, Wang Hongan, Shen Yidong, Chen Haiming, Zhu Xueyang   +9 more
core   +1 more source

Vehicle detection in drone aerial views based on lightweight OSD-YOLOv10

Scientific Reports
To address the challenges of low performance in vehicle image detection from UAV aerial imagery, difficulties in small target feature extraction, and the large parameter size of existing models, we propose the OSD-YOLOv10 algorithm, an enhanced version ...
Yang Zhang, Xiaobing Chen, Su Sun, Hongfeng You, Yuanyuan Wang, Jianchu Lin, Jiacheng Wang   +6 more
doaj   +1 more source

Circular RNA expression landscapes in myelodysplastic neoplasms: Associations with mutational signatures and disease progression

Molecular Oncology, EarlyView.
In this explorative study, the abundance of circular RNA molecules in bone marrow stem cells was found to be elevated in patients with high‐risk myelodysplastic neoplasms, and to be associated with an increased risk of progression to acute myeloid leukemia.
Eileen Wedge, Morten Tulstrup, Gabriele Todisco, Pedro Moura, Christophe Côme, Jakob Werner Hansen, Jakob Schmidt Jespersen, Balthasar Schlotmann, Maria Creignou, Mette Dahl, Claudia Schöllkopf, Klas Raaschou‐Jensen, Krister Wennerberg, Bo Porse, Joachim Weischenfeldt, Eva Hellström‐Lindberg, Lasse Sommer Kristensen, Kirsten Grønbæk   +17 more
wiley   +1 more source

IMPDH inhibition enhances cytarabine efficacy in SAMHD1‐expressing leukaemia cells via guanine nucleotide depletion

Molecular Oncology, EarlyView.
Cytarabine is a key therapy for acute myeloid leukaemia (AML), but its efficacy is limited by the dNTPase SAMHD1, which hydrolyses its active metabolite. Screening nucleotide biosynthesis inhibitors revealed that IMPDH inhibitors selectively sensitise SAMHD1‐proficient AML cells to cytarabine.
Miriam Yagüe‐Capilla, Christopher Dirks, Caroline Eiden, Sonja K. Fesenmayer, Femke M. Hormann, Yolande Klootsema, Ingrid Lilienthal, Si Min Zhang, Nikolas Herold, Sean G. Rudd   +9 more
wiley   +1 more source