Results 81 to 90 of about 804,100 (259)

ACCOUNTING FOR COMPUTER SOFTWARE COSTS [PDF]

Analele Universităţii Constantin Brâncuşi din Târgu Jiu : Seria Economie
Hundreds of thousands of companies all over the world use computers, with different software products and other useful applications. Nowadays, businesses need these modern tools.
TEIUŞAN SORIN-CIPRIAN
doaj  

A steel defect detection method based on edge feature extraction via the Sobel operator

Scientific Reports
Scratches and cracks in steel severely affect its service life and performance. However, owing to the irregular shapes and sizes of steel surface defects, defects within the same class may be different, whereas defects between classes may be similar ...
Yuanyuan Wang, Tongtong Yin, Xiuchuan Chen, Abdullahi Suleiman Hauwa, Boyang Deng, Yemeng Zhu, Shangbing Gao, Haiyan Zang, Hu Zhao   +8 more
doaj   +1 more source

E2A selectively regulates TGF‐β–induced apoptosis in KRAS‐mutant non‐small cell lung cancer

Molecular Oncology, EarlyView.
Ability to induce apoptosis by TGF‐β is frequently lost in advanced lung adenocarcinoma despite intact TGF‐β signaling. We identify E2A as a mutant KRAS–dependent mediator of resistance to TGF‐β–induced apoptosis. TGF‐β induces E2A via SMAD3 in mutant KRAS cells, and E2A silencing restores apoptosis and enhances radiation response in cell lines ...
Sergei Chuikov, Shiva Krishna Katkam, Zhefan Wang, Venkateshwar G. Keshamouni   +3 more
wiley   +1 more source

A novel image encryption scheme using 3D chaotic maps with Josephus permutation and dynamic diffusion

Journal of King Saud University: Computer and Information Sciences
With the rapid development of digital communication, cloud computing, and intelligent applications such as smart healthcare and the Internet of Things (IoT), secure image transmission has become a critical challenge.
Wanru Lu, Chunhua Jin, Jiahao Wang, Xinying Liu, Junyi Liu, Zhonghao Zhai   +5 more
doaj   +1 more source

CD47 promotes mitogen‐activated protein kinase and epithelial‐to‐mesenchymal transition molecular programs to drive prometastatic phenotypes in non‐small cell lung cancer

Molecular Oncology, EarlyView.
Beyond its role in immune evasion, this study identified that CD47 drives tumor‐intrinsic signaling in non‐small cell lung cancer (NSCLC). Transcriptomic profiling and functional studies revealed that CD47 regulates cell adhesion, migration, and metastasis through an ERK–EMT signaling axis.
Asa P.Y. Lau, Lilian G. Zhai, Ryunosuke Hoshi, Zackary Rousseau, Abraam Zakhary, Yin Fang Wu, Rola M. Saleeb, Heyu Ni, Kelsie L. Thu   +8 more
wiley   +1 more source

Node classification in complex networks based on multi-view debiased contrastive learning

Complex & Intelligent Systems
In complex networks, contrastive learning has emerged as a crucial technique for acquiring discriminative representations from graph data. Maximizing the similarity among relevant sample pairs while minimizing that among irrelevant pairs is pivotal in ...
Zhe Li, Lei Zhou, Yandong Hou, Min Ji, Zhuanzheng Hang, Bolun Chen   +5 more
doaj   +1 more source

KDM7A and KDM1A inhibition suppresses tumour promoting pathways in prostate cancer

Molecular Oncology, EarlyView.
Treatment resistance is a major challenge for patients with advanced prostate cancer. This study examined an alternative approach to target the major prostate cancer‐promoting pathway by targeting epigenetic factors, whose levels are higher in tumours.
Jennie N Jeyapalan, Veronika M Metzler, Simone de Brot, Corinne L Woodcock, Anna E Harris, Jennifer Lothion‐Roy, Emeli M Nilsson, Atara Ntekim, Michael S Toss, Jenny L Persson, Francesca Khani, Brian D Robinson, Lorraine J Gudas, Emad Rakha, David M Heery, Catrin S Rutland, Nigel P Mongan   +16 more
wiley   +1 more source

Heterozygous loss‐of‐function alleles associate the conserved 3′‐5′ exoribonuclease EXOSC10 with hypersensitivity to the anticancer drug 5‐fluorouracil

Molecular Oncology, EarlyView.
EXOSC10, an essential nuclear RNA exosome‐associated 3′‐5′ exoribonuclease, is inhibited by the anticancer drug 5‐fluorouracil (5‐FU), and EXOSC10 depletion increases 5‐FU sensitivity. The colon‐cancer variant EXOSC10S402T, located in a proteolysis motif, is stable and nuclear but nonfunctional in vivo.
Radhika Sain, Yann Le Page, Frédéric Percevault, Emmanuelle Becker, Luc Negroni, Almudena Fernandez, Marta Cantero, Diego Muñoz‐Santos, Lluís Montoliu, Cyrille Garnier, Michael Primig   +10 more
wiley   +1 more source

Analyzing the 2021 Kaseya Ransomware Attack: Combined Spearphishing Through SonicWall SSLVPN Vulnerability

IET Information Security
In July 2021, the IT management software company Kaseya was the victim of a ransomware cyberattack. The perpetrator of this attack was ransomware evil (REvil), an allegedly Russian-based ransomware threat group. This paper addresses the general events of
Suman Bhunia, Matthew Blackert, Henry Deal, Andrew DePero, Amar Patra   +4 more
doaj   +1 more source

Cell‐cycle‐specific lesion evolution rather than inhibition of double‐strand‐break repair underpins cisplatin radiosensitization

Molecular Oncology, EarlyView.
We analyze cisplatin–DNA adducts (CDAs) and double‐strand breaks (DSBs) in a cell‐cycle‐dependent manner. We find that CDAs form similarly across all cell cycle phases. DSBs arise only in S‐phase. CDAs might not directly impair DSB repair, but S‐phase DSB lesions evolve in the presence of CDAs and disrupt repair in G2, also causing radiosensitization ...
Ye Qiu, Xixi Lin, Emil Mladenov, Veronika Mladenova, Jürgen Thomale, Ali Sak, Yao Wang, Yunxuan Deng, Eleni Gkika, Martin Stuschke, George Iliakis   +10 more
wiley   +1 more source