Results 61 to 70 of about 3,380,527 (288)

The neural crest‐associated gene ERRFI1 is involved in melanoma progression and resistance toward targeted therapy

open access: yesMolecular Oncology, EarlyView.
ERRFI1, a neural crest (NC)‐associated gene, was upregulated in melanoma and negatively correlated with the expression of melanocytic differentiation markers and the susceptibility of melanoma cells toward BRAF inhibitors (BRAFi). Knocking down ERRFI1 significantly increased the sensitivity of melanoma cells to BRAFi.
Nina Wang   +8 more
wiley   +1 more source

Brief Mood Introspection Scale (BMIS): Open-Source Code [PDF]

open access: yes, 1988
This is computer code for analyzing the Brief Mood Introspection Scale (BMIS) data files for the R Statistical Environment open source ...
Mayer, John D.
core   +2 more sources

In vitro models of cancer‐associated fibroblast heterogeneity uncover subtype‐specific effects of CRISPR perturbations

open access: yesMolecular Oncology, EarlyView.
Development of therapies targeting cancer‐associated fibroblasts (CAFs) necessitates preclinical model systems that faithfully represent CAF–tumor biology. We established an in vitro coculture system of patient‐derived pancreatic CAFs and tumor cell lines and demonstrated its recapitulation of primary CAF–tumor biology with single‐cell transcriptomics ...
Elysia Saputra   +10 more
wiley   +1 more source

How to Use the Web Soil Survey to Find Information about Your Land

open access: yesEDIS
The purpose of this publication is to provide step-by-step guidance on how to find soil data about a given parcel of land in the Web Soil Survey. This publication can be used by residents, growers, gardeners, construction personnel, landscape managers ...
Mary G. Lusk
doaj   +1 more source

Exploiting metabolic adaptations to overcome dabrafenib treatment resistance in melanoma cells

open access: yesMolecular Oncology, EarlyView.
We show that dabrafenib‐resistant melanoma cells undergo mitochondrial remodeling, leading to elevated respiration and ROS production balanced by stronger antioxidant defenses. This altered redox state promotes survival despite mitochondrial damage but renders resistant cells highly vulnerable to ROS‐inducing compounds such as PEITC, highlighting redox
Silvia Eller   +17 more
wiley   +1 more source

UF/IFAS Florida Trees Tutorial

open access: yesEDIS
The UF/IFAS Florida Trees website contains a database of detailed information on over 1000 trees. The website's Tree Recommendation Tool presented in this publication can help the user do a thorough site analysis, identify important characteristics of ...
Ryan W. Klein   +2 more
doaj   +1 more source

Cell surface interactome analysis identifies TSPAN4 as a negative regulator of PD‐L1 in melanoma

open access: yesMolecular Oncology, EarlyView.
Using cell surface proximity biotinylation, we identified tetraspanin TSPAN4 within the PD‐L1 interactome of melanoma cells. TSPAN4 negatively regulates PD‐L1 expression and lateral mobility by limiting its interaction with CMTM6 and promoting PD‐L1 degradation.
Guus A. Franken   +7 more
wiley   +1 more source

A regional land use survey based on remote sensing and other data: A report on a LANDSAT and computer mapping project, volume 2 [PDF]

open access: yes
The author has identified the following significant results. The project mapped land use/cover classifications from LANDSAT computer compatible tape data and combined those results with other multisource data via computer mapping/compositing techniques ...
Mutter, D., Nez, G.
core   +1 more source

State machines for large scale computer software and systems

open access: yes, 2020
A method for specifying the behavior and architecture of discrete state systems such as digital electronic devices and software using deterministic state machines and automata products.
Yodaiken, Victor
core  

PARP inhibition and pharmacological ascorbate demonstrate synergy in castration‐resistant prostate cancer

open access: yesMolecular Oncology, EarlyView.
Pharmacologic ascorbate (vitamin C) increases ROS, disrupts cellular metabolism, and induces DNA damage in CRPC cells. These effects sensitize tumors to PARP inhibition, producing synergistic growth suppression with olaparib in vitro and significantly delayed tumor progression in vivo. Pyruvate rescue confirms ROS‐dependent activity.
Nicolas Gordon   +13 more
wiley   +1 more source

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