Results 51 to 60 of about 3,360,768 (285)
Introduction: Cognitive rehabilitation has an effect on the improvement of symptoms of dyscalculia disorder such as executive function and quantitative reasoning and affects other children's functions.
Monir Rostamabadi +2 more
doaj +1 more source
In this study, we present the structure of AcrIE8.1, a previously uncharacterized anti‐CRISPR protein that inhibits the type I‐E CRISPR‐Cas system. Through a combination of structural and biochemical analyses, we demonstrate that AcrIE8.1 directly binds to the Cas11 subunit of the Cascade complex to inhibit the CRISPR‐Cas system.
Young Woo Kang, Hyun Ho Park
wiley +1 more source
Justification of the costs of forest reclamation of lands subject to desertification
Background. In recent decades, environmental problems related to land degradation and depletion of soil cover have become especially acute in the south of Russia. The consequences of these threats are commonly referred to as desertification.
Evgenia A. Korneeva
doaj +1 more source
Computer-aided veterinary learning at the University of Cambridge [PDF]
An approach to computer-assisted learning in veterinary education at the University of Cambridge, involving the development of four types of learning module, is outlined.
Holmes, M.A., Nicholls, P.K.
core +2 more sources
A Cre‐dependent lentiviral vector for neuron subtype‐specific expression of large proteins
We designed a versatile and modular lentivector comprising a Cre‐dependent switch and self‐cleaving 2A peptide and tested it for co‐expression of GFP and a 2.8 kb gene of interest (GOI) in mouse cortical parvalbumin (PV+) interneurons and midbrain dopamine (TH+) neurons.
Weixuan Xue +6 more
wiley +1 more source
Stability of a compressed-tensioned rod of variable cross-section with combined loading
Objective. The purpose of the study is to determine the stability of a straight rod of variable cross-section under combined axial loading. Method. The longitudinal bending of the rod is described by the classical theory using Bernoulli’s hypothesis, and
H. P. Kulterbaev, M. M. Payzulaev
doaj +1 more source
Anaplastic thyroid cancer (ATC) lacks iodide uptake ability due to MAPK activation increasing the expression of the histone methyltransferase EZH2, which represses thyroid differentiation genes (TDGs) such as the sodium iodide symporter (NIS). Dual inhibition of MAPK (U0126) and EZH2 (EPZ6438/Tazemetostat) reverses this mechanism, thus restoring TDG ...
Diego Claro de Mello +6 more
wiley +1 more source
Phosphatidylinositol 4‐kinase as a target of pathogens—friend or foe?
This graphical summary illustrates the roles of phosphatidylinositol 4‐kinases (PI4Ks). PI4Ks regulate key cellular processes and can be hijacked by pathogens, such as viruses, bacteria and parasites, to support their intracellular replication. Their dual role as essential host enzymes and pathogen cofactors makes them promising drug targets.
Ana C. Mendes +3 more
wiley +1 more source
Software for Wearable Devices: Challenges and Opportunities
Wearable devices are a new form of mobile computer system that provides exclusive and user-personalized services. Wearable devices bring new issues and challenges to computer science and technology.
Chen, Xin +5 more
core +1 more source
Bifidobacterium bifidum establishes symbiosis with infants by metabolizing lacto‐N‐biose I (LNB) from human milk oligosaccharides (HMOs). The extracellular multidomain enzyme LnbB drives this process, releasing LNB via its catalytic glycoside hydrolase family 20 (GH20) lacto‐N‐biosidase domain.
Xinzhe Zhang +5 more
wiley +1 more source

